Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(51)
Published: Oct. 10, 2022
Abstract
Supramolecular
self‐assembly
of
near‐infrared
(NIR)
dyes
are
believed
to
be
a
promising
strategy
design
effective
photothermal
agents
for
tumor
therapy
(PTT).
However,
due
the
uncontrollable
intermolecular
interactions,
accurately
fine‐tuning
aggregated
morphology
NIR
through
adjusting
their
supramolecular
is
challenging.
Here,
based
on
organic–metal
coordination
interaction,
facile
proposed
adjust
heptamethine
cyanine
(Cy7)
dyes,
well‐known
dyes.
Three
hydrophilic
Cy7
derivatives
Cy‐nCOOH
(
n
=
1,
2,
and
3)
synthesized,
then
coordinated
with
Cu
2+
obtain
different
aggregates.
Cy‐1COOH/Cu
aggregates
form
partial
J‐aggregates.
Cy‐2COOH/Cu
amorphous.
Noteworthily,
Cy‐3COOH/Cu
exhibit
significant
H‐type
aggregation.
Moreover,
show
about
threefold
higher
conversion
efficiency
obviously
enhanced
photostability
than
It
demonstrated
that
H‐aggregates
face‐to‐face
π–π
stacking
greatly
quench
fluorescence
inhibit
singlet
oxygen
1
O
2
)
production,
which
lead
improved
performances.
In
vitro
in
vivo
experiments
demonstrate
remarkable
PTT
H‐aggregates.
This
study
provides
new
insight
into
how
precisely
control
molecular
aggregation
organic
phototherapy.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Sept. 27, 2023
Abstract
Near-infrared
(NIR)
organic
small
molecule
dyes
(OSMDs)
are
effective
photothermal
agents
for
therapy
(PTT)
due
to
their
advantages
of
low
cost
and
toxicity,
good
biodegradation,
strong
NIR
absorption
over
a
wide
wavelength
range.
Nevertheless,
OSMDs
have
limited
applicability
in
PTT
conversion
efficiency
inadequate
destruction
tumor
regions
that
nonirradiated
by
light.
However,
they
can
also
act
as
photosensitizers
(PSs)
produce
reactive
oxygen
species
(ROS),
which
be
further
eradicated
using
ROS-related
therapies
address
the
above
limitations
PTT.
In
this
review,
synergistic
mechanism,
composition,
properties
photodynamic
(PDT)–PTT
nanoplatforms
were
comprehensively
discussed.
addition,
some
specific
strategies
improving
combined
PDT
based
on
cancer
completely
eradicate
cells
outlined.
These
include
performing
image-guided
co-therapy,
enhancing
infiltration,
increasing
H
2
O
or
microenvironment,
loading
anticancer
drugs
onto
enable
with
phototherapy
chemotherapy.
Meanwhile,
intriguing
prospects
challenges
treatment
modality
summarized
focus
future
trends
its
clinical
application.
Graphical
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(21)
Published: Feb. 22, 2023
Abstract
Infectious
diseases
(such
as
wound
infections)
caused
by
pathogenic
microorganisms
can
lead
to
serious
consequences
and
even
threaten
life.
The
emergence
of
drug‐resistant
bacteria
has
severely
prevented
the
validity
traditional
antibiotics.
Therefore,
developing
novel
antimicrobial
strategies
without
holds
great
promise
for
maximizing
efficacy
minimizing
risk
drug‐resistance
resistant
bacterial
infections.
Herein,
near‐infrared
(NIR)‐absorbing
A–D–A
type
conjugated
oligomers
with
a
tunable
backbone
are
designed
synthesized
regulating
their
photothermal
conversion.
After
being
assembled
into
nanoparticles,
oligomer
CP‐F8P
nanoparticles
(NPs)
containing
strong
electron‐donating
component
show
strongest
conversion
efficiency
81.6%.
low
concentration
NPs
receive
over
99%
against
Amp
r
E.
coli
,
S.
aureus
C.
albicans
upon
NIR
irradiation,
phototherapy
treatment
effectively
promote
healing
in
diabetic
mice
good
biocompatibility.
This
work
provides
ideas
design
efficient
NIR‐activated
reagents
microbial
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(23)
Published: April 5, 2024
Abstract
Reactive
oxygen
species
(ROS)
have
become
an
effective
tool
for
tumor
treatment.
The
combination
of
photodynamic
therapy
(PDT)
and
chemodynamic
(CDT)
takes
advantage
various
ROS
enhances
therapeutic
effects.
However,
the
activation
CDT
usually
occurs
before
PDT,
which
hinders
sustained
maintenance
hydroxyl
radicals
(⋅OH)
reduces
treatment
efficiency.
Herein,
we
present
a
light‐triggered
nano‐system
based
on
molecular
aggregation
regulation
converting
cancer
from
PDT/photothermal
(PTT)
to
long‐lasting
CDT.
ordered
J‐aggregation
properties
cyanine
moiety
while
simultaneously
suppressing
capabilities
copper‐porphyrin
moiety.
Upon
light
irradiation,
Cu‐PCy
JNPs
demonstrate
strong
photothermal
Meanwhile,
triggers
rapid
degradation
backbone,
leading
destruction
J‐aggregation.
As
result,
is
sequentially
activated,
generation
⋅OH
observed
up
48
hours,
causing
potent
cellular
oxidative
stress
apoptosis.
Due
their
excellent
accumulation,
exhibit
in
vivo
ablation
through
therapy.
This
work
provides
new
approach
effectively
prolonging
activity
ROS‐based
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 5, 2024
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
is
burgeoning
because
of
its
higher
fidelity
monitoring
physiological
and
pathological
processes
than
clinical
visible/the
fluorescence
imaging.
Notably,
heavily
dependent
on
agents.
So
far,
indocyanine
green,
one
polymethine
dyes,
with
good
biocompatibility
renal
clearance
only
dye
approved
by
Food
Drug
Administration,
but
it
shows
relatively
low
NIR-II
brightness.
Importantly,
tremendous
efforts
are
devoted
to
synthesizing
dyes
for
preclinically
clinically.
They
have
shown
feasibility
customization
structure
properties
fulfill
various
needs
therapy.
Herein,
a
timely
update
special
focus
molecular
design
strategies
fluorescent,
photoacoustic,
multimodal
imaging,
offered.
Furthermore,
progress
sensing
biomarkers
even
reporting
drug
release
illustrated.
Moreover,
imaging-guided
therapies
summarized
regarding
chemo-,
photothermal,
photodynamic,
approaches.
In
addition,
artificial
intelligence
pointed
out
potential
expedite
development.
This
comprehensive
review
will
inspire
interest
among
wide
audience
offer
handbook
people
an
dyes.
