Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

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Space-confined nanozyme with cascade reaction based on PCN-224 for synergistic bacterial infection treatment and NIR fluorescence imaging of wound bacterial infections

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150642 - 150642

Published: March 26, 2024

Language: Английский

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Au/Pt@ZIF-90 Nanoenzyme Capsule-Based “Explosive” Signal Amplifier for “All-in-Tube” POCT

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(3), P. 1362 - 1370

Published: Jan. 10, 2024

The sensitive, convenient, and visual detection of low-concentration disease markers in biological samples has always been a priority diagnosis. However, existing research problematic due to complex operation unsatisfactory sensitivity. Consequently, an "explosive" signal amplification platform based on Au/Pt@ZIF-90 was developed for sensitive markers. In this study, controllable explosively released Au/Pt nanoparticles (NPs) "nanoenzyme capsule" prepared by encapsulating NPs with excellent peroxidase activity ZIF-90. This achieved adjusting the particle size ZIF-90 encapsulation amount NPs. Using capsules as output module aptamer target recognition module, "All-in-Tube" portable point-of-care (POC) constructed integrating Au/Pt@ZIF-90/filter paper TMB/strips into Eppendorf (EP) tube. By utilizing specific competitive binding targets aptamers, enabled convenient measurement small molecular Taking adenosine proof concept, Moreover, can achieve universal various varying sequence. strategy provides design pattern holds significant potential fields diagnosis environmental monitoring.

Language: Английский

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Iridium nanoparticles supported on polyaniline nanotubes for peroxidase mimicking towards total antioxidant capacity assay of fruits and vegetables

Food Chemistry, Journal Year: 2024, Volume and Issue: 445, P. 138732 - 138732

Published: Feb. 13, 2024

Language: Английский

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Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 30, 2024

Language: Английский

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Core–Shell Structured Nanozyme with PDA-Mediated Enhanced Antioxidant Efficiency to Treat Early Intervertebral Disc Degeneration

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(4), P. 5103 - 5119

Published: Jan. 17, 2024

Early intervention during intervertebral disc degeneration (IDD) plays a vital role in inhibiting its deterioration and activating the regenerative process. Aiming at high oxidative stress (OS) IDD microenvironment, core–shell structured nanozyme composed of Co-doped NiO nanoparticle (CNO) as core encapsulated with polydopamine (PDA) shell, named PDA@CNO, was constructed, hoping to regulate pathological environment. The results indicated that coexistence abundant Ni3+/Ni2+and Co3+/Co2+redox couples CNO provided rich catalytic sites; meanwhile, quinone catechol groups PDA shell could enable proton-coupled electron transfer, thus endowing PDA@CNO multiple antioxidative enzyme-like activities scavenge •O2–, H2O2, •OH efficiently. Under OS conditions vitro, effectively reduce intracellular ROS nucleus pulposus (NP) into friendly H2O O2, protect NP cells from stagnant proliferation, abnormal metabolism (senescence, mitochondria dysfunction, impaired redox homeostasis), inflammation, thereby reconstructing extracellular matrix (ECM) homeostasis. vivo local injection experiments further proved desirable therapeutic effects rat model, suggesting great potential prohibiting deterioration.

Language: Английский

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New horizons for the therapeutic application of nanozymes in cancer treatment

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

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Dual-mode sensing platform based on aptamer-tunable catalytic activity of mesoporous polydopamine/MnO2 nanozymes for detecting S. aureus

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 393, P. 134218 - 134218

Published: June 28, 2023

Language: Английский

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Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

Inorganic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(15), P. 4289 - 4312

Published: Jan. 1, 2023

Single-atom nanozymes represent a unique class of enzyme mimics that exhibit maximal atomic utilization, well-defined electronic/geometric structure, and high catalytic activity, have found diverse applications in biomedicine biosensing.

Language: Английский

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Bioactive Metal–Organic Frameworks as a Distinctive Platform to Diagnosis and Treat Vascular Diseases

Small, Journal Year: 2024, Volume and Issue: 20(27)

Published: Feb. 5, 2024

Vascular diseases (VDs) pose the leading threat worldwide due to high morbidity and mortality. The detection of VDs is commonly dependent on individual signs, which limits accuracy timeliness therapies, especially for asymptomatic patients in clinical management. Therefore, more effective early diagnosis lesion-targeted treatments remain a pressing need. Metal-organic frameworks (MOFs) are porous crystalline materials formed by coordination inorganic metal ions organic ligands. Due their unique specific surface area, structural flexibility, functional versatility, MOFs recognized as highly promising candidates diagnostic therapeutic applications field VDs. In this review, potential act biosensors, contrast agents, artificial nanozymes, multifunctional agents treatment from perspective, highlighting integration between methods with generalized. At same time, multidisciplinary cooperation chemistry, physics, biology, medicine promote substantial commercial transformation tackling called for.

Language: Английский

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