Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123142 - 123142
Published: Dec. 16, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155131 - 155131
Published: Aug. 24, 2024
Language: Английский
Citations
13
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101502 - 101502
Published: Jan. 19, 2025
DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These facilitate the formation of spatial structures through bulk hydrogel fabricating, microsphere formatting, 3D printing. Furthermore, microenvironment can be finely tuned by leveraging degradation products, nanostructure, targeting, delivery capabilities inherent materials. In this review, we underscore advantages hydrogels, detailing composition, gelation techniques, structure optimization. We then delineate three critical elements in promotion using hydrogels: (i) osteogenesis driven phosphate ions, plasmids, oligodeoxynucleotides (ODNs) that enhance mineralization promote gene protein expression; (ii) vascularization facilitated tetrahedral DNA nanostructures (TDNs) aptamers, which boosts expression targeted release; (iii) immunomodulation achieved loaded factors, TDNs, bound ions stimulate macrophage polarization exhibit antibacterial properties. With these properties, used construct organoids, providing an innovative tool disease modeling therapeutic applications tissue engineering. Finally, discuss current challenges future prospects, emphasizing potential impacts regenerative medicine.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159545 - 159545
Published: Jan. 13, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101604 - 101604
Published: Feb. 22, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Abstract Diabetes‐induced oxidative stress can lead to poor bone defect healing, severely affecting the quality of life for patients. Studies show that improving microenvironment and promoting formation effectively accelerate healing defects. However, traditional local drug delivery methods face various challenges during treatment process. Therefore, this study develops a novel hydrogel (HLBP) loaded with natural protein polysaccharides (LBP) extracted from goji berries, aiming enhance diabetic The is composed freeze‐dried polyvinyl alcohol (PVA) photocrosslinked poly (ethylene glycol) diacrylate (PEGDA). This exhibits excellent biocompatibility. Additionally, it demonstrates effective loading capacity LBP. LBP's bioactivity enables ROS scavenging promotes regeneration at sites. In vitro, experimental results HLBP significantly reduces levels enhances osteogenic differentiation ability cell viability human marrow mesenchymal stem cells. vivo studies using BKS‐db mice implantation defects achieves over 80% highlighting its strong potential. method avoids potential toxicity systemic administration site, providing new strategy treating
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12567 - 12567
Published: Nov. 22, 2024
Constructing scaffolds with the desired structures and functions is one of main goals tissue engineering. Three-dimensional (3D) bioprinting a promising technology that enables personalized fabrication devices regulated biological mechanical characteristics similar to natural tissues/organs. To date, 3D has been widely explored for biomedical applications like engineering, drug delivery, screening, in vitro disease model construction. Among different bioinks, photocrosslinkable bioinks have emerged as powerful choice advanced devices, fast crosslinking speed, high resolution, great print fidelity. The biomaterials used light-based printing play pivotal role functional constructs. Herein, this review outlines general approaches related biomaterials, including extrusion-based printing, inkjet stereolithography laser-assisted printing. Further, mechanisms, advantages, limitations photopolymerization photoinitiators are discussed. Next, recent advances synthetic highlighted. Finally, challenges future perspectives envisaged.
Language: Английский
Citations
3
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 182 - 207
Published: Dec. 12, 2024
The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.
Language: Английский
Citations
1
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123142 - 123142
Published: Dec. 16, 2024
Language: Английский
Citations
0