NIR‐II Fluorescence Sensor Based on Steric Hindrance Regulated Molecular Packing for In Vivo Epilepsy Visualization DOI
Mengyao Zhao,

Weiping Lai,

Benhao Li

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(26)

Published: April 19, 2024

Abstract Fluorescence sensing is crucial to studying biological processes and diagnosing diseases, especially in the second near‐infrared (NIR‐II) window with reduced background signals. However, it's still a great challenge construct “off‐on” sensors when wavelength extends into NIR‐II region obtain higher imaging contrast, mainly due difficult synthesis of spectral overlapped quencher. Here, we present new fluorescence quenching strategy, which utilizes steric hindrance quencher (SHQ) tune molecular packing state fluorophores suppress emission signal. Density functional theory (DFT) calculations further reveal that large SHQs can competitively pack prevent their self‐aggregation. Based on this mechanism, novel activatable method achieved via bio‐analyte responsive invalidation SHQ, namely Steric Hindrance Invalidation geNerated Emission (SHINE) strategy. As proof concept, ClO − ‐sensitive SHQ lead bright signal release epileptic mouse hippocampus under skull high photon scattering brain tissue, providing real‐time visualization generation process living mice.

Language: Английский

Immunogenic Cell Death in Hematological Malignancy Therapy DOI Creative Commons
Zhaoyun Liu, Xintong Xu,

Kaining Liu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 23, 2023

Although the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance will eventually recur. Furthermore, microenvironment disorder is an important mechanism pathogenesis malignancies. Immunogenic cell death (ICD) a unique regulated (RCD) that triggers intact antigen-specific adaptive immune response by firing set danger signals damage-associated molecular patterns (DAMPs), which immunotherapeutic modality with potential for treatment This review summarizes existing knowledge about induction ICD and current research on combining inducers other strategies

Language: Английский

Citations

29
Smart One‐for‐All Agent with Adaptive Functions for Improving Photoacoustic /Fluorescence Imaging‐Guided Photodynamic Immunotherapy DOI
Heqi Gao,

Xinwen Qi,

Jingtian Zhang

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Feb. 19, 2023

Multifunctional phototheranostics that integrate several diagnostic and therapeutic strategies into one platform hold great promise for precision medicine. However, it is really difficult molecule to possess multimodality optical imaging therapy properties all functions are in the optimized mode because absorbed photoenergy fixed. Herein, a smart one-for-all nanoagent photophysical energy transformation processes can be facilely tuned by external light stimuli developed precise multifunctional image-guided therapy. A dithienylethene-based designed synthesized has two light-switchable forms. In ring-closed form, most of dissipates via nonradiative thermal deactivation photoacoustic (PA) imaging. ring-open possesses obvious aggregation-induced emission features with excellent fluorescence photodynamic properties. vivo experiments demonstrate preoperative PA help delineate tumors high-contrast manner, intraoperative able sensitively detect tiny residual tumors. Furthermore, induce immunogenic cell death elicit antitumor immunity significantly suppress solid This work develops agent related phototheranostic light-driven structure switch, which promising biomedical applications.

Language: Английский

Citations

27
A Highly Bright Near‐Infrared Afterglow Luminophore for Activatable Ultrasensitive In Vivo Imaging DOI
Yang Li, Min Zhao, Wan Chen

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(4)

Published: Nov. 29, 2023

Afterglow luminescence imaging probes, with long-lived emission after cessation of light excitation, have drawn increasing attention in biomedical field owing to their elimination autofluorescence. However, current afterglow agents always suffer from an unsatisfactory signal intensity and complex systems consisting multiple ingredients. To address these issues, this study reports a near-infrared (NIR) luminophore (TPP-DO) by chemical conjugation substrate photosensitizer acting as both initiator energy relay unit into single molecule, resulting intramolecular transfer process improve the brightness. The constructed TPP-DO NPs emit strong NIR up 10

Language: Английский

Citations

27
Antitumor Effects of a Distinct Sonodynamic Nanosystem through Enhanced Induction of Immunogenic Cell Death and Ferroptosis with Modulation of Tumor Microenvironment DOI Creative Commons
Haitao Yuan, Jingbo Ma, Wei Huang

et al.

JACS Au, Journal Year: 2023, Volume and Issue: 3(5), P. 1507 - 1520

Published: May 9, 2023

Sonodynamic therapy (SDT) holds great promise to be applied for cancer in clinical settings. However, its poor therapeutic efficacy has limited applications owing the apoptosis-resistant mechanism of cells. Moreover, hypoxic and immunosuppressive tumor microenvironment (TME) also weakens immunotherapy solid tumors. Therefore, reversing TME remains a formidable challenge. To circumvent these critical issues, we developed an ultrasound-augmented strategy regulate by utilizing HMME-based liposomal nanosystem (HB liposomes), which can synergistically promote induction ferroptosis/apoptosis/immunogenic cell death (ICD) initiate reprograming TME. The RNA sequencing analysis demonstrated that apoptosis, hypoxia factors, redox-related pathways were modulated during treatment with HB liposomes under ultrasound irradiation. vivo photoacoustic imaging experiment showed enhanced oxygen production TME, alleviated hypoxia, helped overcome tumors, consequently improving SDT efficiency. More importantly, extensively induced ICD, resulting T-cell recruitment infiltration, normalizes facilitates antitumor immune responses. Meanwhile, system combined PD1 checkpoint inhibitor achieves superior synergistic inhibition. Both vitro results indicate act as sonodynamic adjuvant is able induce ferroptosis/apoptosis/ICD via generated lipid-reactive oxide species reprogram due ICD induction. This integrating supply, reactive generation, excellent effective modulation efficient therapy.

Language: Английский

Citations

25
A Self‐Sustaining Near‐Infrared Afterglow Chemiluminophore for High‐Contrast Activatable Imaging DOI

Jieli Zhu,

Wan Chen, Li Yang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(11)

Published: Jan. 22, 2024

Afterglow imaging holds great promise for ultrasensitive bioimaging due to its elimination of autofluorescence. Self-sustaining afterglow molecules (SAMs), which enable all-in-one photon sensitization, chemical defect formation and generation, possess a simplified, reproducible, efficient superiority over commonly used multi-component systems. However, there is lack SAMs, particularly those with much brighter near-infrared (NIR) emission structural flexibility building high-contrast activatable probes. To address these issues, this study the first time reports methylene blue derivative-based self-sustaining agent (SAN-M) NIR chemiluminescence peaking at 710 nm. By leveraging tunability, an nanoprobe (SAN-MO) customized simultaneously fluoro-photoacoustic peroxynitrite (ONOO

Language: Английский

Citations

15
Theranostics - a sure cure for cancer after 100 years? DOI Creative Commons
Yangmeihui Song, Jianhua Zou, Ernesto Castellanos

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2464 - 2488

Published: Jan. 1, 2024

Cancer has remained a formidable challenge in medicine and claimed an enormous number of lives worldwide.Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer.This review aims provide overview theranostics oncology: exploring its history, current advances, challenges, prospects.We present fundamental evolution from radiotherapeutics, cellular therapeutics, nanotherapeutics, showcasing critical milestones last decade.From early concept targeted drug delivery emergence medicine, benefited advances imaging technologies, molecular biology, nanomedicine.Furthermore, we emphasize pertinent illustrations that revolutionary strategies cancer management enhance accuracy therapies customized for individual patients, thereby facilitating implementation medicine.Finally, describe future perspectives on emerging topics, field.

Language: Английский

Citations

15
Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy DOI
Qiang Liu,

Chuyang Sun,

Ruilong Dai

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 503, P. 215652 - 215652

Published: Jan. 9, 2024

Language: Английский

Citations

14
A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors DOI

Chonglu Li,

Le Tu, Yuling Xu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)

Published: May 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Language: Английский

Citations

14
Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging DOI Creative Commons
Yue Jiang, Min Zhao,

Jia Miao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 8, 2024

Abstract Activatable afterglow luminescence nanoprobes enabling switched “off-on” signals in response to biomarkers have recently emerged achieve reduced unspecific and improved imaging fidelity. However, such always use a biomarker-interrupted energy transfer obtain an activatable signal, which necessitates strict distance requisition between donor acceptor moiety (<10 nm) hence induces low efficiency non-feasibility. Herein, we report organic upconversion cocktail nanoparticles (ALCNs) that instead utilize acidity-manipulated singlet oxygen ( 1 O 2 ) with enlarged thus possess more flexibility signal. After vitro validation of acidity-activated luminescence, ALCNs vivo 4T1-xenograft subcutaneous tumors female mice orthotopic liver male high signal-to-noise ratio (SNR). As representative targeting trial, Bio-ALCNs biotin modification prove the enhanced ability, sensitivity, specificity for pulmonary metastasis tumor via systemic administration mice, also implies potential broad utility diverse design flexibility. Therefore, this study provides innovative general approach better performance than fluorescence imaging.

Language: Английский

Citations

13
Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death DOI Creative Commons

Yu‐Qiang Zhao,

Le Yu,

Lanyun Zhang

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 22, 2024

Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.

Language: Английский

Citations

12