International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135180 - 135180
Published: Aug. 29, 2024
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 4(2)
Published: Oct. 17, 2023
Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.
Language: Английский
Citations
53
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 27, 2024
Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.
Language: Английский
Citations
47
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19
Published: Feb. 7, 2024
Language: Английский
Citations
36
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use inhalation therapies. The effectiveness of NO-based treatments relies on precise control NO concentrations tailored to specific therapeutic needs. Electrochemical generation (E-NOgen) via nitrite (NO2 -) reduction offers a scalable efficient route controlled production, while also addressing environmental concerns by reducing NO2 - pollution maintaining nitrogen cycle balance. Recent developments catalysts E-NOgen devices have propelled conversion, enabling on-demand production. This review provides overview pathways, with focus cutting-edge Fe/Cu-based catalysts, explores the development biomedical use. Challenges future directions advancing technologies are discussed.
Language: Английский
Citations
2
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147645 - 147645
Published: Nov. 24, 2023
Language: Английский
Citations
27
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)
Published: May 1, 2024
Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease
Language: Английский
Citations
13
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205
Published: Sept. 11, 2024
Language: Английский
Citations
13
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 30, 2024
The main issues faced during the treatment of apical periodontitis are management bacterial infection and facilitation repair alveolar bone defects to shorten disease duration. Conventional root canal irrigants limited in their efficacy associated with several side effects. This study introduces a synergistic therapy based on nitric oxide (NO) antimicrobial photodynamic (aPDT) for periodontitis.
Language: Английский
Citations
12
npj Flexible Electronics, Journal Year: 2024, Volume and Issue: 8(1)
Published: May 11, 2024
Abstract Wound infection is a worldwide health issue that not only brings large detrimental effects to people’s physical and mental health, but also causes substantial economic burdens society. By using traditional surgical debridement antibiotic therapy, patients generally suffer more pain are at risk of recurring infections. Thus, the development non-antibiotic treatment methods desperately needed. Currently, emerging flexible wound dressings with physiological signal detection, inactivated infectious pathogen, wound-healing promoting properties has exhibited immense potential for infected wound. Among various dressings, MXene‐based electronic materials as special electroactive, mechanical, photophysical, biological performances possess broad application prospect in healthcare. In this review, challenges management introduced. Next, types MXene-based features outlined. Then recent advance detection summarized. Lastly, predicaments, prospects, future directions discussed.
Language: Английский
Citations
12
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)
Published: Aug. 22, 2024
The prevalence of drug-resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one the foremost challenges in medical care. Thus, there is an urgent imperative develop safe efficacious novel antimicrobial strategies. Nitric oxide (NO) recognized endogenous signaling molecule, which plays pivotal role numerous pathological processes. Currently, NO garnered significant interest antibacterial agent due its capability eradicate bacteria, disrupt biofilms, facilitate wound healing, all while circumventing emergence drug resistance. However, inherently unstable characteristic therapeutic gas renders controlled administration gases exceedingly challenging. Hence, this review, current challenge infection discussed; then it briefly elucidated mechanism comprehensively delineate recent advancements stimulus-responsive delivery platforms, along with their merits, obstacles, prospective avenues for application. This review offers guidance future NO-medicated anti-infection therapy hoped.
Language: Английский
Citations
8