Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 7, 2024
Abstract
Conjugated
polymers
(CPs)
have
promising
applications
in
biomedical
fields,
such
as
disease
monitoring,
real‐time
imaging
diagnosis,
and
treatment.
As
a
luminescent
material
with
tunable
emission,
high
brightness
excellent
stability,
CPs
are
widely
used
fluorescent
probes
biological
detection
imaging.
Rational
molecular
design
structural
optimization
broadened
absorption/emission
range
of
CPs,
which
more
conductive
for
diagnosis
precision
therapy.
This
review
provides
comprehensive
overview
recent
advances
the
application
aiming
to
elucidate
their
functional
relationships.
The
fluorescence
properties
mechanism
signal
amplification
first
discussed,
followed
by
an
elucidation
emerging
detection.
Subsequently,
CPs‐based
systems
therapeutic
strategies
illustrated
systematically.
Finally,
advancements
utilizing
electroactive
materials
bioelectronic
devices
also
investigated.
Moreover,
challenges
outlooks
medicine
discussed.
Through
this
systematic
review,
it
is
hoped
highlight
frontier
progress
promote
new
breakthroughs
fundamental
research
clinical
transformation.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(37)
Published: June 26, 2021
Abstract
Owing
to
the
unique
advantages
of
photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT)
conducted
over
near‐infrared‐II
(NIR‐II)
window,
development
high‐efficiency
optical
agents
with
NIR‐II
light
responsiveness
is
great
significance.
Despite
diversity
developed
for
PAI
PTT,
most
them
are
based
on
inorganic
nanomaterials
small
molecular
dyes,
whose
biosafety
photostability
need
be
further
assessed,
respectively.
Organic
semiconducting
macromolecular
dyes
(OSMDs)
featuring
a
large
backbone
becoming
alternative
candidates
PTT
owing
their
reliable
biocompatibility,
durable
photostability,
ideal
conversion
capability.
This
paper
reviews
current
progress
OSMD‐based
in
window.
The
three
main
types
OSMDs
different
skeleton
architectures
introduced,
applications
(tumor
imaging,
stem
cell
tracking,
vasculature
imaging)
ablation)
described.
Viable
strategies
improving
performance
discussed.
Finally,
some
major
issues
faced
by
raised,
future
directions
analyzed.
Journal of Nanobiotechnology,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: Dec. 16, 2021
Abstract
Despite
the
exciting
breakthroughs
in
medical
technology,
cancer
still
accounts
for
one
of
principle
triggers
death
and
conventional
therapeutic
modalities
often
fail
to
attain
an
effective
cure.
Recently,
nanobiotechnology
has
made
huge
advancement
therapy
with
gigantic
application
potential
because
their
ability
achieving
precise
controlled
drug
release,
elevating
solubility
reducing
adverse
effects.
Carbon
nanotubes
(CNTs),
most
promising
carbon-related
nanomaterials,
have
already
achieved
much
success
biomedical
field.
Due
excellent
optical
property,
thermal
electronic
conductivity,
easy
functionalization
high
loading
capacity,
CNTs
can
be
applied
a
multifunctional
way
treatment
diagnosis.
In
this
review,
we
will
give
overview
recent
progress
CNT-based
delivery
systems
theranostics,
which
emphasizes
targetability
intracellular
components
tumor
cells
extracellular
elements
microenvironment.
Moreover,
detailed
introduction
on
how
penetrate
inside
reach
sites
action
achieve
effects,
as
well
diagnostic
applications
highlighted.
Graphic
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 10, 2023
Rapid
advancements
in
materials
science
and
nanotechnology,
intertwined
with
oncology,
have
positioned
photothermal
therapy
(PTT)
as
a
promising
noninvasive
treatment
strategy
for
cancer.
The
breast's
superficial
anatomical
location
aesthetic
significance
render
breast
cancer
particularly
pertinent
candidate
the
clinical
application
of
PTT
following
melanoma.
This
review
comprehensively
explores
research
conducted
on
various
types
nanoparticles
employed
elaborates
their
specific
roles
mechanisms
action.
integration
existing
therapies
is
scrutinized,
underscoring
its
potential
synergistic
outcomes.
Additionally,
underlying
consequential
modifications
to
tumor
microenvironment
after
are
elaborated
from
medical
perspective.
Future
directions
suggested,
an
emphasis
development
integrative
platforms
that
combine
multiple
therapeutic
approaches
optimization
nanoparticle
synthesis
enhanced
efficacy.
goal
push
boundaries
toward
comprehensive,
clinically
applicable
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(17)
Published: March 3, 2022
Much
effort
is
devoted
to
develop
agents
with
superior
photoacoustic/photothermal
properties
for
improved
disease
diagnosis
and
treatment.
Herein,
a
new
fused
two
isoindigo
(DIID)-based
semiconducting
conjugated
polymer
(named
PBDT-DIID)
rationally
designed
synthesized
strong
near-infrared
absorption
band
ranging
from
700
1000
nm.
Water-dispersing
nanoparticles
(NPs)
of
PBDT-DIID
are
prepared
good
biocompatibility
rather
high
photothermal
conversion
efficiency
(70.6%),
as
the
active
excited-state
intramolecular
twist
around
central
double
bonds
in
DIID
permits
most
absorbed
excitation
energy
flow
heat
deactivation
pathway
through
internal
conversion.
The
photoacoustic
signal
can
be
further
magnified
by
incorporation
polylactide
(PLA)
NP
core
confine
generated
within
NPs.
resultant
doped
NPs
show
excellent
performance
imaging-guided
therapy
an
orthotopic
4T1
breast
tumor-bearing
mouse
model.
It
also
found
that
effect
safe
quite
efficacious
highly
improve
root
canal
treatment
outcome
heating
1%
NaClO
solution
inside
upon
808
nm
laser
irradiation
human
extracted
tooth
infection
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(29)
Published: June 9, 2023
Abstract
Growing
concern
about
photothermal
tumor
therapy
(PTT)
as
a
promising
alternative
to
conventional
liver
cancer
treatment,
which
is
treatment
strategy
that
utilizes
near‐infrared
(NIR)
light‐induced
agents
(PTAs)
yield
effects
localize
thermal
damage
for
tumors.
Herein,
given
the
gap
between
experimental
research
and
clinical
application,
this
review
seeks
timely
summarize
highlight
recent
progress
of
PTAs
used
in
vivo
vitro
last
five‐year.
The
implications
various
on
multifunctional
conversion
capability,
structure‐performance
correlations
PTT,
together
with
evaluation
their
potential
application
are
systematically
dissected
further
dig
out
what
buried
mechanism
is.
Besides,
higher
requirements
put
forward
discrepancies
crucial
issues
faced
by
different
PTT
related
medical
technical
obstacles
being
conquered,
lays
solid
theoretical
foundation
field
oncology
whole,
especially
cancer.
Finally,
it
expected
can
present
valuable
guidance
design
efficient,
photostability,
biosafety‐aware
anticancer
while
stepping
into
fast
traffic
lane
from
bench
bedside
foreseeable
future.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(8), P. 7394 - 7405
Published: April 3, 2023
Although
photothermal
therapy
(PTT)
has
thrived
as
a
promising
treatment
for
drug-resistant
bacterial
infections
by
avoiding
the
abuse
of
antibiotics,
remaining
challenges
that
limit
efficiency
are
poor
targeting
properties
infected
lesions
and
low
penetration
to
cell
membrane
Gram-negative
bacteria.
Herein,
we
developed
biomimetic
neutrophil-like
aggregation-induced
emission
(AIE)
nanorobot
(CM@AIE
NPs)
precise
inflammatory
site
homing
efficient
PTT
effects.
Due
their
surface-loaded
neutrophil
membranes,
CM@AIE
NPs
can
mimic
source
thus
interact
with
immunomodulatory
molecules
would
otherwise
target
endogenous
neutrophils.
Coupled
secondary
near-infrared
region
absorption
excellent
AIE
luminogens
(AIEgens),
localization,
in
sites
be
achieved,
thereby
minimizing
damage
surrounding
normal
tissues.
Moreover,
NP-mediated
was
stimulated
vivo
980
nm
laser
irradiation,
which
contributed
extent
therapeutic
depth
limited
skin
The
good
biocompatibility
vitro
antibacterial
effects
prove
provide
strategy
broad-spectrum
applications.
