Acta Pharmaceutica Sinica B,
Journal Year:
2020,
Volume and Issue:
11(4), P. 941 - 960
Published: Dec. 31, 2020
The
initiation
and
development
of
major
inflammatory
diseases,
i.e.,
cancer,
vascular
inflammation,
some
autoimmune
diseases
are
closely
linked
to
the
immune
system.
Biologics-based
immunotherapy
is
exerting
a
critical
role
against
these
whereas
usage
immunomodulators
always
limited
by
various
factors
such
as
susceptibility
digestion
enzymes
in
vivo,
poor
penetration
across
biological
barriers,
rapid
clearance
reticuloendothelial
Drug
delivery
strategies
potent
promote
their
delivery.
Herein,
we
reviewed
potential
targets
for
discussed
biologics
drug
systems
involved
immunotherapy,
particularly
highlighted
approved
therapy
tactics,
finally
offer
perspectives
this
field.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(5), P. 627 - 627
Published: April 24, 2022
The
vastness
of
metal-based
nanoparticles
has
continued
to
arouse
much
research
interest,
which
led
the
extensive
search
and
discovery
new
materials
with
varying
compositions,
synthetic
methods,
applications.
Depending
on
applications,
many
methods
have
been
used
prepare
these
materials,
found
applications
in
different
areas,
including
biology.
However,
prominent
nature
associated
toxicity
environmental
concerns
involved
most
conventional
limited
their
continuous
usage
due
desire
for
more
clean,
reliable,
eco-friendly,
biologically
appropriate
approaches.
Plant-mediated
approaches
metal
emerged
circumvent
often-associated
disadvantages
routes,
using
bioresources
that
act
as
a
scaffold
by
effectively
reducing
stabilizing
whilst
making
them
biocompatible
biological
cells.
This
capacity
plants
intrinsically
utilize
organic
processes
reorganize
inorganic
ions
into
thus
studies
this
area
biochemical
synthesis
analysis.
In
review,
we
examined
use
several
plant
extracts
mediating
agent
(MNPs).
Furthermore,
properties,
suggested
emanate
from
influence
diverse
metabolites
plants,
were
also
reviewed.
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
11(10), P. 3060 - 3091
Published: May 7, 2021
Acute
respiratory
distress
syndrome
(ARDS)
is
characterized
by
the
severe
inflammation
and
destruction
of
lung
air-blood
barrier,
leading
to
irreversible
substantial
function
damage.
Patients
with
coronavirus
disease
2019
(COVID-19)
have
been
encountered
a
high
risk
ARDS,
underscoring
urgency
for
exploiting
effective
therapy.
However,
proper
medications
ARDS
are
still
lacking
due
poor
pharmacokinetics,
non-specific
side
effects,
inability
surmount
pulmonary
inadequate
management
heterogeneity.
The
increased
permeability
in
pathological
environment
may
contribute
nanoparticle-mediated
passive
targeting
delivery.
Nanomedicine
has
demonstrated
unique
advantages
solving
dilemma
drug
therapy,
which
can
address
shortcomings
limitations
traditional
anti-inflammatory
or
antioxidant
treatment.
Through
passive,
active,
physicochemical
targeting,
nanocarriers
interact
epithelium/endothelium
inflammatory
cells
reverse
abnormal
changes
restore
homeostasis
environment,
thereby
showing
good
therapeutic
activity
reduced
toxicity.
This
article
reviews
latest
applications
nanomedicine
pre-clinical
highlights
strategies
targeted
treatment
inflammation,
presents
innovative
delivery
systems,
provides
inspiration
strengthening
effect
nanomedicine-based
ACS Biomaterials Science & Engineering,
Journal Year:
2022,
Volume and Issue:
8(5), P. 1763 - 1790
Published: April 19, 2022
Dexamethasone
(DEX)
has
been
widely
used
to
treat
a
variety
of
diseases,
including
autoimmune
allergies,
ocular
disorders,
cancer,
and,
more
recently,
COVID-19.
However,
DEX
usage
is
often
restricted
in
the
clinic
due
its
poor
water
solubility.
When
administered
through
systemic
route,
it
can
elicit
severe
side
effects,
such
as
hypertension,
peptic
ulcers,
hyperglycemia,
and
hydro-electrolytic
disorders.
There
currently
much
interest
developing
efficient
DEX-loaded
nanoformulations
that
ameliorate
adverse
disease
effects
inhibiting
advancements
scientific
research.
Various
nanoparticles
have
developed
selectively
deliver
drugs
without
destroying
healthy
cells
or
organs
recent
years.
In
present
review,
we
summarized
some
most
attractive
applications
delivery
systems,
liposomes,
polymers,
hydrogels,
nanofibers,
silica,
calcium
phosphate,
hydroxyapatite.
This
review
provides
our
readers
with
broad
spectrum
nanomedicine
approaches
safely.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 488 - 488
Published: April 19, 2024
Plants
have
proven
to
be
important
sources
for
discovering
new
compounds
that
are
useful
in
the
treatment
of
various
diseases
due
their
phytoconstituents.
Clove
(
BioChem,
Journal Year:
2024,
Volume and Issue:
4(1), P. 38 - 61
Published: March 13, 2024
Arthritis,
a
global
health
burden
comprising
osteoarthritis
and
rheumatoid
arthritis,
demands
advanced
therapeutic
approaches.
In
this
context,
flavonoids,
diverse
group
of
naturally
occurring
compounds
abundant
in
fruits,
vegetables,
medicinal
plants,
have
emerged
as
promising
candidates
for
mitigating
the
inflammatory
processes
associated
with
arthritic
conditions.
This
review
aims,
first,
to
provide
comprehensive
exploration
potential
focusing
on
specific
such
quercetin,
epigallocatechin-3-gallate
(EGCG),
apigenin,
luteolin,
fisetin,
silibinin,
kaempferol,
naringenin,
myricetin.
The
second
section
delves
into
anti-arthritic
activities
these
drawing
insights
from
clinical
trials
scientific
studies.
Each
flavonoid
is
scrutinized
individually
elucidate
its
mechanisms
action
efficacy
context
both
arthritis.
third
highlights
challenges
harnessing
flavonoids
anti-inflammatory
purposes.
Bioavailability
limitations
pose
significant
hurdle,
prompting
innovative
strategies
use
nanoparticles
delivery
vehicles.
response
challenges,
fourth
focuses
emerging
field
flavonoid-based
nanoparticles.
includes
detailed
discussions
EGCG,
naringenin-based
nanoparticles,
highlighting
formulation
preclinical
evidence
supporting
their
arthritis
management.
targeted
sites
synergistic
combinations
other
are
also
discussed
avenues
enhance
impact
flavonoids.
consolidates
current
knowledge
nanoformulations
interventions
By
addressing
presenting
future
research
directions,
aims
contribute
advancement
effective
alleviating
