Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Immunogenic
cell
death
(ICD)-mediated
immunization
strategies
have
great
potential
against
breast
cancer.
However,
traditional
neglect
the
increase
in
immunosuppressive
metabolite,
adenosine
(ADO),
during
ICD,
leading
to
insufficient
therapeutic
outcomes.
In
this
study,
it
is
found
that
A2A
receptor
(A2AR)
significantly
expressed
cancer
and
positively
associated
with
regulatory
T
(Treg)
cells.
Herein,
a
strategy
combining
Fe/Mo-based
lipid
peroxidation
(LPO)
nanoamplifiers
A2AR
blockade
reported
maximize
ICD-mediated
anti-tumor
immunity.
This
LPO
nanoamplifier
causes
explosion
by
Fe
(II)-mediated
Fenton
reaction
Mo(V)-mediated
Russell
mechanism.
Subsequently,
elicits
ICD
magnification
of
tumor
cells
inducing
multiple
regulated
patterns
ferroptosis,
apoptosis,
necroptosis.
Additionally,
antagonist
(SCH58261),
an
immunometabolic
checkpoint
blocker,
relieve
ADO-related
immunosuppression,
amplify
immunological
effects,
elicit
immune
memory
responses.
robust
immunity
observed
primary,
distant,
pulmonary
metastatic,
recurrent
tumors.
study
provides
novel
for
optimizing
immunotherapy
highlights
benefits
enhance
immunotherapy.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
18(1), P. 713 - 727
Published: Dec. 20, 2023
Porphyrins
and
their
derivatives
are
widely
used
as
photosensitizers
sonosensitizers
in
tumor
treatment.
Nevertheless,
poor
water
solubility
low
chemical
stability
reduce
singlet
oxygen
(1O2)
yield
and,
consequently,
photodynamic
therapy
(PDT)
sonodynamic
(SDT)
efficiency.
Although
strategies
for
porphyrin
molecule
assembly
have
been
developed
to
augment
1O2
generation,
there
is
scope
further
improving
PDT
SDT
efficiencies.
Herein,
we
synthesized
ordered
manganese
(SM)
nanoparticles
with
well-defined
self-assembled
metalloporphyrin
networks
that
enabled
efficient
energy
transfer
enhanced
photocatalytic
sonocatalytic
activity
production.
Subsequently,
Au
were
grown
situ
on
the
SM
surface
by
anchoring
terminal
alkynyl
of
form
plasmonic
SMA
heterostructures,
which
showed
excellent
near-infrared-II
(NIR-II)
region
absorption
photothermal
properties,
facilitated
electron–hole
pair
separation
transfer.
With
modification
hyaluronic
acid
(HA),
SMAH
heterostructure
nanocomposites
exhibited
good
actively
targeted
cancer
cells.
Under
NIR-II
light
ultrasound
(US)
irradiation,
generates
hyperthermia,
a
large
amount
1O2,
inducing
cell
damage.
Both
vitro
vivo
studies
confirmed
effectively
suppressed
growth
decreasing
GSH
levels
SDT-augmented
PDT/PTT.
Moreover,
utilizing
strong
window,
can
achieve
photoacoustic
imaging-guided
combined
This
work
provides
paradigm
enhancing
metalloporphyrins
improve
synergistic
therapeutic
effect
SDT/PDT/PTT.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(15), P. 10495 - 10508
Published: April 1, 2024
Sonodynamic
therapy
(SDT)
has
promising
application
prospects
in
tumor
therapy.
However,
SDT
does
not
eradicate
metastatic
tumors.
Herein,
Cu-substituted
ZnAl
ternary
layered
double
hydroxide
nanosheets
(ZCA
NSs)
were
developed
as
both
sonosensitizers
and
copper
nanocarriers
for
synergistic
SDT/cuproptosis
cancer
An
optimized
electronic
structure
more
conducive
to
the
sonodynamic
process
was
obtained
from
ZCA
NSs
via
Jahn–Teller
effect
induced
by
introduction
of
Cu2+,
synthesized
regulated
intricate
microenvironment
(TME)
depleting
endogenous
glutathione
(GSH)
amplify
oxidative
stress
further
enhanced
performance.
Furthermore,
cuproptosis
evoked
intracellular
overload
Cu2+
amplified
SDT,
leading
irreversible
proteotoxicity.
In
vitro
results
showed
that
such
synergetic
triggered
immunogenic
cell
death
(ICD)
promoted
maturation
dendritic
cells
(DCs).
as-synthesized
NS-mediated
thoroughly
eradicated
vivo
solid
tumors
simultaneously
elicited
antitumor
immunity
suppress
lung
liver
metastasis.
Overall,
this
work
established
a
nanoplatform
with
satisfactory
immunity.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 94 - 114
Published: Aug. 7, 2023
Immunogenic
cell
death
(ICD)
is
a
unique
mode
of
death,
which
can
release
immunogenic
damage-associated
molecular
patterns
(DAMPs)
and
tumor-associated
antigens
to
trigger
long-term
protective
antitumor
immune
responses.
Thus,
amplifying
"eat
me
signal"
during
tumor
ICD
cascade
critical
for
cancer
immunotherapy.
Some
therapies
(radiotherapy,
photodynamic
therapy
(PDT),
photothermal
(PTT),
etc.)
inducers
(chemotherapeutic
agents,
have
enabled
initiate
and/or
facilitate
activate
Recently,
nanostructure-based
drug
delivery
systems
been
synthesized
inducing
through
combining
treatment
chemotherapeutic
photosensitizers
PDT,
transformation
agents
PTT,
radiosensitizers
radiotherapy,
etc.,
loaded
at
an
appropriate
dosage
in
the
designated
place
time,
contributing
higher
efficiency
lower
toxicity.
Also,
immunotherapeutic
combination
with
produce
synergetic
effects,
thus
potentiating
Overall,
our
review
outlines
emerging
inducers,
nanostructure
loading
diverse
evoke
chemoradiotherapy,
PTT
or
agents.
Moreover,
we
discuss
prospects
challenges
harnessing
induction-based
immunotherapy,
highlight
significance
multidisciplinary
interprofessional
collaboration
promote
optimal
translation
this
strategy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(15), P. 10542 - 10556
Published: April 1, 2024
Immunotherapy
has
emerged
as
a
potential
approach
for
breast
cancer
treatment.
However,
the
rigid
stromal
microenvironment
and
low
immunogenicity
of
tumors
strongly
reduce
sensitivity
to
immunotherapy.
To
sensitize
patients
immunotherapy,
hyaluronic
acid-modified
zinc
peroxide–iron
nanocomposites
(Fe-ZnO2@HA,
abbreviated
FZOH)
were
synthesized
remodel
increase
tumor
immunogenicity.
The
constructed
FZOH
spontaneously
generated
highly
oxidative
hydroxyl
radicals
(·OH)
that
degrade
acid
(HA)
in
extracellular
matrix
(ECM),
thereby
reshaping
enhancing
blood
perfusion,
drug
penetration,
immune
cell
infiltration.
Furthermore,
not
only
triggers
pyroptosis
through
activation
caspase-1/GSDMD-dependent
pathway
but
also
induces
ferroptosis
various
mechanisms,
including
increasing
levels
Fe2+
intracellular
iron
pool,
downregulating
expression
FPN1
inhibit
efflux,
activating
p53
signaling
cause
failure
SLC7A11-GSH-GPX4
axis.
Upon
treatment
with
FZOH,
4T1
cells
undergo
both
pyroptosis,
exhibiting
strong
immunogenic
response.
remodeling
response
induced
by
collectively
compensate
limitations
immunotherapy
significantly
enhance
antitumor
checkpoint
inhibitor
αPD-1.
This
study
proposes
perspective
therapy
cancer.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 12830 - 12844
Published: May 6, 2024
The
immunosuppressive
microenvironment
of
cervical
cancer
significantly
hampers
the
effectiveness
immunotherapy.
Herein,
PEGylated
manganese-doped
calcium
sulfide
nanoparticles
(MCSP)
were
developed
to
effectively
enhance
antitumor
immune
response
through
gas-amplified
metalloimmunotherapy
with
dual
activation
pyroptosis
and
STING
pathway.
bioactive
MCSP
exhibited
ability
rapidly
release
Ca2+,
Mn2+,
H2S
in
tumor
microenvironment.
disrupted
buffer
system
cells
by
interfering
oxidative
phosphorylation
pathway,
leading
overload-triggered
pyroptosis.
On
other
hand,
H2S-mediated
mitochondrial
dysfunction
further
promoted
DNA
(mtDNA),
enhancing
effect
Mn2+
on
cGAS-STING
signaling
axis
thereby
activating
immunosuppressed
dendritic
cells.
released
acted
as
an
important
synergist
between
Ca2+
modulating
mechanisms
bridge
innate
adaptive
responses.
combination
NPs
PD-1
immunotherapy
achieved
synergistic
effects
inhibited
growth.
This
study
reveals
potential
collaboration
gas
therapy
provides
idea
for
design
nanoimmunomodulators
rational
regulation
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(18)
Published: Feb. 7, 2024
Sonodynamic
therapy
(SDT)
has
garnered
growing
interest
owing
to
its
high
tissue
penetration
depth
and
minimal
side
effects.
However,
the
lack
of
efficient
sonosensitizers
remains
primary
limiting
factor
for
clinical
application
this
treatment
method.
Here,
defect-repaired
graphene
phase
carbon
nitride
(g-C
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(13)
Published: Jan. 22, 2024
Abstract
Although
immunogenic
cell
death
(ICD)
inducers
evidently
enhance
the
effectiveness
of
immunotherapy,
their
potential
is
increasingly
restricted
by
development
apoptosis
resistance
in
tumor
cells,
poor
immunogenicity,
and
low
T‐cell
immune
responsiveness.
In
this
study,
for
first
time,
piezoelectrically
catalyzed
Mg
2+
‐doped
hydroxyapatite
(Mg‐HAP)
nanoparticles,
which
are
coated
with
a
mesoporous
silica
layer
loaded
ONC201
as
an
agonist
to
specifically
target
receptor
DR5
on
ultimately
developing
Mg‐HAP@MS/ONC201
nanoparticle
(MHMO
NP)
system,
engineered.
Owing
its
excellent
piezoelectric
properties,
MHMO
facilitates
release
significant
amount
reactive
oxygen
species
Ca
within
effectively
promoting
upregulation
expression
inducing
necroptosis
overcome
resistance.
Concurrently,
released
microenvironment
promotes
CD8
+
T
activation
response
antitumor
reaction
induced
ICD.
Using
RNA‐seq
analysis,
it
elucidated
that
can
activate
NF‐κB
pathway
under
catalysis,
thus
M1‐type
macrophage
polarization.
summary,
dual‐targeting
therapy
system
targets
both
cells
catalysis
designed.
This
holds
substantial
advancements
immunotherapy.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(7), P. 3224 - 3252
Published: Jan. 1, 2024
Neoantigens
play
a
pivotal
role
in
the
field
of
tumour
therapy,
encompassing
stimulation
anti-tumour
immune
response
and
enhancement
targeting
capability.
Nonetheless,
numerous
factors
directly
influence
effectiveness
neoantigens
bolstering
responses,
including
neoantigen
quantity
specificity,
uptake
rates
by
antigen-presenting
cells
(APCs),
residence
duration
within
microenvironment
(TME),
their
ability
to
facilitate
maturation
APCs
for
activation.
Nanotechnology
assumes
significant
several
aspects,
facilitating
release,
promoting
delivery
cells,
augmenting
dendritic
shielding
from
protease
degradation,
optimizing
interactions
between
system.
Consequently,
development
nanotechnology
synergistically
enhances
efficacy
cancer
theranostics.
In
this
review,
we
provide
an
overview
sources,
mechanisms
neoantigen-induced
evolution
precision
neoantigen-based
nanomedicine.
This
encompasses
various
therapeutic
modalities,
such
as
immunotherapy,
phototherapy,
radiotherapy,
chemotherapy,
chemodynamic
other
strategies
tailored
augment
therapeutics.
We
also
discuss
current
challenges
prospects
application
nanomedicine,
aiming
expedite
its
clinical
translation.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 24, 2025
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
modality
for
malignant
tumors
mainly
involves
in
sonosensitizers
and
low-intensity
ultrasound
(US),
which
can
safely
penetrate
the
tissue
without
significant
attenuation.
SDT
not
only
has
advantages
including
high
precision,
non-invasiveness,
minimal
side
effects,
but
also
overcomes
limitation
of
low
penetration
light
to
deep
tumors.
The
cytotoxic
reactive
oxygen
species
be
produced
by
utilization
combined
with
US
kill
tumor
cells.
However,
underlying
mechanism
been
elucidated,
its
unsatisfactory
efficiency
retards
further
clinical
application.
Herein,
we
shed
on
main
mechanisms
types
sonosensitizers,
organic
inorganic
sonosensitizers.
Due
development
nanotechnology,
many
novel
nanoplatforms
are
utilized
this
arisen
field
solve
barriers
enable
continuous
innovation.
This
review
highlights
potential
nanosonosensitizers
focus
enhanced
based
monotherapy
or
synergistic
that
difficult
reach
traditional
treatment,
especially
orthotopic
cancers.