Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Recent Progress of Rare‐Earth Doped Upconversion Nanoparticles: Synthesis, Optimization, and Applications

Advanced Science, Journal Year: 2019, Volume and Issue: 6(22)

Published: Sept. 30, 2019

Abstract Upconversion is a nonlinear optical phenomenon that involves the emission of high‐energy photons by sequential absorption two or more low‐energy excitation photons. Due to their excellent physiochemical properties such as deep penetration depth, little damage samples, and high chemical stability, upconversion nanoparticles (UCNPs) are extensively applied in bioimaging, biosensing, theranostic, photochemical reactions. Here, recent achievements synthesis, optimization, applications UCNP‐based nanomaterials reviewed. The state‐of‐the‐art approaches synthesize UCNPs past few years introduced first, followed summary several strategies optimize emissive various UCNPs. Lastly, challenges future perspectives provided conclusion.

Language: Английский

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Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

Advanced Science, Journal Year: 2018, Volume and Issue: 5(3)

Published: Jan. 9, 2018

Significant progress on upconversion-nanoparticle (UCNP)-based probes is witnessed in recent years. Compared with traditional fluorescent (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non-autofluorescence, high chemical stability, large light-penetration depth, long lifetime, and less damage to samples. This article focuses achievements the usage of lanthanide-doped efficient for biodetection since 2014. The mechanisms upconversion well luminescence resonance energy transfer process introduced first, followed by a detailed summary researches UCNP-based biodetections including detection ions, gas molecules, reactive oxygen species, thiols hydrogen sulfide.

Language: Английский

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Catalytic Nanomaterials toward Atomic Levels for Biomedical Applications: From Metal Clusters to Single-Atom Catalysts

ACS Nano, Journal Year: 2021, Volume and Issue: 15(2), P. 2005 - 2037

Published: Feb. 10, 2021

Single-atom catalysts (SACs) featuring the complete atomic utilization of metal, high-efficient catalytic activity, superior selectivity, and excellent stability have been emerged as a frontier in field. Recently, increasing interests drawn to apply SACs biomedical fields for enzyme-mimic catalysis disease therapy. To fulfill demand precision personalized medicine, precisely engineering structure active site toward levels is trend nanomedicines, promoting evolution metal-based nanomaterials, particularly biocatalytic from nanoparticles clusters now SACs. This review outlines syntheses, characterizations, mechanisms metal SACs, with focus on their applications including biosensing, antibacterial therapy, cancer well an emphasis vivo biological safeties. Challenges future perspectives are ultimately prospected diverse applications.

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Recent advances in nanotechnology for simultaneous detection of multiple pathogenic bacteria

Nano Today, Journal Year: 2021, Volume and Issue: 38, P. 101121 - 101121

Published: March 11, 2021

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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Nanochemistry advancing photon conversion in rare-earth nanostructures for theranostics

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 460, P. 214486 - 214486

Published: March 9, 2022

Language: Английский

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Recent progress of rare earth doped hydroxyapatite nanoparticles: Luminescence properties, synthesis and biomedical applications

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 148, P. 22 - 43

Published: June 5, 2022

Language: Английский

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Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(2), P. 2499 - 2528

Published: Jan. 5, 2023

Lanthanide-doped upconversion nanoparticles (UCNPs) possess the remarkable ability to convert multiple near-infrared (NIR) photons into higher energy ultraviolet-visible (UV-vis) photons, making them a prime candidate for several advanced applications within realm of nanotechnology. Compared traditional organic fluorophores and quantum dots (QDs), UCNPs narrower emission bands (fwhm 10-50 nm), large anti-Stokes shifts, low toxicity, high chemical stability, resistance photobleaching blinking. In addition, unlike UV-vis excitation, NIR excitation is nondestructive at lower power intensities has tissue penetration depths (up 2 mm) with autofluorescence scattering. Together, these properties make exceedingly favored bioanalytical theranostic applications, where systems have been well-explored. are also well-suited bioimaging, optically modulating chemistries, forensic science, other state-of-the-art research applications. this review, an up-to-date account emerging in UCNP research, beyond theranostics, presented including optogenetics, super-resolution imaging, encoded barcodes, fingerprinting, vision, UCNP-assisted photochemical manipulations, optical tweezers, 3D printing, lasing, NIR-II UCNP-molecule nanohybrids, UCNP-based persistent luminescent nanocrystals.

Language: Английский

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