Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 12, 2025
Mitochondria
play
a
significant
role
in
several
cellular
activities
and
their
function
health
disease
has
become
an
important
area
of
research.
Since
the
brain
is
high-energy-demanding
organ,
it
particularly
vulnerable
to
mitochondrial
dysfunction.
This
been
implicated
disorders
including
neurodegenerative,
psychiatric
neurological
disorders,
e.g.,
Parkinson’s
schizophrenia.
Significant
efforts
are
underway
develop
mitochondria-targeting
pharmaceutical
interventions.
However,
complex
membrane
network
restricts
entry
therapeutic
compounds
into
matrix.
Nanoparticles
(NPs)
present
novel
solution
this
limitation,
while
also
increasing
stability
moieties
improving
bioavailability.
article
provides
detailed
overview
studies
that
have
investigated
treatment
dysfunction
using
either
targeted
or
non-targeted
NPs
as
drug
delivery
systems.
All
showed
improved
functioning
reduction
reactive
oxygen
species
(ROS)
production,
improvement
overall
respiration
reversal
toxin-induced
damage.
mitochondrial-targeted
advantage
over
they
were
able
improve
rescue
dynamics
biogenesis,
required
lower
concentration
vivo
dosage
load
show
effect.
Consequently,
mitochondria-targeted
promising
approach.
Future
should
exploit
advances
nanotechnology,
neuroscience
chemistry
design
can
cross
blood-brain
barrier
selectively
target
dysfunctional
mitochondria,
outcomes.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(22)
Published: May 18, 2023
Abstract
Mitochondrial
dysfunction
of
neurons
is
the
core
pathogenesis
incurable
Parkinson's
disease
(PD).
It
crucial
to
ameliorate
mitochondrial
for
boosting
therapy
PD.
Herein,
remarkable
promotion
biogenesis
and
improve
treatment
PD
by
using
mitochondria‐targeted
biomimetic
nanoparticles,
which
are
Cu
2‐
x
Se‐based
nanoparticles
functionalized
with
curcumin
wrapped
DSPE‐PEG
2000
‐TPP‐modified
macrophage
membrane
(denoted
as
CSCCT
NPs),
reported.
These
can
efficiently
target
mitochondria
damaged
in
an
inflammatory
environment,
mediate
signaling
pathway
NAD
+
/SIRT1/PGC‐1
α
/PPAR
γ
/NRF1/TFAM
alleviate
1‐methyl‐4‐phenylpyridinium
(MPP
)‐induced
neuronal
toxicity.
They
reduce
reactive
oxygen
species,
restore
potential
(MMP),
protect
integrity
respiratory
chain,
via
promoting
biogenesis,
synergistically
motor
disorders
anxiety
behavior
1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine
(MPTP)‐induced
mice.
This
study
demonstrates
that
targeting
has
a
great
mitochondria‐related
diseases.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 15, 2024
Abstract
Mitochondria,
widely
known
as
the
energy
factories
of
eukaryotic
cells,
have
a
myriad
vital
functions
across
diverse
cellular
processes.
Dysfunctions
within
mitochondria
serve
catalysts
for
various
diseases,
prompting
widespread
demise.
Mounting
research
on
remedying
damaged
indicates
that
constitute
valuable
target
therapeutic
intervention
against
diseases.
But
less
clinical
practice
and
lower
recovery
rate
imply
limitation
traditional
drugs,
which
need
further
breakthrough.
Nanotechnology
has
approached
favorable
regiospecific
biodistribution
high
efficacy
by
capitalizing
excellent
nanomaterials
targeting
drug
delivery.
Mitochondria‐remedying
nanodrugs
achieved
ideal
effects.
This
review
elucidates
significance
in
cells
organs,
while
also
compiling
mortality
data
related
Correspondingly,
nanodrug‐mediate
strategies
applicable
mitochondria‐remedying
disease
are
detailed,
with
full
understanding
roles
dysfunction
advantages
nanodrugs.
In
addition,
future
challenges
directions
discussed.
conclusion,
this
provides
comprehensive
insights
into
design
development
nanodrugs,
aiming
to
help
scientists
who
desire
extend
their
fields
engage
interdisciplinary
subject.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 1, 2024
Abstract
Background
Herbal
nanoparticles
are
made
from
natural
herbs/medicinal
plants,
their
extracts,
or
a
combination
with
other
nanoparticle
carriers.
Compared
to
traditional
herbs,
herbal
lead
improved
bioavailability,
enhanced
stability,
and
reduced
toxicity.
Previous
research
indicates
that
medicine
nanomaterials
rapidly
advancing
making
significant
progress;
however,
bibliometric
analysis
knowledge
mapping
for
currently
lacking.
We
performed
by
retrieving
publications
related
the
Web
of
Science
Core
Collection
(WoSCC)
database
spanning
2004
2023.
Data
processing
was
using
R
package
Bibliometrix,
VOSviewers,
CiteSpace.
Results
In
total,
1876
articles
were
identified,
originating
various
countries,
China
being
primary
contributing
country.
The
number
in
this
field
increases
annually.
Beijing
University
Chinese
Medicine,
Shanghai
Traditional
Saveetha
India
prominent
institutions
domain.
Journal
“International
Nanomedicine”
has
highest
publications.
authors
these
reached
8234,
Yan
Zhao,
Yue
Zhang,
Huihua
Qu
most
prolific
Zhao
frequently
cited
author.
“Traditional
medicine,”
“drug
delivery,”
“green
synthesis”
main
focal
points.
Themes
such
as
synthesis,”
“curcumin,”
“wound
healing,”
“carbon
dots”
may
represent
emerging
areas.
Conclusions
Our
study
findings
assist
identifying
latest
frontiers
hot
topics,
providing
valuable
references
scholars
investigating
role
nanotechnology
medicine.
Graphical
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10494 - 10494
Published: June 22, 2023
Liposomes
modified
with
tetradecyltriphenylphosphonium
bromide
dual
loading
of
α-tocopherol
and
donepezil
hydrochloride
were
successfully
designed
for
intranasal
administration.
Physicochemical
characteristics
cationic
liposomes
such
as
the
hydrodynamic
diameter,
zeta
potential,
polydispersity
index
within
range
from
105
to
115
nm,
+10
+23
mV,
0.1
0.2,
respectively.
In
vitro
release
curves
analyzed
using
Korsmeyer-Peppas,
Higuchi,
First-Order,
Zero-Order
kinetic
models.
Nanocontainers
surfactant
statistically
better
penetrate
into
mitochondria
rat
motoneurons.
Imaging
brain
slices
revealed
penetration
nanocarriers
brain.
Experiments
on
transgenic
mice
an
Alzheimer's
disease
model
(APP/PS1)
demonstrated
that
administration
21
days
resulted
in
enhanced
learning
abilities
a
reduction
formation
rate
Aβ
plaques
entorhinal
cortex
hippocampus
