Nano formulation approaches for curcumin delivery- a review

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104326 - 104326

Published: March 1, 2023

Language: Английский

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Potential of Curcumin in the Management of Skin Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3617 - 3617

Published: March 23, 2024

Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal preventing treating skin inflammation, premature ageing, psoriasis, acne. Additionally, exhibits antiviral, antimutagenic, antifungal effects. provides protection against damage caused by prolonged exposure UVB radiation. It reduces wound healing times improves collagen deposition. Moreover, increases fibroblast vascular density in wounds. review summarizes available information on therapeutic effect curcumin diseases. The results suggest that may be an inexpensive, well-tolerated, effective agent However, larger clinical trials are needed confirm these observations limitations vivo use, such as low bioavailability after oral administration metabolism.

Language: Английский

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The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 151 - 151

Published: Jan. 20, 2025

Quercetin, a flavonoid found in vegetables and fruits, has been extensively studied for its health benefits disease management. Its role the prevention of various pathogenesis well-documented, primarily through ability to inhibit oxidative stress, inflammation, enhance endogenous antioxidant defense mechanisms. Electronic databases such as Google Scholar, Scopus, PubMed, Medline, Web Science were searched information regarding quercetin pathogeneses. The included literature comprised experimental studies, randomized controlled trials, epidemiological studies related quercetin, while editorials, case analyses, theses, letters excluded. It reported have wide range including hepatoprotective, antidiabetic, anti-obesity, neuroprotective, cardioprotective, wound healing, antimicrobial, immunomodulatory effects, achieved modulation biological activities. Additionally, numerous vitro vivo shown that quercetin’s efficacies cancer management involve inhibiting cell signaling pathways, cycle, angiogenesis, activating pathways tumor suppressor genes, inducing apoptosis. This review aims provide comprehensive understanding this outlines sources nanoformulations, applications management, along with key findings from important clinical trial studies. Limited data safety mechanism action are available. is conduct more trials gain deeper disease-preventive potential, mechanisms action, safety, optimal therapeutic dosages. Furthermore, research based on nanoformulations should be performed minimize/overcome hindrance associated bioavailability, rapid degradation, toxicity.

Language: Английский

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Multifunctional Chitosan/Polycaprolactone Nanofiber Scaffolds with Varied Dual-Drug Release for Wound-Healing Applications

ACS Biomaterials Science & Engineering, Journal Year: 2020, Volume and Issue: 6(8), P. 4666 - 4676

Published: July 6, 2020

Electrospinning-based wound dressings with multifunctional properties, including hemostasis-promoting, antibacterial, drug release, and therapeutic effects, are of great interest in military civilian trauma healthcare. Herein, we designed lidocaine hydrochloride (LID) mupirocin-loaded chitosan/polycaprolactone (CSLD-PCLM) scaffolds multiple functions as dressings. Through the dual spinneret electrospinning technique, achieved a nanofiber structure, which enhanced interfacial interaction between scaffold blood cells showed excellent coagulation capacity. In particular, loaded LID mupirocin exhibited rapid release sustained mupirocin. The CSLD-PCLM containing outstanding antibacterial activity. Moreover, significantly healing process complete re-epithelialization well collagen deposition full-thickness skin defect model. Thus, nanofibrous may ideally meet various requirements promising candidates for future clinical applications.

Language: Английский

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Microfluidic Generation of Nanomaterials for Biomedical Applications

Small, Journal Year: 2019, Volume and Issue: 16(9)

Published: July 1, 2019

As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they becoming one of the most desirable components in fields drug delivery, biosensing, bioimaging, tissue engineering. By choosing an appropriate methodology allows for accurate control over reaction conditions, not only can NMs with high quality rapid production rate be generated, but also designing composite efficient products therapy diagnosis nanomedicine realized. Recent evidence implies microfluidic technology offers a promising platform synthesis by easy manipulation fluids microscale channels. In this Review, comprehensive set developments field microfluidics generating two main classes NMs, including nanoparticles nanofibers, various potentials biomedical applications summarized. Furthermore, major challenges area opinions on its future proposed.

Language: Английский

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Nanofibrous asymmetric collagen/curcumin membrane containing aspirin-loaded PLGA nanoparticles for guided bone regeneration

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Oct. 23, 2020

Abstract The goal of the current study was to develop an asymmetric guided bone regeneration (GBR) membrane benefiting from curcumin and aspirin. prepared using electrospinning technique then physic-chemically characterized by conventional methods. release profile aspirin also measured ultraviolet spectrophotometry. Also, antibacterial activities evaluated. We assessed in vitro effects on biocompatibility osteogenic differentiation dental pulp stem cells (DPSCs), evaluated vivo defects created both sides dog’s jaw histology. results characterization specified that successfully with monodispersed nanosized fibers, uniform network shaped morphology, negative surface charge sustained platform for showed antimicrobial against all tested bacteria. presence enhanced potential at transcriptional translational levels. animal test area completely filled new after just 28 days, while commercial remained empty. There a soft tissue layer above side. suggested this work could be used as GBR keep occupying surgeries. Besides, surgeries can benefited healing novel while, simultaneously, promoting regeneration.

Language: Английский

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Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material

Carbohydrate Polymers, Journal Year: 2020, Volume and Issue: 238, P. 116195 - 116195

Published: March 19, 2020

Language: Английский

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Preparation and characterization of polylactic acid/fenugreek essential oil/curcumin composite films for food packaging applications

International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 194, P. 470 - 483

Published: Nov. 17, 2021

Language: Английский

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Synthesis of nano-fibers containing nano-curcumin in zein corn protein and its physicochemical and biological characteristics

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Jan. 21, 2021

Abstract Curcumin contains many biological activities as a natural bioactive substance, however, its low solubility stands huge bioavailability disadvantage. Recently, different methods have been developed for utilizing the tremendous medicinal properties of this material. In study, an Oil/Water nano-emulsion curcumin (Nano-CUR) has woven in zein polymer at three percentages 5%, 10%, and 15% (v/v). We investigated physicochemical nanofibers (NFs) including FESEM, FTIR, tensile strength, encapsulation efficiency, release profile, well properties. According to data, NFs observed become significantly thinner more uniformed involved percentage Nano-CUR had increased from 5 15%. It is considerable that strength can be by heightening existing 5% towards The resultant zein/Nano-CUR exhibited higher vitro lower efficiency than other evaluated NFs. confirmed through performed viability antioxidant studies 10% are capable providing best conditions cell proliferation. Considering mentioned facts, work suggested successfully maintain their

Language: Английский

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In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Journal of Biomedical Materials Research Part A, Journal Year: 2021, Volume and Issue: 110(2), P. 443 - 461

Published: Aug. 13, 2021

Abstract The skin is one of the most essential tissues in human body, interacting with outside environment and shielding body from diseases excessive water loss. Hydrogels, decellularized porcine dermal matrix, lyophilized polymer scaffolds have all been used studies wound repair, dressing, tissue engineering, however, these materials cannot replicate nanofibrous architecture skin's native extracellular matrix (ECM). Electrospun nanofibers are a fascinating new form nanomaterials tremendous potential across broad spectrum applications biomedical field, including dressings, healing scaffolds, regenerative medicine, bioengineering tissue, multifaceted drug delivery. This article reviews recent vitro vivo developments multifunctional electrospun (MENs) for healing. review begins an introduction to electrospinning process, its principle, processing parameters which significant impact on nanofiber properties. It then discusses various geometries advantages MEN produced by different innovative techniques when combination stem cells. also some possible future nanofiber‐based models that could be used. Finally, we conclude perspectives conclusions this area.

Language: Английский

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