Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: April 1, 2024
Spinal
cord
injury
(SCI)-induced
neuroinflammation
and
oxidative
stress
(OS)
are
crucial
events
causing
neurological
dysfunction.
Aconitate
decarboxylase
1
(ACOD1)
its
metabolite
itaconate
(Ita)
inhibit
inflammation
OS
by
promoting
alkylation
of
Keap1
to
induce
Nrf2
expression;
however,
it
is
unclear
whether
there
another
pathway
regulating
their
effects
in
inflammation-activated
microglia
after
SCI.
Adult
male
C57BL/6
ACOD1-/-
mice
wild-type
(WT)
littermates
were
subjected
a
moderate
thoracic
spinal
contusion.
The
degree
the
injured
assessed
using
qPCR,
western
blot,
flow
cytometry,
immunofluorescence,
trans-well
assay.
We
then
employed
immunoprecipitation-western
chromatin
immunoprecipitation
(ChIP)-PCR,
dual-luciferase
assay,
immunofluorescence-confocal
imaging
examine
molecular
mechanisms
ACOD1.
Finally,
locomotor
function
was
evaluated
with
Basso
Mouse
Scale
footprint
Both
vitro
vivo,
transcriptional
blockage
ACOD1
exhibited
more
severe
levels
OS,
which
expression
p62/Keap1/Nrf2
down-regulated.
Furthermore,
silencing
exacerbated
dysfunction
SCI
mice.
Administration
exogenous
Ita
or
4-octyl
reduced
p62
phosphorylation.
Besides,
capable
interacting
phosphorylated
enhance
activation,
turn
further
promoted
transcription
Here,
we
identified
an
unreported
ACOD1-p62-Nrf2-ACOD1
feedback
loop
exerting
anti-inflammatory
anti-OS
inflammatory
microglia,
demonstrated
neuroprotective
role
SCI,
different
from
that
endogenous
Ita.
present
study
extends
functions
uncovers
marked
property
differences
between
attenuated
injury.
ACOD1,
not
itaconate,
interacted
p-p62
facilitate
nuclear
translocation.
microglia.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(1), P. 229 - 229
Published: Jan. 5, 2021
Resveratrol
(3,4',5-trihy-
droxystilbene),
a
natural
phytoalexin
polyphenol,
exhibits
anti-oxidant,
anti-inflammatory,
and
anti-carcinogenic
properties.
This
is
well-absorbed
rapidly
extensively
metabolized
in
the
body.
Inflammation
an
adaptive
response,
which
could
be
triggered
by
various
danger
signals,
such
as
invasion
microorganisms
or
tissue
injury.
In
this
review,
anti-inflammatory
activity
mechanism
of
resveratrol
modulates
inflammatory
response
are
examined.
Multiple
experimental
studies
that
illustrate
regulatory
mechanisms
immunomodulatory
function
both
vivo
vitro.
The
data
acquired
from
those
discussed.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(17), P. 5327 - 5327
Published: Sept. 2, 2021
Natural
products
derived
from
plants,
as
well
their
bioactive
compounds,
have
been
extensively
studied
in
recent
years
for
therapeutic
potential
a
variety
of
neurodegenerative
diseases
(NDs),
including
Alzheimer’s
(AD),
Huntington’s
(HD),
and
Parkinson’s
(PD)
disease.
These
are
characterized
by
progressive
dysfunction
loss
neuronal
structure
function.
There
has
little
progress
designing
efficient
treatments,
despite
impressive
breakthroughs
our
understanding
NDs.
In
the
prevention
therapy
NDs,
use
natural
may
provide
great
opportunities;
however,
many
clinical
issues
emerged
regarding
use,
primarily
based
on
lack
scientific
support
or
proof
effectiveness
patient
safety.
Since
neurodegeneration
is
associated
with
myriad
pathological
processes,
targeting
multi-mechanisms
action
neuroprotection
approaches
that
include
preventing
cell
death
restoring
function
damaged
neurons
should
be
employed.
treatment
AD
PD,
neuroprotective
agents.
This
current
review
will
highlight
numerous
compounds
thatexert
effects
pathologies
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(1), P. 147 - 147
Published: Jan. 7, 2023
Nitric
oxide
(NO)
plays
several
key
roles
in
the
functionality
of
an
organism,
and
it
is
usually
released
numerous
organs
tissues.
There
are
mainly
three
isoforms
enzyme
that
produce
NO
starting
from
metabolism
arginine,
namely
endothelial
nitric
synthase
(eNOS),
inducible
(iNOS),
neuronal
(nNOS).
The
expression
activity
these
depends
on
activation/deactivation
different
signaling
pathways
at
intracellular
level
following
physiological
pathological
stimuli.
Compounds
natural
origin
such
as
polyphenols,
which
obtainable
through
diet,
have
been
widely
studied
recent
years
vivo
vitro
investigations
for
their
ability
to
induce
or
inhibit
release,
depending
tissue.
In
this
review,
we
aim
disclose
scientific
evidence
relating
main
dietary
polyphenols
modulation
involved
and/or
NOS
isoforms.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(7), P. 1203 - 1203
Published: March 29, 2025
Alzheimer's
disease
(AD)
is
a
complex
neurodegenerative
disorder
characterized
by
progressive
cognitive
decline,
memory
loss,
and
behavioral
changes.
It
poses
significant
global
health
challenge.
AD
associated
with
the
accumulation
of
amyloid-β
(Aβ)
plaques
neurofibrillary
tangles
(NFTs)
in
brain,
along
chronic
inflammation,
dysfunctional
neurons,
synapse
loss.
While
prevalence
continues
to
rise,
current
FDA-approved
drugs
offer
only
limited
effectiveness.
Emerging
evidence
suggests
that
obesity,
insulin
resistance
(IR),
type
2
diabetes
mellitus
(T2DM)
are
also
implicated
pathogenesis,
epidemiological
studies
animal
models
confirming
impact
IR
on
Aβ
accumulation,
high-fat
diets
exacerbating
accumulation.
Since
neuroinflammation
activated
involves
nuclear
factor
kappa-light-chain-enhancer
B
cell
(NF-κB)
pathway,
inhibition
NF-κB
NLRP3
inflammasome
activation
potential
therapeutic
strategies
AD.
Bioactive
compounds,
including
polyphenols
(resveratrol,
epigallocatechin-3-gallate,
curcumin,
quercetin),
omega-3
polyunsaturated
fatty
acids,
show
promising
results
clinical
trials
for
reducing
levels,
improving
cognition
modulating
signaling
pathways
This
review
explores
interplay
between
IR,
pathology,
emphasizing
dietary
compounds
their
role
oxidative
stress,
as
viable
prevention
treatment.
By
integrating
findings,
observational
studies,
trials,
this
aims
provide
comprehensive
understating
how
metabolic
dysfunctions
bioactive
influence
progression.
