ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(15), P. 18400 - 18410
Published: April 5, 2024
Drug-resistant
bacterial
infection
and
biofilm
formation
are
the
key
inhibitors
of
wound
healing,
new
strategies
urgently
needed
to
address
these
issues.
In
this
study,
we
designed
a
pH-responsive
co-assembled
peptide
hydrogel
inhibit
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
promote
healing.
We
synthesized
cationic
short
(Nap-FFKKK)
with
curcumin
at
pH
∼
7.8.
The
loaded
was
continuously
released
in
weak
acid
environment
(pH
5.5).
lysine-rich
inhibited
MRSA
via
electrostatic
interaction
negatively
charged
cell
surface
and,
thus,
provided
reinforcing
antibacterial
effect
curcumin.
vitro
experiments
showed
that
system
considerably
reduced
minimum
inhibitory
concentration
against
by
10-fold
promoted
healing
mouse
model
MRSA-infected
wounds.
This
study
provides
simple
promising
strategy
treat
drug-resistant
infections
Poultry Science,
Journal Year:
2022,
Volume and Issue:
101(4), P. 101696 - 101696
Published: Jan. 8, 2022
The
poultry
industry
contributes
significantly
to
bridging
the
nutritional
gap
in
many
countries
because
of
its
meat
and
eggs
products
rich
protein
valuable
nutrients
at
a
cost
less
than
other
animal
sources.
natural
antibiotics
alternatives
including
probiotics,
prebiotics,
symbiotics,
organic
acids,
essential
oils,
enzymes,
immunostimulants,
phytogenic
(phytobiotic)
herbs,
botanicals,
oleoresins
are
most
common
feed
additives
that
acquire
popularity
following
ban
antibiotic
growth
promoters
(AGPs).
They
commonly
used
worldwide
their
unique
properties
positive
impact
on
production.
can
be
easily
mixed
with
ingredients,
have
no
tissue
residues,
improve
intake,
gain,
conversion
rate,
bird
immunity,
digestion,
increase
availability
as
well
absorbability,
antimicrobial
effects,
do
not
affect
carcass
characters,
decrease
usage
antibiotics,
acts
antioxidants,
anti-inflammatory,
compete
for
stress
factors
provide
healthy
human
consumption.
Therefore,
current
review
focuses
comprehensive
description
different
promoters'
alternatives,
mode
action,
impacts
Poultry Science,
Journal Year:
2021,
Volume and Issue:
101(1), P. 101542 - 101542
Published: Oct. 15, 2021
Avian
coccidiosis
is
a
major
parasitic
disorder
in
chickens
resulting
from
the
intracellular
apicomplexan
protozoa
Eimeria
that
target
intestinal
tract
leading
to
devastating
disease.
life
cycle
complex
and
consists
of
intra-
extracellular
stages
inducing
potent
inflammatory
response
results
tissue
damage
associated
with
oxidative
stress
lipid
peroxidation,
diarrheal
hemorrhage,
poor
growth,
increased
susceptibility
other
disease
agents,
severe
cases,
mortality.
Various
anticoccidial
drugs
vaccines
have
been
used
prevent
control
this
disorder;
however,
many
drawbacks
reported.
Drug
residues
concerning
consumers
directed
research
toward
natural,
safe,
effective
alternative
compounds.
Phytochemical/herbal
medicine
one
these
natural
alternatives
drugs,
which
considered
an
attractive
way
combat
compliance
"anticoccidial
chemical-free"
regulations.
The
properties
several
herbal
products
(or
their
extracts)
effect
additives
on
avian
based
diminishing
oocyst
output
through
inhibition
or
impairment
invasion,
replication,
development
species
gut
tissues
chickens;
lowering
counts
due
presence
phenolic
compounds
extracts
reacts
cytoplasmic
membranes
causing
coccidial
cell
death;
ameliorating
degree
peroxidation;
facilitating
repair
epithelial
injuries;
decreasing
permeability
induced
by
upregulation
turnover.
This
current
review
highlights
activity
products,
beneficial
effects.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
9
Published: Jan. 10, 2023
The
yellow
polyphenolic
pigment
known
as
curcumin,
originating
from
the
rhizome
of
turmeric
plant
Curcuma
longa
L.,
has
been
utilized
for
ages
in
ancient
medicine,
well
cooking
and
food
coloring.
Recently,
biological
activities
curcumin
have
thoroughly
investigated.
studies
mainly
focused
on
their
antioxidant,
antitumor,
anti-inflammatory,
neuroprotective,
hepatoprotective,
cardioprotective
impacts.
This
review
seeks
to
provide
an
in-depth,
detailed
discussion
usage
within
processing
industries
its
effect
health
support
disease
prevention.
Curcumin’s
bioavailability,
bio-efficacy,
bio-safety
characteristics,
side
effects
quality
standards,
are
also
discussed.
Finally,
curcumin’s
multifaceted
uses,
appeal
enhancement,
agro-industrial
techniques
counteracting
instability
low
nanotechnology
drug
delivery
systems
increase
prospective
clinical
use
tactics
all
Poultry Science,
Journal Year:
2021,
Volume and Issue:
101(2), P. 101584 - 101584
Published: Nov. 8, 2021
Increasing
market
pressure
to
reduce
the
use
of
antibiotics
and
Veterinary
Feed
Directive
2019
have
led
expanded
research
on
alternate
antibiotic
solutions.
This
review
aimed
assess
benefits
using
essential
oils
(EOs)
their
nanoemulsions
(NEs)
as
feed
supplements
for
poultry
potential
alternatives
in
organic
production.
Antibiotics
are
commonly
used
enhance
growth
prevent
diseases
animals
due
antimicrobial
activities.
EOs
a
complex
mixture
volatile
compounds
derived
from
plants
manufactured
via
various
fermentation,
extraction,
steam
distillation
methods.
categorized
into
2
groups
compounds:
terpenes
phenylpropenes.
Differences
among
depend
source
plant
type,
physical
chemical
soil
conditions,
harvest
time,
maturity,
drying
technology
used,
storage
extraction
time.
can
be
therapeutic
purposes
situations
broiler
production
they
possess
antibacterial,
antifungal,
antiparasitic,
antiviral
Several
studies
been
conducted
combinations
or
crude
extracts
bioactive
investigate
complexity
applications
NEs
carrier
systems
that
overcome
nature
EOs,
which
is
major
factor
limiting
application.
being
progressively
improve
bioavailability
lipophilic
components
EOs.
discusses
these
nonantibiotic
Poultry Science,
Journal Year:
2021,
Volume and Issue:
101(2), P. 101590 - 101590
Published: Nov. 9, 2021
In
line
with
the
substantial
increase
in
broiler
industry
worldwide,
Clostridium
perfringens-induced
necrotic
enteritis
(NE)
became
a
continuous
challenge
leading
to
high
economic
losses,
especially
after
banning
antimicrobial
growth
promoters
feeds
by
many
countries.
The
disease
is
distributed
worldwide
either
clinical
or
subclinical
form,
causing
reduction
body
weight
gain
and
feed
conversion
ratio,
impairing
European
Broiler
Index
Production
Efficiency
Factor.
There
are
several
predisposing
factors
development
of
NE.
Clinical
signs
varied
from
inapparent
case
infection
(clostridiosis)
obvious
enteric
(morbidity),
followed
an
mortality
level
(clostridiosis
infection).
laboratory
diagnoses
based
on
history,
signs,
gross
histopathological
lesions,
pathogenic
agent
identification,
serological
testing,
molecular
identification.
Drinking
water
treatment
most
common
route
for
administration
antibiotics,
such
as
penicillin,
bacitracin,
lincomycin.
Strict
hygienic
management
practices
farm,
careful
selection
ingredients
ration
formulation,
use
alternative
antibiotic
additives
all
important
maintaining
efficiency
help
profitability
production.
current
review
highlights
NE
caused
C.
perfringens
explains
advances
understanding
virulence
involved
pathogenesis
special
emphasis
available
alternatives
herbal
extracts
essential
oils
well
vaccines
control
prevention
chickens.
Poultry Science,
Journal Year:
2022,
Volume and Issue:
101(4), P. 101716 - 101716
Published: Jan. 13, 2022
Salmonellosis
is
a
severe
problem
that
threatens
the
poultry
sector
worldwide
right
now.
Salmonella
gallinarium
and
pullorum
(Fowl
typhoid)
are
most
pathogenic
serovars
in
avian
species
leading
to
systemic
infection
resulting
economic
losses
industry.
Nontyphoidal
serotypes
of
(Paratyphoid
disease)
constitute
public
health
hazard
for
their
involvement
food
poisoning
problems
addition
zoonotic
importance.
Also,
distribution
particularly
extensive.
They
resisted
environmental
conditions
made
it
difficult
control
spread
long
time.
Therefore,
current
review
aimed
through
light
on
with
particular
references
its
pathogenesis,
importance,
immune
response
Salmonella,
antibiotics
resistance,
possible
methods
prevention
such
using
promising
alternatives
including
probiotics,
prebiotics,
symbiotics,
organic
acids,
essential
oils,
cinnamaldehyde,
chitosan,
nanoparticles,
vaccines.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(8), P. 1481 - 1481
Published: July 28, 2022
Cancer
is
the
leading
cause
of
death
in
world.
Curcumin
main
ingredient
turmeric
(Curcuma
longa
L.),
and
widely
used
food
industry.
It
shows
anticancer
properties
on
different
types
cancers,
underlying
mechanisms
action
include
inhibiting
cell
proliferation,
suppressing
invasion
migration,
promoting
apoptosis,
inducing
autophagy,
decreasing
cancer
stemness,
increasing
reactive
oxygen
species
production,
reducing
inflammation,
triggering
ferroptosis,
regulating
gut
microbiota,
adjuvant
therapy.
In
addition,
curcumin
demonstrated
clinical
trials.
Moreover,
poor
water
solubility
low
bioavailability
can
be
improved
by
a
variety
nanotechnologies,
which
will
promote
its
effects.
Furthermore,
although
some
adverse
effects,
such
as
diarrhea
nausea,
it
generally
safe
tolerable.
This
paper
an
updated
review
prevention
management
cancers
with
special
attention
to
action.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(10), P. 8874 - 8874
Published: May 17, 2023
Curcumin
is
the
principal
curcuminoid
found
in
rhizomes
of
turmeric.
Due
to
its
therapeutic
action
against
cancer,
depression,
diabetes,
some
bacteria,
and
oxidative
stress,
it
has
been
used
widely
medicine
since
ancient
times.
low
solubility,
human
organism
cannot
completely
absorb
it.
Advanced
extraction
technologies,
followed
by
encapsulation
microemulsion
nanoemulsion
systems,
are
currently
being
improve
bioavailability.
This
review
discusses
different
methods
available
for
curcumin
from
plant
material,
identification
resulting
extracts,
beneficial
effects
on
health,
techniques
into
small
colloidal
systems
that
have
over
past
decade
deliver
this
compound.
