Golgi-targeting viscosity probe for the diagnosis of Alzheimer’s disease DOI Creative Commons
Wenjing Wu,

Lingyu Zhao,

Yuanyuan Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 16, 2024

Abstract Early diagnosis and intervention of Alzheimer’s disease (AD) are particularly important to delay the pathological progression. Although fluorescent probes have been widely employed for investigating diagnosing AD, their biological applications significantly restricted due low penetration ability blood–brain barrier (BBB) in vivo. In this study, we reported first Golgi-targeted two-photon (TP) probe, DCM-DH, detecting viscosity Golgi apparatus. The probe was rationally designed exhibit superior analytical performance including high sensitivity, specific Golgi-targeting, efficient BBB ability, deep tissue (247 μm) brains AD model mice. Using demonstrated that fluorescence intensity human liver cancer cell (HepG2 cells) higher than normal (LO2 cells), brain mice increased significantly. We anticipate competent tool could be easily extended other biomarkers fundamental research on detrimental disease.

Language: Английский

Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy DOI
Hui Li, Yujun Kim,

Hyoje Jung

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

Citations

220
Quasi-LD-Targeted and ONOO–-Responsive Fluorescent Probe for Investigating the Interaction of Nonalcoholic Fatty Liver with Drug-Induced Liver Injury DOI

Nannan Wang,

Xiaoyan Lu, Jiamin Wang

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(14), P. 5967 - 5975

Published: March 29, 2023

Hepatic lipid droplets (LDs) and peroxynitrite (ONOO-) levels are closely related to nonalcoholic fatty liver disease (NAFLD). Additionally, some drug-induced injury (DILI) is often associated with ONOO-. Here, we constructed screened the quasi-LDs-targeted ONOO--responsive fluorescent probe MBDP-Py+ investigate interaction of NAFLD DILI. By monitoring upregulation ONOO- accumulation LDs, was more sensitive efficient than tissue staining serum markers detection in evaluating early toxicity diagnosing anticancer-DILI. More importantly, enhancement fluorescence signals demonstrated that different stages NAFLD, dominant element combined DILI mice models. As degree deepens, synergistic effect two will lead serious damage.

Language: Английский

Citations

91
Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives DOI
Yufan Fan, Yue Wu, Jie Hou

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 480, P. 215020 - 215020

Published: Jan. 25, 2023

Language: Английский

Citations

77
Recent advances in small-molecule fluorescent probes for diagnosis of cancer cells/tissues DOI
Kun Wang, Caiyun Liu,

Hanchuang Zhu

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 477, P. 214946 - 214946

Published: Dec. 9, 2022

Language: Английский

Citations

70
Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging DOI
Lixuan Dai, Qian Zhang, Qingqing Ma

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 489, P. 215193 - 215193

Published: May 6, 2023

Language: Английский

Citations

61
Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window DOI
Baisong Chang, Jie Chen,

Jiasheng Bao

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

Citations

48
A Space‐Dependent ‘Enzyme‐Substrate’ Type Probe based on ‘Carboxylesterase‐Amide Group’ for Ultrafast Fluorescent Imaging Orthotopic Hepatocellular Carcinoma DOI Creative Commons
Ying Wen, Jing Ning, Min Zhang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(8)

Published: Jan. 18, 2023

Abstract Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis remains significant challenge due complex physical environment. Human carboxylesterase (CE) is expected be potential of hepatocellular carcinoma (HCC) improve the accuracy diagnosis. However, existing probes CE has slow response rate low selectivity. Herein, amide group selected as CE‐responsive sites based on “substrate‐hydrolysis enzymatic reaction” approach. From series off–on with leave groups in unit, probe J screened optimal combination rapid high selectivity toward CE. requires only 150 s reach maximum at 676 nm presence free from interference other esterase. Computational docking simulations indicate shortest distance between active site . Cell vivo present that can turn liver cancer cells tumor region precisely. Importantly, allowed specifically image orthotopic rather than metastatic distinguish human primary tissue adjacent ones. This study provides new tool detection promotes advancements accurate HCC

Language: Английский

Citations

44
Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

21
Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets DOI

Mingyue Cao,

Yunting Liu,

Caihong Xiang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216181 - 216181

Published: Sept. 5, 2024

Language: Английский

Citations

19
Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field DOI Creative Commons
Qian He,

Meiyiming Wang,

Zhao Li

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

Citations

17