Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma DOI Creative Commons
Jiaying Zhou, Wenjin Wang, Chenyu Zhang

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 289, P. 121757 - 121757

Published: Aug. 24, 2022

The alternations in the hypoxic and immune microenvironment are closely related to therapeutic effect prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO2@[email protected] is constructed from ruthenium-based photosensitizer (Ru) modified-TiO2 nanoparticles (NPs) loaded with siRNA hypoxia-inducible factor-1α (HIF-1α). Under visible light irradiation, can elicit both Type I II photodynamic effects, which causes lysosomal damage, HIF-1α gene silencing, OSCC elimination efficiently. As consequence hypoxia relief pyroptosis induction, reshapes by downregulation key immunosuppressive factors, upregulation cytokines, activation CD4+ CD8+ T lymphocytes. Furthermore, patient-derived xenograft (PDX) rat experimental carcinogenesis models prove that protected]-mediated therapy significantly inhibits tumor growth progression, markedly enhances cancer immunity. In all, this study presents an effective hypoxia-adaptive photo-immunotherapeutic nanosystem great potential for prevention treatment.

Language: Английский

Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy DOI
Kun‐Xu Teng, Li‐Ya Niu, Qing‐Zheng Yang

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4081 - 4087

Published: Feb. 13, 2023

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop oxygen-independent supramolecular agent that produces hydroxyl radical (•OH) by oxidizing water the presence intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as electron donor and coassembled with perylene diimide acceptor form quadruple hydrogen-bonded agent. Detailed mechanism studies reveal intermolecular transfer charge separation upon light irradiation result efficient generation ion pairs. Under conditions, cationic radicals directly oxidize generate cytotoxic •OH, anionic electrons acid, realizing catalytic cycle. Thus, this exhibited superb photocytotoxicity even severe environments excellent vivo antitumor on HeLa-bearing mouse models. This work provides a strategy for constructing agents, opens up avenue effective PDT tumors.

Language: Английский

Citations

223

In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity DOI
Hua Wang,

Ke-Fei Xue,

Yuchong Yang

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(5), P. 2360 - 2367

Published: Jan. 20, 2022

Considering that hypoxia is closely associated with tumor proliferation, invasion, metastasis, and drug resistance, it of great significance to overcome in treatment. Herein, we report a hypoxia-induced specific photothermal therapy (PTT) based on the agent supramolecular perylene diimide radical anions. Hypoxic regions various tumors display strong reductive ability, such environments complex derivative cucurbit[7]uril could be reduced Benefiting from NIR absorption good conversion performance situ generated anions, PTT strategy exhibits excellent therapeutic efficiency as well specificity biological safety. Moreover, inducible factor expression decreases normal level after It anticipated opens new horizons for against hypoxic improved

Language: Английский

Citations

189

Theranostic Fluorescent Probes DOI Creative Commons
Amit Sharma, Peter Verwilst, Mingle Li

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

Citations

139

Amino‐Acid‐Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy DOI
Rui Chang, Qianli Zou, Luyang Zhao

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(16)

Published: Feb. 18, 2022

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type dominates assembled nanostructures, structural stability, energy-conversion pathway, mechanism resulting nanodrugs. Two optimized are endowed robust integrity against disassembly along high conversion efficiency, efficient cellular internalization, enhanced tumor accumulation, which result in more ablation. This work demonstrates offers an unprecedented opportunity construction remarkable photoactive nanomedicines toward diagnostics therapeutics.

Language: Английский

Citations

135

A host–guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator DOI Creative Commons
Kun‐Xu Teng, Li‐Ya Niu, Qing‐Zheng Yang

et al.

Chemical Science, Journal Year: 2022, Volume and Issue: 13(20), P. 5951 - 5956

Published: Jan. 1, 2022

A supramolecular strategy is reported for converting the conventional photodynamic agents from a singlet oxygen generator to superoxide radical by host–guest interaction enhanced electron transfer.

Language: Английский

Citations

132

Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical DOI Creative Commons
Kun‐Xu Teng, Li‐Ya Niu,

Nan Xie

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 19, 2022

Abstract Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare PSs is of great importance, but remains a challenge. Here, we report supramolecular strategy for the preparation photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors existing Type-II PSs. As proof-of-concept, three were designed co-assembled with classical PS produce quadruple hydrogen-bonded agents. The photo-induced transfer from adjacent acceptor occurs efficiently, leading generation +• an anionic radical acceptor, further transfers oxygen form O 2 −• . In addition, these agents induce direct photocatalytic oxidation NADH turnover frequency as high 53.7 min −1 , offers oxygen-independent mechanism damage tumors.

Language: Английский

Citations

128

Tumor-derived exosomes co-delivering aggregation-induced emission luminogens and proton pump inhibitors for tumor glutamine starvation therapy and enhanced type-I photodynamic therapy DOI
Daoming Zhu, Tianfu Zhang, Li Yang

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 283, P. 121462 - 121462

Published: March 5, 2022

Language: Английский

Citations

107

Reactivity Differences Enable ROS for Selective Ablation of Bacteria DOI
Xiaofeng Wu, Mengyao Yang, Ji‐Seon Kim

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(17)

Published: Feb. 17, 2022

An effective strategy to engineer selective photodynamic agents surmount bacterial-infected diseases, especially Gram-positive bacteria remains a great challenge. Herein, we developed two examples of compounds for proof-of-concept study where reactive differences in oxygen species (ROS) can induce ablation bacteria. Sulfur-replaced phenoxazinium (NBS-N) mainly generates superoxide anion radical capable selectively killing bacteria, while selenium-substituted (NBSe-N) has higher generation singlet that kill both and Gram-negative This difference was further evidenced by bacterial fluorescence imaging morphological changes. Moreover, NBS-N also successfully heal the bacteria-infected wounds mice. We believe such may pave general way design ablating diseases.

Language: Английский

Citations

98

Carrier-free nanomedicines for cancer treatment DOI
Li‐Han Liu, Xian‐Zheng Zhang

Progress in Materials Science, Journal Year: 2022, Volume and Issue: 125, P. 100919 - 100919

Published: Jan. 4, 2022

Language: Английский

Citations

95

Photodynamic-based combinatorial cancer therapy strategies: Tuning the properties of nanoplatform according to oncotherapy needs DOI
Chen Chen,

Changsong Wu,

Jiming Yu

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 461, P. 214495 - 214495

Published: March 12, 2022

Language: Английский

Citations

77