Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: Aug. 2, 2021

Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long time and photosensitizers (PS) can be in various types of tumors. Originally, light is effective tool that the diseases ages. The effects combination specific dyes with illumination was demonstrated at beginning 20th century novel PDT approaches have developed ever since. Main strategies current studies are to reduce off-target improve pharmacokinetic properties. Given high interest vast literature about topic, approval first drug/device by FDA should come no surprise. consists two stages treatment, combining energy PS order destruct tumor cells after activation light. In general, fewer side toxicity than chemotherapy and/or radiotherapy. addition purpose several PSs diagnostic purposes Such called photodynamic diagnosis (PDD). this Review, we provide general overview clinical applications cancer, including therapeutic approaches. Assessment efficacy clinic will discussed, since identifying predictors determine response crucial. addition, examples tumors discussed. Furthermore, other modalities such chemotherapy, radiotherapy, surgery immunotherapy emphasized, seem promising terms enhancing effectiveness against tumor. treatments may yield better results single treatments. Moreover, utilization lower doses setting cause less therapy. A understanding well optimization complex multimodal expand PDT.

Language: Английский

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Photodynamic Therapy: A Compendium of Latest Reviews

Cancers, Journal Year: 2021, Volume and Issue: 13(17), P. 4447 - 4447

Published: Sept. 3, 2021

Photodynamic therapy (PDT) is a promising against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present brief compendium of reviews decades classified under different topics, namely, overviews, about specific cancers, and meta-analyses photosensitisers, PDT mechanisms, dosimetry, light sources. The key issues main conclusions are summarized, including ways means to improve outcomes. Due broad scope work being first time that latest performed PDT, may be interest wide audience.

Language: Английский

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Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Advanced Science, Journal Year: 2021, Volume and Issue: 9(5)

Published: Dec. 19, 2021

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates dose-limiting toxicity remain as major dilemmas immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with offer possibility amplify anti-tumor immune responses, where weak acidity, high concentration of glutathione, overexpressions enzymes, reactive oxygen species, external stimuli in act triggers controlled drug release. This review highlights design srNPs based on tumor microenvironment and/or combine different drugs, especially immunoregulatory agents, which eventually realize synergistic malignant primary or acquire a long-term memory prevent recurrence. The authors hope that this can provide theoretical guidance construction transformation smart delivery cancer

Language: Английский

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Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Biomaterials, Journal Year: 2022, Volume and Issue: 282, P. 121433 - 121433

Published: Feb. 19, 2022

Language: Английский

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Which cell death modality wins the contest for photodynamic therapy of cancer?

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(5)

Published: May 13, 2022

Abstract Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed the treatment of several types cancer. Traditionally, cell death induced by categorized into three types: apoptosis, associated with autophagy, necrosis. However, discovery other regulated modalities in recent years, it has become clear that this is a rather simple understanding mechanisms action PDT. New observations revealed cancer cells exposed to can pass through various non-conventional pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, ferroptosis. Nowadays, immunogenic (ICD) one most promising ways eradicate tumor activation T-cell adaptive immune response induction long-term immunological memory. ICD be triggered anti-cancer methods, including In review, we critically discuss findings on Next, emphasize role contribution these PDT-induced modalities. Finally, obstacles propose areas research will help overcome challenges lead development highly effective based

Language: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(18)

Published: Nov. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Language: Английский

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Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Cancers, Journal Year: 2021, Volume and Issue: 13(14), P. 3484 - 3484

Published: July 13, 2021

Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some the main beneficial features PDT. Despite great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, complicated implementations clinic limiting factors hindering extended use To surpass actual technological paradigms, radically new sources, light-based devices, advanced measurement innovative strategies under extensive investigation. The aim this review to highlight advantages/pitfalls, technical challenges opportunities PDT, focus on technologies for activation such as delivery systems. In vein, broad overview current status superficial, interstitial, deep PDT modalities-and critical sources their effects process-are presented. Insight into advancements remaining optical devices provided from physical bioengineering perspective.

Language: Английский

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A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 299 - 312

Published: Sept. 13, 2022

To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction immunogenic cell death (ICD) at tumor sites can increase antigenicity and adjuvanticity to activate microenvironment so that tumors become sensitive intervention inhibitors. Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation epirubicin (EPI), glucose oxidase (Gox) hemin ZIF-8 nanoparticles coating with calreticulin (CRT) over-expressed membrane. EPI acts an ICD inducer, Gox medicate cascade generation reactive oxygen species (ROS) strengthen effect, CRT-rich membrane "eat me" signal promote presentation released antigens dendritic cells (DCs) invoke tumor-immunity cycle. The delivery system displays amplified effect via oxidation, hydroxyl radical glutathione (GSH) depletion. induced potent promotes DCs maturation cytotoxic T lymphocytes (CTLs) infiltration, reversing immunoresponsive one. Treatment nanosystem combination results distinctive inhibition growth lung metastasis, supporting significantly boost therapeutic efficacy antibody. This nanoplatform offers promising means raising

Language: Английский

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Functional states of myeloid cells in cancer

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 490 - 504

Published: March 1, 2023

Language: Английский

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