Advances of hafnium based nanomaterials for cancer theranostics DOI Creative Commons
Jiayi Wang,

Jiahua Pan,

Yijun Tang

et al.

Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 24, 2023

Hafnium-based nanomaterials (Hf-NMs) have attracted the interest of numerous biomedical researchers by their unique properties. Recent years witnessed significant advancements in field nanomaterials, particularly context cancer diagnosis and treatment. However, research this area, especially concerning clinical application has not been thoroughly reviewed. This review will cover: 1) Classification synthesis including Hafnium oxide Metal-Organic Frameworks/nanoscale coordination polymers (MOFs/NCPs); 2) act as contrast enhancement agent for imaging, hafnium-based used liquid biopsy; 3) therapy, radiotherapy, photodynamic various combined therapy; 4) Translation, toxicity, safety Hf-NMs human preclinical animal models. More attention be given to translation cancer.

Language: Английский

First-generation clinical dual-source photon-counting CT: ultra-low-dose quantitative spectral imaging DOI
Leening P. Liu, Nadav Shapira, Andrew A. Chen

et al.

European Radiology, Journal Year: 2022, Volume and Issue: 32(12), P. 8579 - 8587

Published: June 16, 2022

Language: Английский

Citations

48
Metal Nanoparticles as Novel Agents for Lung Cancer Diagnosis and Therapy DOI

Xinjie Zheng,

Yuan Wu, Huali Zuo

et al.

Small, Journal Year: 2023, Volume and Issue: 19(18)

Published: Feb. 2, 2023

Abstract Lung cancer is one of the most common malignancies worldwide and contributes to cancer‐related morbidity mortality cases. During past decades, rapid development nanotechnology has provided opportunities challenges for lung diagnosis therapeutics. As extensively studied nanostructures, metal nanoparticles obtain higher satisfaction in biomedical applications associated with cancer. Metal have enhanced almost all major imaging strategies proved great potential as sensor detecting cancer‐specific biomarkers. Moreover, could also improve therapeutic efficiency via better drug delivery, improved radiotherapy, gene silencing, facilitated photo‐driven treatment. Herein, recently advanced applied therapy are summarized. Future perspective on direction metal‐based nanomedicine discussed. Stimulating more research interests promote devoted.

Language: Английский

Citations

36
CT and X-ray contrast agents: Current clinical challenges and the future of contrast DOI Creative Commons

Tyler C. Owens,

Nicolas Anton, Mohamed F. Attia

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 171, P. 19 - 36

Published: Sept. 20, 2023

Language: Английский

Citations

36
Nanostructures and nanoparticles as medical diagnostic imaging contrast agents: A review DOI
Nikiwe Mhlanga,

Ntsoaki Mphuthi,

Hendriëtte Van der Walt

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102233 - 102233

Published: Aug. 5, 2024

Language: Английский

Citations

13
Recent Advances in Stimuli-Responsive Self-Immolative Polymers for Drug Delivery and Molecular Imaging DOI
Yuce Li,

Jixiu Liu,

Jing He

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(9), P. 4054 - 4077

Published: April 18, 2024

Stimuli-responsive self-immolative polymers (SIPs) represent a unique class of that can undergo controlled, sequential head-to-tail depolymerization upon specific stimuli. Since their inception, they have evolved over two decades to become one the most attractive polymer types. With characteristic feature "one stimulus, multiple responses", SIPs inherently possess ability serve as chemical amplifiers, which amplify weak or biological signals. This promises higher stimulus sensitivity, greater selectivity for microenvironments, and potential generate more persistent, extensive, significant responses while consuming fewer stimuli sources. Review summarizes latest research advancements in stimuli-responsive drug delivery molecular imaging past five years. Regarding structure SIPs, we briefly overview updates self-immolation units, end-cap moieties, sequence SIPs. In terms applications, focus on possible applications disease treatment methods. Finally, provide brief perspective future directions these applications.

Language: Английский

Citations

10
Silver chalcogenide nanoparticles: a review of their biomedical applications DOI
Lenitza M. Nieves, Katherine J. Mossburg, Jessica C. Hsu

et al.

Nanoscale, Journal Year: 2021, Volume and Issue: 13(46), P. 19306 - 19323

Published: Jan. 1, 2021

Silver chalcogenide (Ag 2 X, where X = S, Se, or Te) nanoparticles have been extensively investigated for their applications in electronics but only recently explored biomedical applications.

Language: Английский

Citations

46
Simulating human gastrointestinal motility in dynamic in vitro models DOI Creative Commons
Yiwen Li, Fanbin Kong

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2022, Volume and Issue: 21(5), P. 3804 - 3833

Published: July 26, 2022

The application of dynamic in vitro gastrointestinal (GI) models has grown popularity to understand the impact food structure and composition on human health. Given that GI motility is integral digestion absorption, a predictive model should faithfully replicate patterns motor functions vivo. In this review, typical characteristics gastric small intestinal humans as well biomechanical hydrodynamic events pertinent gut are summarized. simulation presently existing discussed from an engineering perspective categorized into hydraulic, piston/probe-driven, roller-driven, pneumatic, other systems. Each system its representative evaluated terms their patterns, key concerning motility, performance simulating physiological events, ability establish vitro-in vivo correlations. Practical Application: review paper provided useful information design which important for understanding

Language: Английский

Citations

38
Spectral computed tomography with inorganic nanomaterials: State-of-the-art DOI
Yuhan Li, Muhsin H. Younis, Han Wang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114524 - 114524

Published: Sept. 2, 2022

Language: Английский

Citations

36
Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective DOI Creative Commons

Ning-ning Yue,

Haoming Xu,

Jing Xu

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4143 - 4170

Published: July 1, 2023

Abstract: The diagnosis of gastrointestinal (GI) diseases currently relies primarily on invasive procedures like digestive endoscopy. However, these can cause discomfort, respiratory issues, and bacterial infections in patients, both during after the examination. In recent years, nanomedicine has emerged as a promising field, providing significant advancements diagnostic techniques. Nanoprobes, particular, offer distinct advantages, such high specificity sensitivity detecting GI diseases. Integration nanoprobes with advanced imaging techniques, nuclear magnetic resonance, optical fluorescence imaging, tomography, correlation significantly enhanced detection capabilities for tumors inflammatory bowel disease (IBD). This synergy enables early precise staging disorders. Among nanoparticles investigated clinical applications, superparamagnetic iron oxide, quantum dots, single carbon nanotubes, nanocages have extensively studied utilized agents. review aimed to provide insights into potential applications modern specific focus their role facilitating range disorders, including IBD colorectal cancer (CRC). Additionally, we discussed challenges associated implementation nanotechnology-based diagnostics explored future prospects translation this field. Keywords: nano-diagnostics, gastroenterology, tumor,

Language: Английский

Citations

17
Size- and Shape-Dependent Interactions of Lipid-Coated Silver Nanoparticles: An Improved Mechanistic Understanding through Model Cell Membranes and In Vivo Toxicity DOI

Citlali Nieves Lira,

Andrew P. Carpenter, Joe E. Baio

et al.

Chemical Research in Toxicology, Journal Year: 2024, Volume and Issue: 37(6), P. 968 - 980

Published: May 14, 2024

The widespread use of silver nanoparticles (AgNPs) in various applications and industries has brought to light the need for understanding complex relationship between physicochemical properties (shape, size, charge, surface chemistry) AgNPs that affect their ability enter cells cause toxicity. To evaluate toxicological outcomes, this study systematically analyzed a series homogeneous hybrid lipid-coated spanning sizes from 5 100 nm with diverse shapes (spheres, triangles, cubes). lipid membrane comprises hydrogenated phosphatidylcholine (HPC), sodium oleate (SOA), hexanethiol (HT), which shield AgNP oxidation toxic Ag+ ion release minimize its contribution reduce any significant effects by chemistry, HPC, SOA, HT composition ratio was kept constant, were assessed using embryonic zebrafish (Danio rerio). While direct comparison cannot be drawn due lack complementary below 40 triangular plates cubes synthetic challenges, mortality observed spherical (AgNSs) 5, 20, 40, 60 at 120 h postfertilization concentrations ≥6 mg Ag/L. In contrast, 10, 80, AgNSs, 70, plate (AgNPLs), 55, 75, cubic (AgNCs) showed no days following exposure up 12 With constant chemistry on AgNPs, size is dominant factor driving responses, smaller (5 nm) being most toxic. Larger AgNCs, AgNPLs 75 do not show evidence However, when closely examining AgNPLs, there discriminates shape as driver toxicity since sublethal responses generally follow pattern, suggesting AgNSs followed then least Sum frequency generation vibrational spectroscopy irrespective or shape, all interact surfaces "snorkel" phases into monolayer minimal energetic cost. These findings decisively demonstrate only but also influences biological compatibility.

Language: Английский

Citations

6