Nanoceria as an Electron Reservoir: Spontaneous Deposition of Metal Nanoparticles on Oxides and Their Anti-inflammatory Activities DOI
Faheem Muhammad,

Futao Huang,

Yuan Cheng

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 20567 - 20576

Published: Nov. 17, 2022

Designing metal–metal oxide heteronanostructures with synergistic and superior activities (unattainable in the case of a single entity) is great interest for wide range technological applications. Traditional synthetic strategies typically require reducing agents, stabilizing ligands, or high temperature reductive treatment to produce oxide-supported metals. Herein, facile noble metal deposition strategy developed silver, gold, platinum nanocrystals on surface hollow mesoporous cerium nanospheres without any pretreatment. Unlike galvanic replacement reaction, protocol employs innate potential CeO2 density ultrafine homogeneously immobilized onto nanospheres. The multienzyme-like (i.e., superoxide dismutase-like catalase-like) CeO2@metal nanostructures, originating from nanoparticles, were effectively utilized anti-inflammatory therapies two vivo models. This oxygen vacancy-mediated reduction can be generalized diverse nanostructures

Language: Английский

Nanozymes: Definition, Activity, and Mechanisms DOI Creative Commons
Mohamad Zandieh, Juewen Liu

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 17, 2023

Abstract “Nanozyme” is used to describe various catalysts from immobilized inorganic metal complexes, enzymes nanoparticles. Here, the history of nanozymes dvescribed in detail, and they can be largely separated into two types. Type 1 refer or on nanomaterials, which were dominant first decade since 2004. 2 nanozymes, rely surface catalytic properties are dominating type past decade. The definition evolving, a based same substrates products as able cover most currently claimed although may have different mechanisms compared their enzyme counterparts. A broader inspire application‐based research replace with nanomaterials for analytical, environmental, biomedical applications. Comparison also requires clear nanozyme unit. Four ways defining unit described, iron oxide horseradish peroxidase activity comparison examples each definition. Growing work devoted understanding mechanism provides basis further rational engineering active sites. Finally, future perspective field discussed.

Language: Английский

Citations

321
Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions DOI Creative Commons
Haijiao Dong, Wei Du, Jian Dong

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 12, 2022

As pioneering Fe

Language: Английский

Citations

257
Nanozyme-Enabled Analytical Chemistry DOI

Sirong Li,

Yihong Zhang, Quan Wang

et al.

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 94(1), P. 312 - 323

Published: Dec. 6, 2021

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNanozyme-Enabled Analytical ChemistrySirong LiSirong LiDepartment of Biomedical Engineering, College Engineering and Applied Sciences, Nanjing National Laboratory Microstructures, Jiangsu Key Artificial Functional Materials, University, Nanjing, 210023, ChinaMore by Sirong LiView Biography, Yihong ZhangYihong ZhangState Chemistry for Life Science, School Chemical Biomedicine Innovation Center (ChemBIC), ZhangView Quan WangQuan WangDepartment WangView Anqi LinAnqi LinDepartment LinView Hui Wei*Hui WeiDepartment ChinaState China*E-mail: [email protected]More WeiView Biographyhttps://orcid.org/0000-0003-0870-7142Cite this: Anal. Chem. 2022, 94, 1, 312–323Publication Date (Web):December 6, 2021Publication History Published online6 December 2021Published inissue 11 January 2022https://pubs.acs.org/doi/10.1021/acs.analchem.1c04492https://doi.org/10.1021/acs.analchem.1c04492review-articleACS PublicationsCopyright © 2021 American SocietyRequest reuse permissionsArticle Views8121Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting SUBJECTS:Carbohydrates,Chemical specificity,Enzyme-linked immunosorbent assays,Metal organic frameworks,Peptides proteins Get e-Alerts

Language: Английский

Citations

188
Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma DOI Creative Commons

Shaofang Zhang,

Yonghui Li, Si Sun

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 12, 2022

Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but limited by insufficient non-selective activities. Herein, we developed single-atom of RhN

Language: Английский

Citations

180
How to Define a Nanozyme DOI
Anne Robert, Bernard Meunier

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 6956 - 6959

Published: May 6, 2022

Over the past 15 years, many articles have considered "nanozymes" as ferromagnetic nanoparticles having an "intrinsic peroxidase-like activity" in presence of hydrogen peroxide. However, definition and catalytic activity these nanozymes been questioned. The present Perspective reports main criteria that are essential to classify a nanoparticle nanozyme. It is important consider not all able generate hydroxyl radicals peroxide without can be registered nanozymes.

Language: Английский

Citations

151
Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay DOI
Huizhen Fan, Jia‐Jia Zheng, Jiaying Xie

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: April 22, 2023

Nanozymes have great potential to be used as an alternative natural enzymes in a variety of fields. However, low catalytic activity compared with limits their practical use. It is still challenging design nanozymes comparable counterparts terms the specific activity. In this study, surface engineering strategy employed improve Ru using charge-transferrable ligands such polystyrene sulfonate (PSS). PSS-modified nanozyme exhibits peroxidase-like up 2820 U mg

Language: Английский

Citations

115
Removal and Degradation of Microplastics Using the Magnetic and Nanozyme Activities of Bare Iron Oxide Nanoaggregates DOI
Mohamad Zandieh, Juewen Liu

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(47)

Published: Oct. 5, 2022

Removal and degradation of microplastics are often carried out separately. In this work, hydrophilic bare Fe3 O4 nanoaggregates allowed efficient removal the most common including high-density polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyethylene terephthalate. Full extraction was achieved using at 1 % mass microplastics. Hydrogen bonding is main force for adsorption . Unlike more commonly used hydrophobically modified nanoparticles, benefitted from peroxidase-like activity its exposed surface, enabling further catalytic with nearly 100 efficiency easy recovery

Language: Английский

Citations

85
Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes DOI
Jie Zhuang, Adam C. Midgley,

Yonghua Wei

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 26, 2023

Abstract Nanozymes are nanomaterials that exhibit enzyme‐like biomimicry. In combination with intrinsic characteristics of nanomaterials, nanozymes have broad applicability in materials science, chemical engineering, bioengineering, biochemistry, and disease theranostics. Recently, the heterogeneity published results has highlighted complexity diversity terms consistency catalytic capacity. Machine learning (ML) shows promising potential for discovering new materials, yet it remains challenging design based on ML approaches. Alternatively, is employed to promote optimization intelligent application engineered enzymes. Incorporation successful algorithms used enzymes can concomitantly facilitate guided development next‐generation desirable properties. Here, recent progress ML, its utilization enzymes, how emergent applications serve as strategies circumvent challenges associated time‐expensive laborious testing nanozyme research summarized. The examples ML‐aided also highlighted, special focus unified aims enhancing recapitulation substrate selectivity activity.

Language: Английский

Citations

75
Nanozymes for nanohealthcare DOI
Yihong Zhang, Gen Wei, W. Liu

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: May 30, 2024

Language: Английский

Citations

68
Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications DOI
Kaizheng Feng, Guancheng Wang, Shi Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

Citations

62