Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215426 - 215426

Published: Sept. 6, 2023

Language: Английский

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NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(38)

Published: July 18, 2022

Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano‐sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining application SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich vacancies developed interlayer gaps trioxide nanobelts expanded. Owing to increased vacancy density wide gap‐induced narrower band gap SMB NPs, electrons (e – ) holes (h + generated by US separated more rapidly, prevent electrons–holes recombination under irradiation. NPs exhibit second near‐infrared (NIR‐II) photothermal effect promote generation ROS sonosensitizer. The system is successfully realized eliminate Staphylococcus aureus ( S. dissipate biofilm. Therefore, multimodal using serves as an effective promising regimen for deep‐seated bacterial infections. newly Mo‐based sonosensitizer presented first time demonstrate excellent antimicrobial activity through hyperthermia‐promoting SDT therapeutics. This work proposes novel strategy field NIR‐II photo‐amplified materials eradication other important biomedical applications.

Language: Английский

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Photothermal-based nanomaterials and photothermal-sensing: An overview

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 220, P. 114883 - 114883

Published: Nov. 5, 2022

Language: Английский

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Polysaccharide-based hydrogel with photothermal effect for accelerating wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 299, P. 120228 - 120228

Published: Oct. 14, 2022

Language: Английский

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Growth of ZIF-8 Nanoparticles In Situ on Graphene Oxide Nanosheets: A Multifunctional Nanoplatform for Combined Ion-Interference and Photothermal Therapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 11428 - 11443

Published: July 11, 2022

The regulation of intracellular ions' overload to interrupt normal bioprocesses and cause cell death has been developed as an efficient strategy (named ion-interference therapy/IIT) treat cancer. In this study, we design a multifunctional nanoplatform (called BSArGO@ZIF-8 NSs) by in situ growth metal organic framework nanoparticles (ZIF-8 NPs) onto the graphene oxide (GO) surface, subsequently reduced ascorbic acid modified bovine serum albumin. This nanocomplex causes Zn2+, increase reactive oxygen species (ROS), exerts broad-spectrum lethality different kinds cancer cells. NSs can promote apoptosis initiating bim (a pro-apoptotic protein)-mediated mitochondrial apoptotic events, up-regulating PUMA/NOXA expression, down-regulating level Bid/p53AIP1. Meanwhile, Zn2+ excess triggers cellular dysfunction mitochondria damage activating autophagy signaling pathways disturbing environmental homeostasis. Combined with photothermal effect GO (rGO), mediated combined therapy leads effective inhibits proliferation angiogenesis, bringing higher efficacy tumor suppression vivo. designed Zn-based will allow promoting further development IIT corresponding strategy.

Language: Английский

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Cell membrane biomimetic nanomedicines for cancer phototherapy

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: Feb. 21, 2023

Abstract Phototherapy, mainly including photothermal therapy (PTT) and photodynamic (PDT), can kill cancer cells by generating heat or reactive oxygen species, which has the advantages of being minimally invasive, high efficiency, low toxicity. However, traditional phototherapeutic agents face challenges such as poor tumor targeting, susceptibility to passive immune clearance, suboptimal biocompatibility, limit their clinical application. Recently, cell membrane biomimetic technology endows with unique biological functions, promoted escape, prolonged in vivo circulation time, improved enhanced anti‐tumor efficacy. In addition, phototherapy mediated (CCM) membrane‐modified promote broad immunity. this review, we deeply analyze mechanisms PTT PDT, systematically discuss synthesis strategies functions nanomaterials, focus on progress based nanomaterials synergistic therapies chemotherapy, radiotherapy, immunotherapy, sonodynamic therapy. Finally, address opportunities future prospects field phototherapy. This comprehensive review is expected provide insights into promoting translation agents.

Language: Английский

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

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Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6349 - 6349

Published: March 28, 2023

With advances in nanotechnology, nanoparticles have come to be regarded as carriers of therapeutic agents and been widely studied overcome various diseases the biomedical field. Among these particles, mesoporous silica (MSNs) investigated potential nanocarriers deliver drug molecules target sites body. This review introduces physicochemical properties MSNs synthesis procedures MSN-based nanoplatforms. Moreover, we focus on updating applications a carrier or diagnostic cargo clinical trials using silica-nanoparticle-based systems. Herein, one hand, pay attention pharmaceutical advantages MSNs, including nanometer particle size, high surface area, porous structures, thus enabling efficient delivery drug-loading content. On other look through biosafety toxicity issues associated with platforms. Based many reports so far, applied construct tissue engineering platforms well treat diseases, cancer, by functionalization incorporation stimuli-responsive components. However, even advantageous aspects that possess, there are still considerations, such optimizing dosage regimens, regarding use clinics. Progress scale-up production thorough investigation into would enable design innovative safe fields.

Language: Английский

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