Biodegradable CuMoO4 Nanodots with Multienzyme Activities for Multimodal Treatment of Tumor DOI

Jinzha Zhang,

Liqi Peng,

Yijie Hao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: May 24, 2023

Due to their complexity and variability, tumors need be treated with multimodal combined therapy, which requires the development of therapeutic agents that can provide effects. Herein, CuMoO4 nanodots smaller than 10 nm prepared by simple hydrothermal method are reported. These well dispersed in water have good biosafety biodegradability. Further studies show these also present multienzyme activities, such as catalase, peroxidase glutathione peroxidase. In addition, exhibit high photothermal conversion efficiency (41%) under 1064 near-infrared laser irradiation. vitro vivo experimental results indicate effectively inhibit instinctive regulation tumor cells oxidative stress, sustained treatment achieve synergistic ferroptosis, trigger immune responses immunogenic cell death. It is worth mentioning cause cuproptosis cells. This study provides a promising nanoplatform for therapy cancer.

Language: Английский

Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy DOI Creative Commons
Weiwei Zeng, Mian Yu, Ting Chen

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(23)

Published: June 9, 2022

Nanozyme-based tumor catalytic therapy has attracted widespread attention in recent years, but its therapeutic outcome is drastically diminished by species of nanozyme, concentration substrate, pH value, and reaction temperature, etc. Herein, a novel Cu-doped polypyrrole nanozyme (CuP) with trienzyme-like activities, including catalase (CAT), glutathione peroxidase (GPx), (POD), first proposed straightforward one-step procedure, which can specifically promote O

Language: Английский

Citations

119
Multi-enzyme activity nanozymes for biosensing and disease treatment DOI
Su Li,

Sainan Qin,

Zhongjian Xie

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214784 - 214784

Published: Sept. 13, 2022

Language: Английский

Citations

95
Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy DOI
Yujie Zhu, Quguang Li, Chunjie Wang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 7326 - 7378

Published: March 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Language: Английский

Citations

94
Vaccine-like nanomedicine for cancer immunotherapy DOI
Yunfei Yi, Mian Yu, Wen Li

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 760 - 778

Published: Feb. 24, 2023

Language: Английский

Citations

88
Biodegradable NIR‐II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor‐Associated Macrophage Reprogramming DOI

Jia Wan,

Xianghong Zhang, Dongsheng Tang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(31)

Published: June 7, 2023

Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its promise, the efficacy of photodynamic immunotherapy can be limited by hypoxia solid tumors which is closely related to abnormal tumor vasculature. These vasculatures are a hallmark most and facilitate immune evasion. Therefore, vascular normalization developed as promising strategy overcome hypoxia, resulting improved therapy. Here, NIR-II bio-degradable pseudo-conjugate polymer (PSP)-based designed deliver agent, i.e., regorafenib (Reg) nanoparticles (NP-PDT@Reg). NP-PDT@Reg under 808 nm laser irradiation (NP-PDT@Reg + L) efficiently release Reg improve via normalization, making more oxygen enter tumors. Moreover, L further result generation reactive species (ROS) eradicate cells while inducing immunogenic cell death (ICD) activate anti-tumor responses. In addition, reprogram TAM from pro-tumor M2 phenotype tumor-killing M1 well, thereby reversing immunosuppressive microenvironment. Taken together, current study provides an innovative perspective on development novel nanomaterials limitations immunotherapy.

Language: Английский

Citations

74
A Unified Therapeutic–Prophylactic Tissue‐Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling DOI
Yongkang Huang, Xinyun Zhai, Tengfei Ma

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: March 20, 2023

Osteosarcoma occurs in children and adolescents frequently leads to a high fatality rate. Although surgical resection is the most common methods clinic, patients always suffer from tumor metastasis recurrence it difficult for them self-repair large bone defects. Furthermore, postoperative infection bacteria triggers an inflammatory response hinders bone-repair process. This work demonstrates gadolinium (Gd)-complex molybdenum sulfide (MoS2 ) co-doped N-acryloyl glycinamide (NAGA)/gelatin methacrylate (Gel-MA) multifunctional hydrogel (GMNG). The combination between NAGA Gel-MA endows GMNG with attractive mechanical properties controllable degradation ability. MoS2 improves system, which has excellent photothermal ability kill cells inhibit bacterial both vitro vivo. Based on Gd-complex, magnetic resonance imaging (MRI) effect can be used monitor position situation of hydrogel. Notably, accompanied by hydrogel, gradually released Gd3+ exhibits osteogenic property could promote new formation efficiently Therefore, this strategy supplies method prepare bone-defect-repair materials expected represent significant guidance reference development biomaterials tissue engineering.

Language: Английский

Citations

67
Metal-organic framework nanoshell structures: Preparation and biomedical applications DOI
Jia Tang, Chenyi Huang, Yuanqi Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 490, P. 215211 - 215211

Published: May 12, 2023

Language: Английский

Citations

58
OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy DOI
Yongkang Yu, Tingxuan Li,

Meitong Ou

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 365, P. 469 - 479

Published: Dec. 2, 2023

Language: Английский

Citations

56
Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment DOI
Qinrui Fu,

Chuang Wei,

Mengzhen Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

Citations

56
Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications DOI
Xianbo Wu, Yuqing Li, Mei Wen

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

Citations

40