Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394

Published: June 11, 2024

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.

Language: Английский

---

Activating Macrophage Continual Efferocytosis via Microenvironment Biomimetic Short Fibers for Reversing Inflammation in Bone Repair

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 6, 2024

Abstract Efferocytosis‐mediated inflammatory reversal plays a crucial role in bone repairing process. However, refractory defects, the macrophage continual efferocytosis may be suppressed due to disrupted microenvironment homeostasis, particularly loss of apoptotic signals and overactivation intracellular oxidative stress. In this study, polydopamine‐coated short fiber matrix containing biomimetic “apoptotic signals” reconstruct reactivate for defect repair is presented. The (AM/CeO 2 ) are prepared using CeO nanoenzymes with neutrophil membrane coating recognition stress regulation. Additionally, “biomimetic matrix” utilized loading AM/CeO via abundant adhesion sites involving π – stacking hydrogen bonding interactions. Ultimately, implantable apoptosis‐mimetic nanoenzyme/short‐fiber matrixes (PFS@AM/CeO ), integrating matrixes, constructed facilitate reestablish pro‐efferocytosis microenvironment. vitro vivo data indicate that fibers can activate efferocytosis, leading suppression overactivated inflammation. enhanced rat femoral further demonstrates osteogenic potential strategy. It believed regulation through materials provide new perspective tissue repair.

Language: Английский

---

Responsive Zwitterionic Materials for Enhanced Drug Delivery

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Zwitterionic materials have traditionally been recognized as exceptional antifouling agents, imparting nanocarriers with extended circulation times in vivo. Despite much studies on ability, the responsive zwitterionic that change physicochemical properties stimulated by mild signals are less explored. As is known, there multiple biological barriers antitumor drug delivery, including blood barrier, non-specific organ distribution, elevated tumor interstitial pressure, cytomembrane and lysosomal barrier. Multiple restrict delivery efficiency of to tumors, leading a reduced therapeutic effect increased side effects. Therefore, it far from satisfactory overcome barrier alone for classical materials. To address this challenge, recently developed engineered barriers, thereby enabling more effective delivery. Furthermore, could respond themselves without need incorporating extra stimuli-responsive groups, which maintains simplicity molecular structure. In mini-review, recent progress responding pH, temperature, enzyme, or reactive oxygen species summarized. prospects challenges provided promote better development field.

Language: Английский

---

In Situ Dual-targeted Drug Delivery System for Alleviating Imaging and Pathological Damage in Septic Arthritis

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Gold Nanoparticles Modulate Macrophage Polarization to Promote Skeletal Muscle Regeneration

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101653 - 101653

Published: March 12, 2025

Skeletal muscle regeneration is a complex process that depends on the interplay between immune responses and stem cell (MuSC) activity. Macrophages play crucial role in this process, exhibiting distinct polarization states-M1 (pro-inflammatory) M2 (anti-inflammatory)-that significantly affect tissue repair outcomes. Recent advancements nanomedicine have positioned gold nanoparticles (Au NPs) as promising tools for modulating macrophage enhancing regeneration. This review examines of Au NPs influencing behavior, focusing their physicochemical properties, biocompatibility, mechanisms action. We discuss how can promote polarization, facilitating through modulation cytokine production, interaction with surface receptors, activation intracellular signaling pathways. Additionally, we highlight benefits MuSC function, angiogenesis, extracellular matrix remodeling. Despite potential skeletal regeneration, challenges remain optimizing nanoparticle design, developing targeted delivery systems, understanding long-term effects. Future directions should focus personalized medicine approaches combination therapies to enhance therapeutic efficacy. Ultimately, emphasizes transformative regenerative medicine, offering hope improved treatments injuries diseases.

Language: Английский

---

Nanomanaging Chronic Wounds with Targeted Exosome Therapeutics

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 366 - 366

Published: March 13, 2025

Chronic wounds pose a significant healthcare challenge, impacting millions of patients worldwide and burdening systems substantially. These often occur as comorbidities are prone to infections. Such infections hinder the healing process, complicating clinical management proving recalcitrant therapy. The environment within wound itself poses challenges such lack oxygen, restricted blood flow, oxidative stress, ongoing inflammation, bacterial presence. Traditional systemic treatment for chronic peripheral may not be effective due inadequate supply, resulting in unintended side effects. Furthermore, topical applications impervious persistent biofilm A growing concern is therapeutic modalities treating wounds. Additionally, chemically harsh microenvironment can reduce effectiveness treatments, highlighting need drug delivery that deliver therapies precisely where needed with optimal dosages. Compared cell-based therapies, exosome-based offer distinct advantages cell-free approach treatment. Exosomes endosomal origin enable cell-to-cell communications, they possess benefits, including biocompatibility decreased immunogenicity, making them ideal vehicles efficient targeting minimizing off-target damage. However, exosomes rapidly cleared from body, it difficult maintain concentrations at sites. hydrogel-based development biocompatible scaffolds beneficial sustained release prolong presence these Engineered have been shown stability promoting compared their unmodified counterparts. Significant progress has made this field, but further research essential unlock potential. This review seeks explore benefits opportunities wounds, ensuring efficacy precise despite obstacles posed by environment.

Language: Английский

---

Recent Advances of Emerging Spleen‐Targeting Nanovaccines for Immunotherapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: June 8, 2023

Abstract Vaccines provide a powerful tool to modulate the immune system for human disease prevention and treatment. Classical vaccines mainly initiate responses in lymph nodes (LNs) after subcutaneous injection. However, some suffer from inefficient delivery of antigens LNs, undesired inflammation, slow induction when encountering rapid proliferation tumors. Alternatively, spleen, as largest secondary lymphoid organ with high density antigen‐presenting cells (APCs) lymphocytes, acts an emerging target vaccinations body. Upon intravenous administration, rationally designed spleen‐targeting nanovaccines can be internalized by APCs spleen induce selective antigen presentation T B their specific sub‐regions, thereby rapidly boosting durable cellular humoral immunity. Herein, recent advances immunotherapy based on anatomical architectures functional zones well limitations perspectives clinical applications are systematically summarized. The aim is emphasize design innovative enhanced intractable diseases future.

Language: Английский

---

Targeted protein delivery based on stimuli‐triggered nanomedicine

Exploration, Journal Year: 2023, Volume and Issue: 4(3)

Published: Nov. 23, 2023

Abstract Protein‐based drugs have shown unique advantages to treat various diseases in recent years. However, most protein therapeutics clinical use are limited extracellular targets with low delivery efficiency. To realize targeted delivery, a series of stimuli‐triggered nanoparticle formulations been developed improve efficiency and reduce off‐target release. These smart nanoparticles designed release cargo proteins response either internal or external stimuli at pathological tissues. In this way, varieties protein‐based including antibodies, enzymes, pro‐apoptotic can be effectively delivered desired sites for the treatment cancer, inflammation, metabolic diseases, so on minimal side effects. review, advances design nanomedicine different biomedical applications will discussed. A deeper understanding these emerging strategies helps develop more efficient systems future.

Language: Английский

---

Cell Membrane Camouflaged Biomimetic Nanoparticles as a Versatile Platform for Brain Diseases Treatment

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 10, 2024

Abstract Although there are various advancements in biomedical the past few decades, still challenges treatment of brain diseases. The main difficulties inability to deliver a therapeutic dose drug through blood‐brain barrier (BBB) and serious side effects drug. Thus, it is essential select biocompatible carriers novel tools better enhance effect disease treatment. In recent years, biomimetic nanoparticles (BNPs) based on natural cell membranes, which have excellent biocompatibility low immunogenicity, widely used diseases enable successfully cross BBB target lesions. BNPs can prolong circulation time vivo, more conducive aggregation Cell membranes (CMs) from cancer cells (CCs), red blood (RBCs), white (WBCs), so as coatings for (NPs) achieve ability target, evade clearance, or stimulate immune system. This review summarizes application different sources discusses possibilities clinical translation.

Language: Английский

---

Solid Lipid Nanoparticles for Pulmonary Delivery of Biopharmaceuticals: A Review of Opportunities, Challenges, and Delivery Applications

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(7), P. 3084 - 3102

Published: June 3, 2024

Biopharmaceuticals such as nucleic acids, proteins, and peptides constitute a new array of treatment modalities for chronic ailments. Invasive routes remain the mainstay administering biopharmaceuticals due to their labile nature in biological environment. However, it is not preferred long-term therapy lack patient adherence clinical suitability. Therefore, alternative administration are sought utilize novel biopharmaceutical therapies utmost potential. Nanoparticle-mediated pulmonary delivery biologics can facilitate both local systemic disorders. Solid lipid nanoparticles (SLNs) afford many opportunities carriers physicochemical stability ability incorporate hydrophilic hydrophobic moieties, thus allowing combinatorial drug/gene therapies. These applications include infections, lung cancer, cystic fibrosis, while biomolecules, like insulin, also attractive This Review explores physiological particle-associated factors affecting biopharmaceuticals. It compares advantages limitations SLNs nanocarriers along with design improvements underway overcome these limitations. Current research illustrating various SLN designs deliver peptides, plasmids, oligonucleotides, siRNA, mRNA summarized.

Language: Английский

---