Manganese‐Based Tumor Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(19)

Published: Sept. 19, 2022

Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles host immune system, hematopoiesis, endocrine function, oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible show versatile applications nanomedicine, particular utilized tumor immunotherapy the following ways: 1) acting as a nanocarrier deliver immunotherapeutic agents for immunotherapy; 2) serving adjuvant regulate microenvironment enhance 3) activating host's system through cGAS‐STING pathway trigger 4) real‐time monitoring effect by magnetic resonance imaging (MRI) since Mn 2+ ions ideal MRI contrast agent which can significantly T 1 ‐weighted signal after binding proteins. This comprehensive review focuses on most recent progress of nanoplatforms immunotherapy. The characteristics first discussed guide design multifunctional nanoplatforms. Then biomedical nanoplatforms, including alone, immunotherapy‐involved multimodal synergistic therapy, imaging‐guided detail. Finally, challenges future developments highlighted.

Language: Английский

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Nanozyme Catalytic Turnover and Self-Limited Reactions

ACS Nano, Journal Year: 2021, Volume and Issue: 15(10), P. 15645 - 15655

Published: Oct. 8, 2021

Enzymes have catalytic turnovers. The field of nanozyme endeavors to engineer nanomaterials as enzyme mimics. However, a discrepancy in the definition "nanozyme concentration" has led an unrealistic calculation To date, most reported works considered either atomic concentration or nanoparticle (NP) concentration. These assumptions can lead significant under- overestimation activity nanozymes. In this article, we review some classic nanozymes including Fe3O4, CeO2, and gold nanoparticles (AuNPs) with focus on activities. We argue that only surface atoms should be active sites, then turnover numbers rates were recalculated based atoms. According calculations, peroxidase Fe3O4 NPs is validated. AuNPs are self-limited when performing glucose-oxidase like activity, but they also true catalysts. For CeO2 NPs, behavior observed for both oxidase- phosphatase-like activities due adsorption reaction products. Moreover, single-atom discussed. Finally, few suggestions future research proposed.

Language: Английский

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Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(51)

Published: Oct. 17, 2022

Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer function mitochondria. Additionally, react with H2 O produce large amount , which respectively lead enhanced PDT overload during mitochondrial damage, thereby triggering robust activation. Moreover, oxidative-damaged DNA, induced by released from cells, reprograms immunosuppressive transforming tumor-associated macrophages M1 subphenotype. shows that CCMH NIR-II elicit adequate DAMPs an active tumor-immune for both 4T1 CT26 models. Combining this method immune checkpoint blockade realize improved immunotherapy efficacy long-term protection effect body.

Language: Английский

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Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 5, 2023

Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is confirmed to activate the host immune system prevent, control, and eliminate tumors. Recently, a range chemotherapeutic drugs have been repurposed ICD inducers applied for tumor immunotherapy. However, several hurdles widespread application remain, namely poor water solubility, short blood circulation, non-specific tissue distribution, severe toxicity. Recent advances in nanotechnology pharmaceutical formulation foster development nano drug delivery systems tackle aforementioned expedite safe, effective, specific delivery. This review will describe barriers chemical highlight recent nanoformulations these

Language: Английский

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Mesoporous silica/organosilica nanoparticles for cancer immunotherapy

Exploration, Journal Year: 2023, Volume and Issue: 3(3)

Published: May 9, 2023

Cancer is one of the fatal diseases in history humankind. In this regard, cancer immunotherapeutic strategies have revolutionized traditional mode treatment. Silica based nano-platforms been extensively applied nanomedicine including immunotherapy. Mesoporous silica nanoparticles (MSN) and mesoporous organosilica (MON) are attractive candidates due to ease controlling structural parameters as needed for targeted applications. Especially, MON provide an additional advantage composition modulating biological functions actively synergize with other strategies. review, applications MSN, MON, metal-doped MSN/MON field immunotherapy tumor microenvironment regulation comprehensively summarized by highlighting compositional attributes silica-based nanoplatforms.

Language: Английский

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

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Genetically Edited Cascade Nanozymes for Cancer Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12295 - 12310

Published: May 2, 2024

Immune checkpoint blockade (ICB) has brought tremendous clinical progress, but its therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and infiltration cytotoxic T lymphocytes (CTLs). Evoking immunogenic cell death (ICD) is one promising strategy promote DC maturation elicit T-cell immunity, whereas low levels ICD induction solid tumors restrict durable antitumor efficacy. Herein, we report a genetically edited membrane-coated cascade nanozyme (gCM@MnAu) for enhanced cancer immunotherapy by inducing activating the stimulator interferon genes (STING) pathway. In tumor microenvironment (TME), gCM@MnAu initiates reaction generates abundant hydroxyl (•OH), resulting in improved chemodynamic therapy (CDT) boosted activation. addition, released Mn

Language: Английский

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Ultrasound-visible engineered bacteria for tumor chemo-immunotherapy

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(5), P. 101512 - 101512

Published: April 18, 2024

Our previous work developed acoustic response bacteria, which enable the precise tuning of transgene expression through ultrasound. However, it is still difficult to visualize these bacteria in order guide sound wave precisely irradiate them. Here, we develop ultrasound-visible engineered and chemically modify them with doxorubicin (DOX) on their surfaces. These (Ec@DIG-GVs) can produce gas vesicles (GVs), providing a real-time imaging for remote hyperthermia high-intensity focused ultrasound (hHIFU) induce interferon (IFN)-γ gene. The production IFN-γ kill tumor cells, macrophage polarization from M2 M1 phenotype, promote maturation dendritic cells. DOX be released acidic microenvironment, resulting immunogenic cell death concurrent effects activate tumor-specific T response, producing synergistic anti-tumor efficacy. study provides promising strategy bacteria-mediated chemo-immunotherapy.

Language: Английский

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Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Oct. 16, 2021

Abstract Chemodynamic therapy (CDT) catalyzed by transition metal and starvation intracellular metabolite oxidases are both classic tumor treatments based on nanocatalysts. CDT monotherapy has limitations including low catalytic efficiency of ions insufficient endogenous hydrogen peroxide (H 2 O ). Also, single shows limited ability resisting tumors. The “metal-oxidase” cascade system is to introduce into the metal-based nanoplatform, which perfectly solves shortcomings above-mentioned monotherapiesIn this system, can not only consume nutrients produce a “starvation effect”, but also provide with sufficient H suitable acidic environment, further promote synergy between therapy, leading enhanced antitumor effects. More importantly, be combined other therapies (such as photothermal hypoxia-activated drug chemotherapy, immunotherapy) maximize their In addition, nanoparticles activate immunity through multiple pathways, so combination immunotherapy powerful synergistic effect. This article firstly introduced metals induce then described in detail. Moreover, we highlight application numerous therapies, especially immunotherapy, expecting new ideas for treatment.

Language: Английский

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Phosphorous Dendron Micelles as a Nanomedicine Platform for Cooperative Tumor Chemoimmunotherapy via Synergistic Modulation of Immune Cells

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(3)

Published: Oct. 27, 2022

Design of effective nanomedicines to modulate multiple immune cells overcome the immune-suppressive tumor microenvironment is desirable improve overall poor clinical outcomes immunotherapy. Herein, a nanomedicine platform reported based on chemotherapeutic drug doxorubicin (DOX)-loaded phosphorus dendron micelles (M-G1-TBPNa@DOX, TBP, tyramine bearing two dimethylphosphonate) with inherent immunomodulatory activity for synergistic chemoimmunotherapy. The M-G1-TBPNa@DOX good stability and mean particle size 86.4 nm can deliver DOX solid tumors induce significant cell apoptosis immunogenic death (ICD). With demonstrated intrinsic M-G1-TBPNa that promote proliferation natural killer (NK) cells, ICD-resulted maturation dendritic DOX-loaded micelles, combination anti-PD-L1 antibody, modulation through NK proliferation, recruitment tumor-infiltrating cytotoxic T decrease regulatory chemoimmunotherapy strong antitumor immunity memory effect prevention lung metastasis are demonstrated. developed phosphorous may hold great promise be used as an advanced formulation different types.

Language: Английский

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