Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(11)
Published: Jan. 27, 2023
Abstract
Organic
photothermal
cocrystals,
integrating
the
advantages
of
intrinsic
organic
cocrystals
and
fascinating
conversion
ability,
hold
attracted
considerable
interest
in
both
basic
science
practical
applications,
involving
photoacoustic
imaging,
seawater
desalination,
therapy,
so
on.
However,
these
currently
suffer
individual
cases
discovered
step
by
step,
as
well
deep
systemic
investigation
corresponding
mechanisms
is
rarely
carried
out,
suggesting
a
huge
challenge
for
their
further
developments.
Therefore,
it
urgently
necessary
to
investigate
explore
rational
design
synthesis
high‐performance
future
applications.
This
review
first
systematically
summarizes
cocrystal
terms
molecular
classification,
mechanism,
The
timely
interpretation
effect
will
provide
broad
prospects
purposeful
fabrication
excellent
toward
great
efficiency,
low
cost,
multifunctionality.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: April 20, 2020
Despite
its
growing
promise
in
cancer
treatment,
ferrotherapy
has
low
therapeutic
efficacy
due
to
compromised
Fenton
catalytic
efficiency
tumor
milieu.
We
herein
report
a
hybrid
semiconducting
nanozyme
(HSN)
with
high
photothermal
conversion
for
photoacoustic
(PA)
imaging-guided
second
near-infrared
ferrotherapy.
HSN
comprises
an
amphiphilic
polymer
as
converter,
PA
emitter
and
iron-chelating
catalyst.
Upon
photoirradiation,
generates
heat
not
only
induce
cytotoxicity
but
also
enhance
reaction.
The
increased
·OH
generation
promotes
both
ferroptosis
apoptosis,
oxidizes
(42
nm)
transforms
it
into
tiny
segments
(1.7
elevated
intratumoral
permeability.
non-invasive
seamless
synergism
leads
amplified
effects
including
deep
ablation
depth
(9
mm),
reduced
expression
of
metastasis-related
proteins
inhibition
metastasis
from
primary
distant
organs.
Thereby,
our
study
provides
generalized
strategy
compensate
phototherapeutics
complete
regression.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
59(26), P. 10633 - 10638
Published: March 24, 2020
Abstract
This
study
reports
the
development
of
iron‐chelated
semiconducting
polycomplex
nanoparticles
(SPFeN)
for
photoacoustic
(PA)
imaging‐guided
photothermal
ferrotherapy
cancer.
The
hybrid
polymeric
nanoagent
comprises
a
ferroptosis
initiator
(Fe
3+
)
and
an
amphiphilic
(SP
C
serving
as
both
nanotransducer
iron
ion
chelator.
By
virtue
poly(ethylene
glycol)
(PEG)
grafting
its
small
size,
SPFeN
accumulates
in
tumor
living
mice
after
systemic
administration,
which
can
be
monitored
by
PA
imaging.
In
acidic
microenvironment,
generates
hydroxyl
radicals,
leading
to
ferroptosis;
meanwhile,
under
NIR
laser
irradiation,
it
localized
heat
not
only
accelerate
Fenton
reaction
but
also
implement
therapy.
Such
combined
ferrotherapeutic
effect
leads
minimized
dosage
compared
previous
studies
effectively
inhibits
growth
mice,
is
possible
controls.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(43), P. 18233 - 18241
Published: Oct. 22, 2021
Light-induced
heat
is
largely
neglected
in
traditional
photocatalytic
systems,
especially
for
the
thermodynamically
and
kinetically
challenging
CO2
reduction
to
C2
fuels.
Herein,
we
first
design
asymmetric
Metal1-O-Metal2
triple-atom
sites
confined
phenakite
facilitate
C-C
coupling
employ
photoinduced
increase
molecular
thermal
vibration
accelerate
Using
O-vacancy-rich
Zn2GeO4
nanobelts
as
prototypes,
quasi
situ
Raman
spectra
disclose
Zn-O-Ge
triatomic
are
likely
reactive
sites.
Density
functional
theory
calculations
reveal
that
could
promote
through
inducing
distinct
charge
distributions
of
neighboring
C1
intermediates,
whereas
created
O
vacancies
lower
energy
barrier
rate-determining
hydrogenation
step
from
1.46
0.67
eV.
Catalytic
performances
under
different
testing
conditions
demonstrate
light
initiates
reaction.
In
Fourier-transform
infrared
D2O
kinetic
isotopic
effect
experiments
light-induced
triggers
accelerates
OCCO*
via
providing
abundant
hydrogen
species.
Consequently,
a
simulated
air
atmosphere
0.1
W/cm2
illumination
at
348
K,
an
acetate
output
12.7
μmol
g-1
h-1,
high
selectivity
66.9%,
considerable
CO2-to-CH3COOH
conversion
ratio
29.95%,
stability
up
220
h.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(5), P. 2360 - 2367
Published: Jan. 20, 2022
Considering
that
hypoxia
is
closely
associated
with
tumor
proliferation,
invasion,
metastasis,
and
drug
resistance,
it
of
great
significance
to
overcome
in
treatment.
Herein,
we
report
a
hypoxia-induced
specific
photothermal
therapy
(PTT)
based
on
the
agent
supramolecular
perylene
diimide
radical
anions.
Hypoxic
regions
various
tumors
display
strong
reductive
ability,
such
environments
complex
derivative
cucurbit[7]uril
could
be
reduced
Benefiting
from
NIR
absorption
good
conversion
performance
situ
generated
anions,
PTT
strategy
exhibits
excellent
therapeutic
efficiency
as
well
specificity
biological
safety.
Moreover,
inducible
factor
expression
decreases
normal
level
after
It
anticipated
opens
new
horizons
for
against
hypoxic
improved
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(34), P. 13980 - 13989
Published: Aug. 24, 2021
Most
photodynamic
therapy
(PDT)
paradigms
work
through
the
highly
O2-dependent
type
II
photoreaction
to
generate
singlet
oxygen
(1O2).
The
hypoxic
microenvironment
of
solid
tumors
severely
hampers
therapeutic
outcomes.
Here,
we
present
a
novel
design
that
could
transfer
photophysical
and
photochemical
properties
traditional
phthalocyanine-based
photosensitizers
from
efficient
I
vibrational
relaxation-induced
photothermal
conversion.
These
features
enable
obtained
nanostructured
phthalocyanine
assemblies
(e.g.,
NanoPcAF)
display
excellent
phototherapies
under
both
normoxic
conditions.
Moreover,
NanoPcAF
has
high
level
accumulation
in
tumor
tissues
after
intravenous
injection,
94%
growth
is
inhibited
preclinical
model
at
dose
0.8
nmol
g–1
light
300
J
cm–2.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(21)
Published: April 19, 2021
Abstract
Pancreatic
cancer,
one
of
the
most
lethal
malignancies,
compromises
performance
traditional
therapeutic
regimens
in
clinic
because
stromal
resistance
to
systemic
drug
delivery
and
poor
prognosis
caused
by
tumor
metastasis.
Therefore,
a
biocompatible
paradigm
that
can
effectively
inhibit
pancreatic
growth
while
simultaneously
eliminating
metastasis
is
urgently
needed.
Herein,
supramolecular
nanofibrils
are
fabricated
through
coassembly
clinically
approved
immunomodulatory
thymopentin
near‐infrared
indocyanine
green
for
localized
photothermal
immunotherapy
tumors.
The
resulting
long‐range
ordered
fibrous
nanodrugs
show
improved
photophysical
capabilities
fluorescence
imaging
conversion
significantly
promote
proliferation
differentiation
antitumor
immune
cells.
Hence,
integration
rapid
therapy
moderate
immunomodulation
inhibiting
promising.
utilization
molecules
construct
administered
via
injection
amplifies
complementary
immunotherapeutic
effects
components,
creating
opportunities
clinical
translation
as
treatment
cancer.
