Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Language: Английский

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A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(7)

Published: Jan. 17, 2023

Abstract Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in field chemodynamic therapy (CDT). However, exact mechanism CDT is obscured by unique tumor chemical environment inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, significance clarified, complex deconstructed primitive biological research directions based on kinetics signaling pathways are discussed detail. Moreover, beneficial outlooks presented enlighten evolution next‐generation CDT. Hopefully, Perspective can inspire new ideas advances for provide a reference breaking down interdisciplinary barriers nanomedicine.

Language: Английский

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Recent advances in targeted antibacterial therapy basing on nanomaterials

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Feb. 1, 2023

Bacterial infection has become one of the leading causes death worldwide, particularly in low-income countries. Despite fact that antibiotics have provided successful management bacterial infections, long-term overconsumption and abuse contributed to emergence multidrug resistant bacteria. To address this challenge, nanomaterials with intrinsic antibacterial properties or serve as drug carriers been substantially developed an alternative fight against infection. Systematically deeply understanding mechanisms is extremely important for designing new therapeutics. Recently, nanomaterials-mediated targeted bacteria depletion either a passive active manner most promising approaches treatment by increasing local concentration around cells enhance inhibitory activity reduce side effects. Passive targeting approach widely explored searching nanomaterial-based alternatives antibiotics, while strategy relies on biomimetic biomolecular surface feature can selectively recognize In review article, we summarize recent developments field therapy based nanomaterials, which will promote more innovative thinking focusing multidrug-resistant

Language: Английский

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A colorimetric smartphone-based platform for pesticides detection using Fe-N/C single-atom nanozyme as oxidase mimetics

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 436, P. 129199 - 129199

Published: May 21, 2022

Language: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977

Published: Aug. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Language: Английский

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Dimensionality Engineering of Single-Atom Nanozyme for Efficient Peroxidase-Mimicking

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(30), P. 16835 - 16842

Published: July 24, 2023

In nature, enzymatic reactions occur in well-functioning catalytic pockets, where substrates bind and react by properly arranging the sites amino acids a three-dimensional (3D) space. Single-atom nanozymes (SAzymes) are new type of with active similar to those natural metalloenzymes. However, centers current SAzymes two-dimensional (2D) architectures lack collaborative substrate-binding features limits their activity. Herein, we report dimensionality engineering strategy convert conventional 2D Fe–N-4 into 3D structures integrating oxidized sulfur functionalities onto carbon plane. Our results suggest that could serve as binding for assisting substrate orientation facilitating desorption H2O, resulting an outstanding specific activity up 119.77 U mg–1, which is 6.8 times higher than FeN4C SAzymes. This study paves way rational design highly single-atom nanozymes.

Language: Английский

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Biomedicine meets nanozyme catalytic chemistry

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

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Piezo‐Augmented and Photocatalytic Nanozyme Integrated Microneedles for Antibacterial and Anti‐Inflammatory Combination Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(10)

Published: Dec. 23, 2022

Abstract Wound infection is arguably the most common, and potentially devastating, complication of wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, promote skin formation. Herein, a multifunctional heterostructure designed consisting ultrasmall platinum–ruthenium nanoalloys porous graphitic carbon nitride C 3 N 5 nanosheets (denoted as PtRu/C ), which concurrently possesses piezoelectric enhanced oxidase ‐mimic nanozyme activity photocatalytic hydrogen gas production capacity. Moreover, these hybrid nanotherapeutics are integrated in natural hyaluronic acid microneedles, exhibit almost 100% broad‐spectrum antibacterial efficacy against multiple bacterial strains vitro vivo within 10 min ultrasound treatment, effectively inhibit inflammation reactions after 1 h visible light irradiation, promising for accelerating cutaneous infected mice. This study highlights competitive development all‐in‐one anti‐inflammatory therapies.

Language: Английский

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Emerging antibacterial nanozymes for wound healing

Smart Medicine, Journal Year: 2023, Volume and Issue: 2(3)

Published: Feb. 19, 2023

Abstract Wound infections continuously impose a huge economic and social burden on public healthcare. Despite the effective treatment of bacteria‐infected wounds after using traditional antibiotics, misuse antibiotics usually causes spread bacterial resistance decreases therapeutic outcomes. Therefore, development efficient antibacterial agents is urgently needed. Nanozymes, as new generation artificial enzymes, combine intrinsic abilities nanomaterials natural enzymes. Recently, nanozymes has been widely developed to kill bacteria treat wound by catalyzing various reactive oxygen species. Thus, this concept “antibacterial nanozymes” will promote further advances connecting elimination. To highlight these achievements, we summarize different types for healing. It believed that such promising strategy developing make great contribution in field skin regeneration. We expect play significant roles both basic research clinical applications.

Language: Английский

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