Engineering Nanozymes for Tumor Therapy via Ferroptosis Self‐Amplification DOI

Shuyu Liu,

Wei Yi,

Yuan Liang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 4, 2024

Ferroptosis induction is an emerging strategy for tumor therapy. Reactive oxygen species (ROS) can induce ferroptosis but are easily consumed by overexpressed glutathione (GSH) in cells. Therefore, achieving a large amount of ROS production cells without being key to efficiently inducing ferroptosis. In this study, self-amplifying ferroptosis-inducing therapeutic agent, Pd@CeO

Language: Английский

Polydopamine Nanostructure-Enhanced Water Interaction with pH-Responsive Manganese Sulfide Nanoclusters for Tumor Magnetic Resonance Contrast Enhancement and Synergistic Ferroptosis–Photothermal Therapy DOI

Guiqi Ma,

Xinyu Zhang,

Kunlong Zhao

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3369 - 3381

Published: Jan. 22, 2024

Rational structure design benefits the development of efficient nanoplatforms for tumor theranostic application. In this work, a multifunctional polydopamine (PDA)-coated manganese sulfide (MnS) nanocluster was prepared. The polyhydroxy PDA enhanced water interaction with pH-responsive MnS nanoclusters via hydrogen bonds. At pH 5.5 conditions, spin–lattice relaxation rate dramatically increased from 5.76 to 19.33 mM–1·s–1 after coating, which can be beneficial magnetic resonance imaging. addition, endowed excellent biocompatibility and good photothermal conversion efficiency, used therapy (PTT). Furthermore, possess ability release H2S in acidic microenvironment, effectively inhibiting mitochondrial respiration adenosine triphosphate production. As result, expression heat shock protein obviously reduced, reduce resistance cells stimulation enhance efficacy PTT. released Mn2+ also displayed peroxidase glutathione oxidase-like activity, inducing cell ferroptosis apoptosis at same time. Therefore, nanoplatform could potential nanotheranostic contrast enhancement synergistic ferroptosis–PTT tumors.

Language: Английский

Citations

41
A strategy of “adding fuel to the flames” enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy DOI
Lin Huang,

Jiaoyang Zhu,

Guochao Wu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122701 - 122701

Published: July 6, 2024

Language: Английский

Citations

21
pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy DOI Creative Commons
Jianhua Zou, Zheng Li, Yang Zhu

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 414 - 421

Published: Jan. 10, 2024

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive tumor microenvironment (TME) enhance PDT through glutathione (GSH) depletion. Our approach aims expand sources therapeutic benefits by promoting generation superoxide radicals (O

Language: Английский

Citations

19
Dual‐Active Center AgFeCu Nanocatalyst for Tumor Destruction via Self‐Catalytically Enhanced Mild Photothermal Therapy DOI Open Access

Xuegang Niu,

Yang Zhu, Chenyu Ding

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(51)

Published: Aug. 17, 2023

Abstract Mild photothermal therapy (mPTT) has emerged as a highly promising approach for tumor ablation. However, the heat‐induced overexpression of heat shock proteins (HSPs) limits its efficacy by increasing cellular temperature tolerance. Herein, self‐catalytically enhanced mild PTT strategy that directly disrupts structure HSPs to restore cell sensitivity is proposed. In proof‐of‐concept study, AgFeCu nanoparticles (AgFeCu NPs) with dual‐active catalytic centers (Fe‐Cu) and near‐infrared properties are developed. The NPs can efficiently catalyze conversion endogenous hydrogen peroxide into hydroxyl radicals in situ, leading degradation enhancing therapeutic effects mediated their Ag‐based substrates. Furthermore, also induce oxidative stress depleting intracellular glutathione promoting lipid peroxidation, thereby triggering ferroptosis resulting significant elimination U87MG murine model. This maximizes while minimizing damage healthy tissues, which expected provide valuable insights development next‐generation nanoagents improved therapeutics.

Language: Английский

Citations

34
Nanomaterial‐Enabled Photothermal Heating and Its Use for Cancer Therapy via Localized Hyperthermia DOI Open Access
Song Shen, Jichuan Qiu, Da Huo

et al.

Small, Journal Year: 2023, Volume and Issue: 20(7)

Published: Oct. 6, 2023

Abstract Photothermal therapy (PTT), which employs nanoscale transducers delivered into a tumor to locally generate heat upon irradiation with near‐infrared light, shows great potential in killing cancer cells through hyperthermia. The efficacy of such treatment is determined by number factors, including the amount, distribution, and dissipation generated heat, as well type cell involved. amount largely controlled accumulated inside tumor, absorption coefficient photothermal conversion efficiency transducer, irradiance light. depends on distribution penetration depth vascularity tissue thermal conduction both affect thereby temperature. successful implementation PTT clinic setting critically techniques for real‐time monitoring management

Language: Английский

Citations

27
Smart Lipid Nanoparticle that Remodels Tumor Microenvironment for Activatable H2S Gas and Photodynamic Immunotherapy DOI
Luyan Wu, Yili Liu, Wenhui Zeng

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(50), P. 27838 - 27849

Published: Dec. 7, 2023

Hydrogen sulfide (H2S) has shown promise for gas therapy. However, it is still controversial whether H2S can remodel the tumor microenvironment (TME) and induce robust antitumor immunity. Here, a tumor-targeting TME-responsive "smart" lipid nanoparticle (1-JK-PS-FA) presented, which capable of delivering releasing specifically in tissues on-demand photodynamic immunotherapy. 1-JK-PS-FA enables burst release acidic TME, promptly reduces embedded organic electrochromic materials consequently switches on near-infrared fluorescence activity. Furthermore, we found that high levels reprogram TME by reducing interstitial fluid pressure, promoting angiogenesis, increasing vascular permeability, ameliorating hypoxia, immunosuppressive conditions. This leads to increased uptake 1-JK-PS-FA, thereby enhancing PDT efficacy eliciting strong immunogenic cell death during 808 nm laser irradiation. Therefore, permits synergistic immunotherapy, effectively eradicating orthotopic breast tumors preventing metastasis recurrence. work showcases capacity enhance

Language: Английский

Citations

23
An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death DOI Creative Commons
Tao Feng, Zixin Tang, Johannes Karges

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(18), P. 6752 - 6762

Published: Jan. 1, 2024

A mitochondria-localizing iridium( iii ) photosensitizer produces singlet oxygen and superoxide anion radicals upon two-photon irradiation, disrupting the mitochondrial respiratory chain inducing ferritinophagy immunogenic cell death.

Language: Английский

Citations

15
Theranostics - a sure cure for cancer after 100 years? DOI Creative Commons
Yangmeihui Song, Jianhua Zou, Ernesto Castellanos

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2464 - 2488

Published: Jan. 1, 2024

Cancer has remained a formidable challenge in medicine and claimed an enormous number of lives worldwide.Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer.This review aims provide overview theranostics oncology: exploring its history, current advances, challenges, prospects.We present fundamental evolution from radiotherapeutics, cellular therapeutics, nanotherapeutics, showcasing critical milestones last decade.From early concept targeted drug delivery emergence medicine, benefited advances imaging technologies, molecular biology, nanomedicine.Furthermore, we emphasize pertinent illustrations that revolutionary strategies cancer management enhance accuracy therapies customized for individual patients, thereby facilitating implementation medicine.Finally, describe future perspectives on emerging topics, field.

Language: Английский

Citations

15
Boosting Energy Deprivation by Synchronous Interventions of Glycolysis and Oxidative Phosphorylation for Bioenergetic Therapy Synergetic with Chemodynamic/Photothermal Therapy DOI Creative Commons

Xiangjun Wei,

Renlu Han,

Yun Gao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)

Published: March 15, 2024

Abstract Bioenergetic therapy is emerging as a promising therapeutic approach. However, its effectiveness restricted by metabolic plasticity, tumor cells switch phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) BAY‐876 (BAY) co‐loaded CuFe 2 O 4 (CF) nanoplatform (CFMB) developed boost energy deprivation synchronous interventions of OXPHOS bioenergetic synergetic with chemodynamic/photothermal (CDT/PTT). The MET can simultaneously restrain inhibiting hexokinase (HK2) activity damaging mitochondrial function deprive energy, respectively. Besides, BAY blocks glucose uptake transporter 1 (GLUT1) expression, further potentiating the repression thus achieving much more depletion tumorigenic sources. Interestingly, upregulated antioxidant glutathione (GSH) in cancer triggers CFMB degradation release Cu + /Fe 2+ catalyzing tumor‐overexpressed H hydroxyl radical (∙OH), both impairing GSH‐depletion amplified CDT. Furthermore, upon near‐infrared (NIR) light irradiation, has photothermal conversion capacity kill PTT improve ∙OH production enhanced In vivo experiments have manifested that remarkably suppressed growth mice without systemic toxicity. This study provides new modality paradigm bioenergetic‐related therapies.

Language: Английский

Citations

14
A Bioinspired Photosensitizer Performs Tumor Thermoresistance Reversion to Optimize the Atraumatic Mild‐Hyperthermia Photothermal Therapy for Breast Cancer DOI
Jie Li,

Die Yang,

Wentao Lyu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 24, 2024

Abstract Mild‐hyperthermia photothermal therapy (mPTT) has therapeutic potential with minimized damage to normal tissues. However, the poorly vascularized tumor area severely hampers penetration of agents (PTAs), resulting in their heterogeneous distribution and subsequent local temperature during mPTT. The presence regions below 42 °C threshold can lead incomplete ablation recurrence. Additionally, anti‐apoptosis cytoprotection pathways, particularly activated thermoresistance, nullify mild hyperthermia‐induced damage. Therefore, a bioinspired photosensitizer decorated leucine form biomimetic nanoclusters (CP‐PLeu nanoparticles (NPs)) aimed at achieving rapid homogeneous accumulation tumors, is introduced. Moreover, CP‐PLeu exhibits photodynamic effects that reverse thermoresistance physiological repair mechanisms, thereby inhibiting resistance hyperthermia. With addition NIR‐II laser irradiation, optimizes efficacy mPTT contributes minimally invasive process for breast cancer. This strategy, utilizing photoactivated reversal successfully achieves efficient inhibition through an atraumatic process.

Language: Английский

Citations

13