Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 135 - 151
Published: Oct. 1, 2024
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Language: Английский
Citations
283
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102324 - 102324
Published: May 16, 2024
Language: Английский
Citations
14
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Nov. 19, 2024
Abstract Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons poses great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it urgent need explore other potential mechanism develop novel approach delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), versatile epigenetic regulators responsible gene transcription via binding histones or non-histone substrates, have grabbed considerable attention in drug discovery. There also substantial evidences supporting aberrant expressions and/activities HDAC isoforms reported epilepsy inhibitors (HDACi) been purposes this condition. However, specific mechanisms underlying role HDACs progression not fully understood. Herein, we reviewed basic information HDACs, summarized recent findings associated with roles diverse subunits discussed regulatory which affected development epilepsy. Additionally, provided brief discussion on as promising targets treatment, serving valuable reference study clinical translation field.
Language: Английский
Citations
14
Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: March 11, 2024
Exosomes, vesicular structures originating from cells, participate in the conveyance of proteins and nucleic acids. Presently, centrality epigenetic modifications neurological disorders is widely acknowledged. Exosomes exert influence over various phenomena, thereby modulating post-transcriptional regulatory processes contingent upon their constituent makeup. Consequently, heightened attention directed toward exosomes as instigators alterations has burgeoned recent years. Notably, serve vehicles for delivering methyltransferases to recipient cells. More significantly, non-coding RNAs, particularly microRNAs (miRNAs), represent pivotal contents within exosomes, wielding capacity expression diverse factors cerebral milieu. The transfer these exosomal amidst brain encompassing neuronal cells microglia, assumes a critical role genesis progression disorders, also, this not limited it may deal with any human disease, such cancer, cardiovascular diseases. This review will concentrate on elucidating regulation exosome-induced events its subsequent ramifications A more profound comprehension involvement exosome-mediated contributes awareness etiology advancement afflictions.
Language: Английский
Citations
8
Epigenomes, Journal Year: 2024, Volume and Issue: 8(2), P. 22 - 22
Published: June 4, 2024
The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally spatially with extracellular microenvironment. three major cell types in brain, i.e., neurons two glial cells (astrocytes oligodendrocytes), are generated from common multipotent neural stem (NSCs) throughout life. However, NSCs do not have this multipotentiality beginning. During cortical development, sequentially obtain abilities to differentiate into response combinations spatiotemporally modulated cell-intrinsic epigenetic alterations extrinsic factors. After completion brain a limited population remains adult continues produce (adult neurogenesis), thus contributing learning memory. Many biological aspects neurogenesis changes via behavioral control NSCs. Epigenetic dysregulation has also been implicated pathogenesis various diseases. Here, we present recent advances regulation NSC behavior its disorders.
Language: Английский
Citations
6
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 115995 - 115995
Published: Jan. 20, 2024
Language: Английский
Citations
5
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 975, P. 176641 - 176641
Published: May 14, 2024
Language: Английский
Citations
4
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 553 - 553
Published: May 29, 2024
Parkinson’s disease (PD), multiple sclerosis (MS), and amyotrophic lateral (ALS) are examples of neurodegenerative movement disorders (NMDs), which defined by a gradual loss motor function that is frequently accompanied cognitive decline. Although genetic abnormalities have long been acknowledged as significant factors, new research indicates epigenetic alterations crucial for the initiation development disease. This review delves into complex interactions exist between pathophysiology NMDs mechanisms such DNA methylation, histone modifications, non-coding RNAs. Here, we examine how these changes could affect protein aggregation, neuroinflammation, gene expression patterns, thereby influencing viability functionality neurons. Through clarification terrain underpinning disorders, this seeks to enhance comprehension underlying illness augment creation innovative therapeutic strategies.
Language: Английский
Citations
4
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(3), P. 887 - 899
Published: May 17, 2024
JOURNAL/nrgr/04.03/01300535-202503000-00032/figure1/v/2025-03-16T133445Z/r/image-tiff Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin Parkinson’s disease. However, the mechanism by which Sal mediates dopaminergic neuronal death remains unclear. In this study, we found significantly enhanced global level of N 6 -methyladenosine (m A) RNA methylation in PC12 cells, mainly inducing downregulation expression m A demethylases fat mass obesity-associated protein (FTO) alkB homolog 5 (ALKBH5). sequencing analysis showed downregulated Hippo signaling pathway. The reader YTH domain-containing family 2 (YTHDF2) promoted degradation A-containing Yes-associated 1 ( YAP1 ) mRNA, downstream key effector Additionally, autophagy, indicating mutual regulation between autophagy can lead to neurotoxicity. These findings reveal role on suggest may act as inducer mediating through autophagy. Our results provide greater insights into neurotoxic effects isoquinolines compared other studies be reference for assessing involvement pathogenesis
Language: Английский
Citations
4
NeuroMarkers., Journal Year: 2025, Volume and Issue: unknown, P. 100037 - 100037
Published: Feb. 1, 2025
Language: Английский
Citations
0