Biomaterials,
Journal Year:
2022,
Volume and Issue:
289, P. 121757 - 121757
Published: Aug. 24, 2022
The
alternations
in
the
hypoxic
and
immune
microenvironment
are
closely
related
to
therapeutic
effect
prognosis
of
oral
squamous
cell
carcinoma
(OSCC).
Herein,
a
new
nanocomposite,
TiO2@[email
protected]
is
constructed
from
ruthenium-based
photosensitizer
(Ru)
modified-TiO2
nanoparticles
(NPs)
loaded
with
siRNA
hypoxia-inducible
factor-1α
(HIF-1α).
Under
visible
light
irradiation,
can
elicit
both
Type
I
II
photodynamic
effects,
which
causes
lysosomal
damage,
HIF-1α
gene
silencing,
OSCC
elimination
efficiently.
As
consequence
hypoxia
relief
pyroptosis
induction,
reshapes
by
downregulation
key
immunosuppressive
factors,
upregulation
cytokines,
activation
CD4+
CD8+
T
lymphocytes.
Furthermore,
patient-derived
xenograft
(PDX)
rat
experimental
carcinogenesis
models
prove
that
protected]-mediated
therapy
significantly
inhibits
tumor
growth
progression,
markedly
enhances
cancer
immunity.
In
all,
this
study
presents
an
effective
hypoxia-adaptive
photo-immunotherapeutic
nanosystem
great
potential
for
prevention
treatment.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 4081 - 4087
Published: Feb. 13, 2023
The
highly
oxygen-dependent
nature
of
photodynamic
therapy
(PDT)
limits
its
therapeutic
efficacy
against
hypoxic
solid
tumors
in
clinics,
which
is
an
urgent
problem
to
be
solved.
Herein,
we
develop
oxygen-independent
supramolecular
agent
that
produces
hydroxyl
radical
(•OH)
by
oxidizing
water
the
presence
intracellularly
abundant
pyruvic
acid
under
oxygen-free
conditions.
A
fluorene-substituted
BODIPY
was
designed
as
electron
donor
and
coassembled
with
perylene
diimide
acceptor
form
quadruple
hydrogen-bonded
agent.
Detailed
mechanism
studies
reveal
intermolecular
transfer
charge
separation
upon
light
irradiation
result
efficient
generation
ion
pairs.
Under
conditions,
cationic
radicals
directly
oxidize
generate
cytotoxic
•OH,
anionic
electrons
acid,
realizing
catalytic
cycle.
Thus,
this
exhibited
superb
photocytotoxicity
even
severe
environments
excellent
vivo
antitumor
on
HeLa-bearing
mouse
models.
This
work
provides
a
strategy
for
constructing
agents,
opens
up
avenue
effective
PDT
tumors.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(5), P. 2360 - 2367
Published: Jan. 20, 2022
Considering
that
hypoxia
is
closely
associated
with
tumor
proliferation,
invasion,
metastasis,
and
drug
resistance,
it
of
great
significance
to
overcome
in
treatment.
Herein,
we
report
a
hypoxia-induced
specific
photothermal
therapy
(PTT)
based
on
the
agent
supramolecular
perylene
diimide
radical
anions.
Hypoxic
regions
various
tumors
display
strong
reductive
ability,
such
environments
complex
derivative
cucurbit[7]uril
could
be
reduced
Benefiting
from
NIR
absorption
good
conversion
performance
situ
generated
anions,
PTT
strategy
exhibits
excellent
therapeutic
efficiency
as
well
specificity
biological
safety.
Moreover,
inducible
factor
expression
decreases
normal
level
after
It
anticipated
opens
new
horizons
for
against
hypoxic
improved
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2699 - 2804
Published: Feb. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(16)
Published: Feb. 18, 2022
Photothermal
nanomedicine
based
on
self-assembly
of
biological
components,
with
excellent
biosafety
and
customized
performance,
is
vital
significance
for
precision
cancer
therapy.
However,
the
programmable
design
photothermal
remains
extremely
challenging
due
to
vulnerability
variability
noncovalent
interactions
governing
supramolecular
self-assembly.
Herein,
it
reported
that
amino
acid
encoding
a
facile
potent
means
construct
nanodrugs
controlled
therapeutic
activities.
It
found
amount
type
dominates
assembled
nanostructures,
structural
stability,
energy-conversion
pathway,
mechanism
resulting
nanodrugs.
Two
optimized
are
endowed
robust
integrity
against
disassembly
along
high
conversion
efficiency,
efficient
cellular
internalization,
enhanced
tumor
accumulation,
which
result
in
more
ablation.
This
work
demonstrates
offers
an
unprecedented
opportunity
construction
remarkable
photoactive
nanomedicines
toward
diagnostics
therapeutics.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(20), P. 5951 - 5956
Published: Jan. 1, 2022
A
supramolecular
strategy
is
reported
for
converting
the
conventional
photodynamic
agents
from
a
singlet
oxygen
generator
to
superoxide
radical
by
host–guest
interaction
enhanced
electron
transfer.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Oct. 19, 2022
Abstract
Given
that
Type-I
photosensitizers
(PSs)
have
hypoxia
tolerance,
developing
general
approaches
to
prepare
PSs
is
of
great
importance,
but
remains
a
challenge.
Here,
we
report
supramolecular
strategy
for
the
preparation
photodynamic
agents,
which
simultaneously
generate
strong
oxidizing
cationic
radicals
and
superoxide
radicals,
by
introducing
electron
acceptors
existing
Type-II
PSs.
As
proof-of-concept,
three
were
designed
co-assembled
with
classical
PS
produce
quadruple
hydrogen-bonded
agents.
The
photo-induced
transfer
from
adjacent
acceptor
occurs
efficiently,
leading
generation
+•
an
anionic
radical
acceptor,
further
transfers
oxygen
form
O
2
−•
.
In
addition,
these
agents
induce
direct
photocatalytic
oxidation
NADH
turnover
frequency
as
high
53.7
min
−1
,
offers
oxygen-independent
mechanism
damage
tumors.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(17)
Published: Feb. 17, 2022
An
effective
strategy
to
engineer
selective
photodynamic
agents
surmount
bacterial-infected
diseases,
especially
Gram-positive
bacteria
remains
a
great
challenge.
Herein,
we
developed
two
examples
of
compounds
for
proof-of-concept
study
where
reactive
differences
in
oxygen
species
(ROS)
can
induce
ablation
bacteria.
Sulfur-replaced
phenoxazinium
(NBS-N)
mainly
generates
superoxide
anion
radical
capable
selectively
killing
bacteria,
while
selenium-substituted
(NBSe-N)
has
higher
generation
singlet
that
kill
both
and
Gram-negative
This
difference
was
further
evidenced
by
bacterial
fluorescence
imaging
morphological
changes.
Moreover,
NBS-N
also
successfully
heal
the
bacteria-infected
wounds
mice.
We
believe
such
may
pave
general
way
design
ablating
diseases.
