International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(19), P. 11595 - 11595
Published: Sept. 30, 2022
ATP-binding
cassette
subfamily
G
and
tubulin
pharmacological
mechanisms
decrease
the
effectiveness
of
anticancer
drugs
by
modulating
drug
absorption
creating
assembly
through
polymerization.
A
series
natural
synthetic
chalcones
have
been
reported
to
very
good
activity,
with
a
half-maximal
inhibitory
concentration
lower
than
1
µM.
By
modulation,
it
is
observed
in
case
first
mechanism
that
methoxy
substituents
on
aromatic
cycle
acetophenone
residue
substitution
phenyl
nucleus
heterocycle
or
hydroxyl
groups
positive
impact.
To
inhibit
tubulin,
compounds
bind
colchicine
binding
site.
Presence
groups,
amino
heterocyclic
increase
activity.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 1, 2024
Abstract
Combining
existing
drug
therapy
is
essential
in
developing
new
therapeutic
agents
disease
prevention
and
treatment.
In
preclinical
investigations,
combined
effect
of
certain
known
drugs
has
been
well
established
treating
extensive
human
diseases.
Attributed
to
synergistic
effects
by
targeting
various
pathways
advantages,
such
as
reduced
administration
dose,
decreased
toxicity,
alleviated
resistance,
combinatorial
treatment
now
being
pursued
delivering
combat
major
clinical
illnesses,
cancer,
atherosclerosis,
pulmonary
hypertension,
myocarditis,
rheumatoid
arthritis,
inflammatory
bowel
disease,
metabolic
disorders
neurodegenerative
Combinatorial
involves
combining
or
co-delivering
two
more
for
a
specific
disease.
Nanoparticle
(NP)-mediated
delivery
systems,
i.e.,
liposomal
NPs,
polymeric
NPs
nanocrystals,
are
great
interest
wide
range
due
targeted
delivery,
extended
release,
higher
stability
avoid
rapid
clearance
at
infected
areas.
This
review
summarizes
targets
diseases,
clinically
approved
combinations
the
development
multifunctional
emphasizes
strategies
based
on
severe
Ultimately,
we
discuss
challenging
NP-codelivery
translation
provide
potential
approaches
address
limitations.
offers
comprehensive
overview
recent
cutting-edge
NP-mediated
combination
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(21)
Published: Nov. 29, 2022
Abstract
Emerging
as
a
potent
anticancer
treatment,
subcellular
targeted
cancer
therapy
has
drawn
increasing
attention,
bringing
great
opportunities
for
clinical
application.
Here,
two
targeting
strategies
four
main
organelles
(mitochondria,
lysosome,
endoplasmic
reticulum,
and
nucleus),
including
molecule‐
nanomaterial
(inorganic
nanoparticles,
micelles,
organic
polymers,
others)‐based
delivery
or
therapeutic
strategies,
are
summarized.
Phototherapy,
chemotherapy,
radiotherapy,
immunotherapy,
“all‐in‐one”
combination
among
the
covered
in
detail.
Such
materials
constructed
based
on
specific
properties
relevant
mechanisms
of
organelles,
enabling
elimination
tumors
by
inducing
dysfunction
corresponding
destroying
structures.
The
challenges
faced
organelle‐targeting
therapies
also
Looking
forward,
paradigm
with
enhanced
efficacy
compared
to
current
approaches
is
envisioned.
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
43(3), P. 614 - 682
Published: Jan. 19, 2023
Abstract
Ferroptosis
is
an
iron‐dependent
cell
death
program
that
characterized
by
excessive
lipid
peroxidation.
Triggering
ferroptosis
has
been
proposed
as
a
promising
strategy
to
fight
cancer
and
overcome
drug
resistance
in
antitumor
therapy.
Understanding
the
molecular
interactions
structural
features
of
ferroptosis‐inducing
compounds
might
therefore
open
door
efficient
pharmacological
strategies
against
aggressive,
metastatic,
therapy‐resistant
cancer.
We
here
summarize
mechanisms
requirements
small
molecules
target
central
players
ferroptosis.
Focus
placed
on
(i)
glutathione
peroxidase
(GPX)
4,
only
GPX
isoenzyme
detoxifies
complex
membrane‐bound
hydroperoxides,
(ii)
cystine/glutamate
antiporter
system
X
c
−
for
regeneration,
(iii)
redox‐protective
transcription
factor
nuclear
erythroid
2‐related
(NRF2),
(iv)
GPX4
repression
combination
with
induced
heme
degradation
via
oxygenase‐1.
deduce
common
ferroptotic
activity
highlight
challenges
development.
Moreover,
we
critically
discuss
potential
natural
products
lead
structures
provide
comprehensive
overview
structurally
diverse
biogenic
bioinspired
trigger
iron
oxidation,
inhibition
thioredoxin/thioredoxin
reductase
or
less
defined
modes
action.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116432 - 116432
Published: March 22, 2024
Oxidative
stress
results
from
a
persistent
imbalance
in
oxidation
levels
that
promotes
oxidants,
playing
crucial
role
the
early
and
sustained
phases
of
DNA
damage
genomic
epigenetic
instability,
both
which
are
intricately
linked
to
development
tumors.
The
molecular
pathways
contributing
carcinogenesis
this
context,
particularly
those
related
double-strand
single-strand
breaks
DNA,
serve
as
indicators
due
cancer
cases,
well
factors
instability
through
ectopic
expressions.
has
been
considered
therapeutic
target
for
many
years,
an
increasing
number
studies
have
highlighted
promising
effectiveness
natural
products
treatment.
In
regard,
we
present
significant
research
on
targeting
oxidative
using
molecules
underscore
essential
cancer.
consequences
stress,
especially
also
offer
prospects.
use
epi-drugs
capable
modulating
reorganizing
network
is
beginning
emerge
remarkably.
review,
emphasize
close
connections
between
tumor
transformation,
while
highlighting
substances
antioxidants
anti-tumoral
context.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
