Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy DOI
Xiaoyu Xu, Meixu Chen, Shan Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Language: Английский

Sonodynamic therapy: Rapid progress and new opportunities for non-invasive tumor cell killing with sound DOI Creative Commons
Katherine M. Nowak,

Mark R. Schwartz,

Victoria R. Breza

et al.

Cancer Letters, Journal Year: 2022, Volume and Issue: 532, P. 215592 - 215592

Published: Feb. 11, 2022

Language: Английский

Citations

85
Stimuli responsive nanosonosensitizers for sonodynamic therapy DOI

Zeyu Jiang,

Wen‐Jing Xiao, Qinrui Fu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

Citations

77
Rational Design of Platinum–Bismuth Sulfide Schottky Heterostructure for Sonocatalysis‐Mediated Hydrogen Therapy DOI
Meng Yuan, Shuang Liang, Ling Yang

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(10)

Published: Dec. 18, 2022

Conventional sonodynamic therapy is unavoidably limited by the tumor microenvironment, although many sonosensitizers have been developed to improve them a certain extent. Given this, concept of sonocatalytic hydrogen evolution proposed, which defined as an oxygen-independent therapeutics. To demonstrate feasibility concept, narrow-bandgap semiconductor bismuth sulfide (Bi2 S3 ) selected sonocatalyst and platinum (Pt) nanoparticles are grown in situ optimize their catalytic performance. In this nanocatalytic system, Pt help capture sonoexcited electrons, whereas intratumoral overexpressed glutathione (GSH), natural hole sacrificial agent, can consume holes, greatly improves charge-separation efficiency promotes controllable sustainable H2 generation. Even under hypoxic conditions, Pt-Bi2 also produce sufficient ultrasound irradiation. Mechanistically, mitochondrial dysfunction caused redox homeostasis destruction GSH depletion synergistically damage DNA induce cells apoptosis. At same time, holes trigger decomposition peroxide into O2 relieve hypoxia, thus being synergistic with reverse immunosuppressive microenvironment. The proposed sonocatalysis-mediated will provide new direction realize facile efficient cancer therapy.

Language: Английский

Citations

76
State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT DOI

Zuoxiu Xiao,

Qiaohui Chen, Yuqi Yang

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 449, P. 137889 - 137889

Published: July 4, 2022

Language: Английский

Citations

74
Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy DOI
Shipeng Ning, Xingliang Dai,

Weiwei Tang

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 152, P. 562 - 574

Published: Sept. 5, 2022

Language: Английский

Citations

73
Mechano‐Responsive Leapfrog Micelles Enable Interactive Apoptotic and Ferroptotic Cancer Therapy DOI
Yao Li, Yan Qin,

Yaqi Shang

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(29)

Published: April 28, 2022

Abstract The combination of apoptosis and ferroptosis is highly appealing in addressing the tumor heterogeneity‐induced therapy resistance. Reactive oxygen species (ROS)‐based cancer nanomedicine can assemble multiple cell death modalities a single platform, but potency induction limited. Here, novel mechano‐responsive polymeric micellar system for selective boosting ROS sensitization reported. mechanophore, ferrocene (Fc) key to such design, ultrasound speed up dissociation Fc release Fe 2+ hydroxyl radical presence elevated H 2 O microenvironment. Fc‐conjugated amphiphilic copolymers self‐assemble into nanoscale micelles wherein model sonosensitizer, protoporphyrin IX physically encapsulated. Upon triggering, produce both singlet apoptotic murine breast line (4T1). also depletes intracellular glutathione thioredoxin, which together with heightened level boosts lipid peroxidation hence ferroptotic death. interactive further demonstrated 4T1 tumor‐bearing mice negligible adverse effects. current work provides approach simultaneously sensitize efficient on‐demand therapy.

Language: Английский

Citations

72
GSH‐Activated Porphyrin Sonosensitizer Prodrug for Fluorescence Imaging‐Guided Cancer Sonodynamic Therapy DOI

Caiting Deng,

Meichen Zheng,

Shupeng Han

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(32)

Published: May 5, 2023

Sonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer generate reactive oxygen species (ROS), is promising form of cancer with outstanding tissue penetration depth. However, the may inevitably spread surrounding healthy beyond tumor, resulting in undesired side effects under an stimulus. Herein, as glutathione (GSH) overexpressed tumor microenvironment, GSH-activatable prodrug was designed by attaching quencher tetraphydroxy porphyrin for therapy. The exhibited poor fluorescence and low ROS generation capacity irradiation but it can be activated GSH simultaneously switch on emission site. Compared non-quenched sonosensitizer, significantly higher tumor/healthy organ ratios, due specific activation tumor. Finally, efficient growth inhibition irradiation, further demonstrating its promise GSH-activated highly effective treatment.

Language: Английский

Citations

55
Recent Advances of Platinum‐Based Anticancer Complexes in Combinational Multimodal Therapy DOI Open Access

Tianyuan Zhong,

Jie Yu, Yong Pan

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: April 25, 2023

Abstract Platinum drugs with manifest therapeutic effects are widely used, but their systemic toxicity and the drug resistance acquired by cancer cells limit clinical applications. Thus, exploration on appropriate methods strategies to overcome limitations of traditional platinum becomes extremely necessary. Combination therapy can inhibit tumor growth metastasis in an additive or synergistic manner, potentially reduce platinum‐resistance. This review summarizes various modalities current progress platinum‐based combination therapy. The synthetic some anticancer complexes gene editing, ROS‐based therapy, thermal immunotherapy, biological modelling, photoactivation, supramolecular self‐assembly imaging modality briefly described. Their potential challenges prospects also discussed. It is hoped that this will inspire researchers have more ideas for future development highly effective anti‐cancer complexes.

Language: Английский

Citations

44
Current advances in metal–organic frameworks for cancer nanodynamic therapies DOI

Zhu Liu,

Ziwei Yan,

Yifan Di

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

Citations

43
A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy DOI Creative Commons
Xu Chen, Bárbara B. Mendes, Yunhui Zhuang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(2), P. 1644 - 1656

Published: Jan. 4, 2024

Photodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen supply. However, therapeutic efficacy PSs greatly compromised by poor solubility, aggregation tendency, depletion within solid tumors during PDT in hypoxic microenvironments. Despite potential PS-based metal–organic frameworks (MOFs), addressing hypoxia remains challenging. Boron dipyrromethene (BODIPY) chromophores, with excellent photostability, have exhibited great bioimaging. their practical application suffers from limited chemical stability under harsh MOF synthesis conditions. Herein, we report first example Zr-based MOF, namely, 69-L2, exclusively constructed BODIPY-derived ligands via single-crystal to post-synthetic exchange, where direct solvothermal method not applicable. To increase performance hypoxia, modify 69-L2 fluorinated phosphate-functionalized methoxy poly(ethylene glycol). The resulting 69-L2@F carrier, enabling tumor oxygenation simultaneously acting as PS for reactive species (ROS) generation LED irradiation. We demonstrate that has enhanced effect triple-negative breast MDA-MB-231 cells both normoxia hypoxia. Following positive results, evaluated vivo activity hydrogel, local mice model achieving exceptional antitumor only 2 days. envision BODIPY-based Zr-MOFs provide solution relief maximize PDT, offering new insights into design promising MOF-based tumors.

Language: Английский

Citations

42