Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100572 - 100572
Published: Feb. 1, 2023
The
extracellular
matrix
(ECM),
an
integral
component
of
all
organs,
is
inherently
tissue
adhesive
and
plays
a
pivotal
role
in
regeneration
remodeling.
However,
man-made
three-dimensional
(3D)
biomaterials
that
are
designed
to
mimic
ECMs
do
not
intrinsically
adhere
moisture-rich
environments
often
lack
open
macroporous
architecture
required
for
facilitating
cellularization
integration
with
the
host
post-implantation.
Furthermore,
most
these
constructs
usually
entail
invasive
surgeries
potentially
risk
infection.
To
address
challenges,
we
recently
engineered
biomimetic
cryogel
scaffolds
syringe
injectable
while
exhibiting
unique
physical
properties,
including
strong
bioadhesive
properties
tissues
organs.
These
catechol-containing
cryogels
were
prepared
from
naturally-derived
polymers
such
as
gelatin
hyaluronic
acid
functionalized
mussel-inspired
dopamine
(DOPA)
impart
properties.
We
found
using
glutathione
antioxidant
incorporating
DOPA
into
via
PEG
spacer
arm
led
highest
adhesion
improved
overall,
whereas
DOPA-free
weakly
adhesive.
As
shown
by
qualitative
quantitative
tests,
DOPA-containing
able
strongly
several
animal
organs
heart,
small
intestine,
lung,
kidney,
skin.
unoxidized
(i.e.,
browning-free)
showed
negligible
cytotoxicity
toward
murine
fibroblasts
prevented
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 14, 2022
Islet
transplantation
is
a
promising
approach
for
the
treatment
of
type
1
diabetes
(T1D).
Currently,
clinical
islet
limited
by
allo
-
and
autoimmunity
that
may
cause
partial
or
complete
loss
function
within
short
period
time,
long-term
immunosuppression
required
to
prevent
rejection.
Encapsulation
into
semipermeable
biomaterials
provides
strategy
allows
nutrients,
oxygen
secreted
hormones
diffuse
through
membrane
while
blocking
immune
cells
like
out
capsule,
allowing
graft
survival
avoiding
use
immunosuppression.
In
recent
years,
variety
engineering
strategies
have
been
developed
improve
composition
properties
encapsulation
materials
explore
practicality
cell
from
different
sources.
particular,
porcine
co-encapsulation
with
other
by-standing
active
ingredients
promoting
functionality,
attracted
significant
research
efforts.
Hydrogels
widely
used
as
well
therapeutic
applications
including
tissue
engineering,
carriers
drug
delivery.
Here,
we
review
current
status
various
hydrogel
biomaterials,
natural
synthetic,
particular
focus
on
applications.
Natural
hydrophilic
polymers
include
polysaccharides
(starch,
cellulose,
alginic
acid,
hyaluronic
chitosan)
peptides
(collagen,
poly-L-lysine,
poly-L-glutamic
acid).
Synthetic
alcohol,
acrylic
acid
their
derivatives
[poly
(acrylic
acid),
poly
(methacrylic
poly(acrylamide)].
By
understanding
advantages
disadvantages
sources
types,
appropriate
encapsuling
methods
can
be
designed
selected
needed
efficacy
duration
islet.
capsule
emerging
future
T1D.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(6)
Published: Nov. 28, 2022
Marine
organisms
provide
novel
and
broad
sources
for
the
preparations
applications
of
biomaterials.
Since
urgent
requirement
bio‐hydrogels
to
mimic
tissue
extracellular
matrix
(ECM),
natural
biomacromolecule
hydrogels
derived
from
marine
have
received
increasing
attention.
Benefiting
their
outstanding
bioactivity
biocompatibility,
many
attempts
been
made
reconstruct
ECM
components
by
applying
marine‐derived
hydrogels.
Moreover,
successfully
applied
in
biomedicine
means
microfluidics,
electrospray,
bioprinting.
In
this
review,
classification
characteristics
are
summarized.
particular,
role
development
biomaterials
is
also
introduced.
Then,
recent
advances
bio‐fabrication
strategies
various
hydrogel
materials
focused
upon.
Besides,
influences
types
on
functions
biomedical
discussed
depth.
Finally,
critical
reflections
limitations
future
presented.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(1), P. 814 - 814
Published: Jan. 3, 2023
The
repair
of
severe
bone
defects
is
still
a
formidable
clinical
challenge,
requiring
the
implantation
grafts
or
substitute
materials.
development
three-dimensional
(3D)
bioprinting
has
received
considerable
attention
in
tissue
engineering
over
past
decade.
However,
3D
printing
limitation.
It
only
takes
into
account
original
form
printed
scaffold,
which
inanimate
and
static,
not
suitable
for
dynamic
organisms.
With
emergence
stimuli-responsive
materials,
four-dimensional
(4D)
become
next-generation
solution
biological
engineering.
combines
concept
time
with
printing.
Over
time,
4D-printed
scaffolds
change
their
appearance
function
response
to
environmental
stimuli
(physical,
chemical,
biological).
In
conclusion,
4D
fourth
dimension
(time)
printing,
provides
unprecedented
potential
repair.
this
review,
we
will
discuss
latest
research
on
shape
memory
materials
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
12(1), P. 8 - 56
Published: Oct. 25, 2023
Hydrogels
have
established
their
significance
as
prominent
biomaterials
within
the
realm
of
biomedical
research.
However,
injectable
hydrogels
garnered
greater
attention
compared
with
conventional
counterparts
due
to
excellent
minimally
invasive
nature
and
adaptive
behavior
post-injection.
With
rapid
advancement
emerging
chemistry
deepened
understanding
biological
processes,
contemporary
been
endowed
an
"intelligent"
capacity
respond
various
endogenous/exogenous
stimuli
(such
temperature,
pH,
light
magnetic
field).
This
innovation
has
spearheaded
revolutionary
transformations
across
fields
such
tissue
engineering
repair,
controlled
drug
delivery,
disease-responsive
therapies,
beyond.
In
this
review,
we
comprehensively
expound
upon
raw
materials
(including
natural
synthetic
materials)
principles
these
advanced
hydrogels,
concurrently
providing
a
detailed
discussion
prevalent
strategies
for
conferring
stimulus
responsiveness.
Finally,
elucidate
latest
applications
"smart"
stimuli-responsive
in
domain,
offering
insights
into
prospects.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100572 - 100572
Published: Feb. 1, 2023
The
extracellular
matrix
(ECM),
an
integral
component
of
all
organs,
is
inherently
tissue
adhesive
and
plays
a
pivotal
role
in
regeneration
remodeling.
However,
man-made
three-dimensional
(3D)
biomaterials
that
are
designed
to
mimic
ECMs
do
not
intrinsically
adhere
moisture-rich
environments
often
lack
open
macroporous
architecture
required
for
facilitating
cellularization
integration
with
the
host
post-implantation.
Furthermore,
most
these
constructs
usually
entail
invasive
surgeries
potentially
risk
infection.
To
address
challenges,
we
recently
engineered
biomimetic
cryogel
scaffolds
syringe
injectable
while
exhibiting
unique
physical
properties,
including
strong
bioadhesive
properties
tissues
organs.
These
catechol-containing
cryogels
were
prepared
from
naturally-derived
polymers
such
as
gelatin
hyaluronic
acid
functionalized
mussel-inspired
dopamine
(DOPA)
impart
properties.
We
found
using
glutathione
antioxidant
incorporating
DOPA
into
via
PEG
spacer
arm
led
highest
adhesion
improved
overall,
whereas
DOPA-free
weakly
adhesive.
As
shown
by
qualitative
quantitative
tests,
DOPA-containing
able
strongly
several
animal
organs
heart,
small
intestine,
lung,
kidney,
skin.
unoxidized
(i.e.,
browning-free)
showed
negligible
cytotoxicity
toward
murine
fibroblasts
prevented
