Theranostics,
Journal Year:
2023,
Volume and Issue:
13(12), P. 4138 - 4165
Published: Jan. 1, 2023
Neurodegenerative
diseases
are
characterized
by
the
progressive
loss
of
neurons
and
intricate
interactions
between
different
cell
types
within
affected
regions.Reliable
biomarkers
that
can
accurately
reflect
disease
activity,
diagnose,
monitor
progression
neurodegenerative
crucial
for
development
effective
therapies.However,
identifying
suitable
has
been
challenging
due
to
heterogeneous
nature
these
diseases,
affecting
specific
subsets
in
brain
regions.One
promising
approach
promoting
regeneration
recovery
involves
transplantation
mesenchymal
stem
cells
(MSCs).MSCs
have
demonstrated
ability
modulate
immune
system,
promote
neurite
outgrowth,
stimulate
angiogenesis,
repair
damaged
tissues,
partially
through
release
their
extracellular
vesicles
(EVs).MSC-derived
EVs
retain
some
therapeutic
characteristics
parent
MSCs,
including
regulate
facilitate
tissue
repair.This
review
aims
explore
potential
MSC-derived
as
an
emerging
strategy
highlighting
role
modulating
neuronal
recovery.By
elucidating
mechanisms
which
exert
effects,
we
advance
our
understanding
leverage
novel
treatment
approaches
field
diseases.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: June 29, 2023
Dementia
is
a
growing
public
health
concern,
with
an
estimated
prevalence
of
57
million
adults
worldwide.
Alzheimer’s
disease
(AD)
accounts
for
60–80%
the
cases.
Clinical
trials
testing
potential
drugs
and
neuroprotective
agents
have
proven
futile,
currently
approved
only
provide
symptomatic
benefits.
Emerging
epidemiological
clinical
studies
suggest
that
lifestyle
changes,
including
diet
physical
activity,
offer
alternative
therapeutic
route
slowing
preventing
cognitive
decline
dementia.
Age
single
most
common
risk
factor
dementia,
it
associated
cellular
bioenergetics
metabolic
processes.
Therefore,
nutrient-rich
critical
optimal
brain
health.
Furthermore,
type
2
diabetes
(T2D)
AD,
diets
reduce
T2D
may
confer
neuroprotection.
Foods
predominant
in
Mediterranean,
MIND,
DASH
diets,
fruits,
leafy
green
vegetables,
fish,
nuts,
olive
oil,
prevent
or
slow
decline.
The
mechanisms
by
which
these
nutrients
promote
health,
however,
are
not
yet
completely
understood.
Other
dietary
approaches
eating
regimes,
ketogenic
intermittent
fasting,
also
emerging
as
beneficial
This
review
summarizes
pathophysiology,
factors,
pathways
activated
several
regimes
shown
promising
results
promoting
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2169 - 2169
Published: Feb. 11, 2024
Degenerative
diseases,
encompassing
a
wide
range
of
conditions
affecting
various
organ
systems,
pose
significant
challenges
to
global
healthcare
systems.
This
comprehensive
review
explores
the
intricate
interplay
between
vascular
system
and
degenerative
shedding
light
on
underlying
mechanisms
profound
implications
for
disease
progression
management.
The
pivotal
role
in
maintaining
tissue
homeostasis
is
highlighted,
as
it
serves
conduit
oxygen,
nutrients,
immune
cells
vital
organs
tissues.
Due
homeostasis,
its
dysfunction,
characterized
by
impaired
blood
flow,
endothelial
inflammation,
emerges
common
denominator
diseases
across
multiple
In
nervous
system,
we
explored
influence
factors
neurodegenerative
such
Alzheimer’s
Parkinson’s,
emphasizing
critical
cerebral
flow
regulation
blood–brain
barrier.
Within
kidney
relationship
health
chronic
scrutinized,
unraveling
which
hypertension
other
contribute
renal
dysfunction.
Throughout
this
review,
emphasize
clinical
significance
understanding
involvement
potential
therapeutic
interventions
targeting
health,
highlighting
emerging
treatments
prevention
strategies.
conclusion,
appreciation
essential
advancing
our
pathogenesis
developing
innovative
approaches
treatment.
provides
foundation
researchers,
clinicians,
policymakers
seeking
address
pursuit
improved
patient
outcomes
enhanced
public
health.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(6), P. 2993 - 3019
Published: April 10, 2024
Abstract
Neurodegenerative
disorders
(NDs)
are
among
the
most
common
causes
of
death
across
globe.
NDs
characterized
by
progressive
damage
to
CNS
neurons,
leading
defects
in
specific
brain
functions
such
as
memory,
cognition,
and
movement.
The
Parkinson's,
Alzheimer's,
Huntington's,
amyotrophic
lateral
sclerosis
(ALS).
Despite
extensive
research,
no
therapeutics
or
medications
against
have
been
proven
be
effective.
current
treatment
involving
symptom‐based
targeting
disease
pathogenesis
has
certain
limitations,
drug
resistance,
adverse
side
effects,
poor
blood–brain
barrier
permeability,
bioavailability
drugs.
Some
studies
shown
that
plant‐derived
natural
compounds
hold
tremendous
promise
for
treating
preventing
NDs.
Therefore,
primary
objective
this
review
article
is
critically
analyze
properties
potency
some
studied
phytomedicines,
quercetin,
curcumin,
epigallocatechin
gallate
(EGCG),
apigenin,
cannabinoids,
highlight
their
advantages
limitations
developing
next‐generation
alternative
treatments
Further
research
on
pre‐clinical
clinical
plant‐based
drugs
from
bench
bedside
warranted.
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: Feb. 28, 2025
This
review
aimed
to
elucidate
the
mechanisms
through
which
(i)
physical
activity
(PA)
enhances
neuroplasticity
and
cognitive
function
in
neurodegenerative
disorders,
(ii)
identify
specific
PA
interventions
for
improving
rehabilitation
programs.
We
conducted
a
literature
search
PubMed,
Medline,
Scopus,
Web
of
Science,
PsycINFO,
covering
publications
from
January
1990
August
2024.
The
strategy
employed
key
terms
related
neuroplasticity,
exercise,
function,
personalized
activity.
Inclusion
criteria
included
original
research
on
relationship
between
while
exclusion
eliminated
studies
focusing
solely
pharmacological
interventions.
identified
multiple
pathways
may
enhance
including
releasing
neurotrophic
factors,
modulation
neuroinflammation,
reduction
oxidative
stress,
enhancement
synaptic
connectivity
neurogenesis.
Aerobic
exercise
was
found
increase
hippocampal
volume
by
1–2%
improve
executive
scores
5–10%
older
adults.
Resistance
training
enhanced
control
memory
performance
12–18%
elderly
individuals.
Mind–body
exercises,
such
as
yoga
tai-chi,
improved
gray
matter
density
memory-related
brain
regions
3–5%
emotional
regulation
15–20%.
Dual-task
attention
processing
speed
8–14%
individuals
with
disorders.
also
discuss
potential
role
AI-based
AI
preventing
rehabilitating
illnesses,
highlighting
innovative
approaches
patient
outcomes.
significantly
disorders
various
mechanisms.
resistance
training,
mind–body
practices,
dual-task
exercises
each
offer
unique
benefits.
Implementing
these
activities
clinical
settings
can
Future
should
focus
creating
tailored
conditions,
incorporating
programs
optimize
rehabilitation.
Acta Neuropathologica Communications,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Feb. 15, 2024
Neurovascular
unit
mural
cells
called
'pericytes'
maintain
the
blood-brain
barrier
and
local
cerebral
blood
flow.
Pathological
changes
in
hippocampus
predispose
to
cognitive
impairment
dementia.
The
role
of
hippocampal
pericytes
dementia
is
largely
unknown.
We
investigated
90
post-mortem
brains
from
post-stroke
(PSD),
vascular
(VaD),
Alzheimer's
disease
(AD),
AD-VaD
(Mixed)
subjects,
non-demented
survivors
as
well
similar
age
controls.
used
collagen
IV
immunohistochemistry
determine
pericyte
densities
a
mouse
model
VaD
validate
effects
chronic
hypoperfusion.
Despite
increased
trends
microvascular
across
all
dementias,
mean
were
reduced
by
~25-40%
PSD,
AD
subjects
compared
those
controls,
which
calculated
14.1
±
0.7
per
mm
capillary
length,
specifically
cornu
ammonis
(CA)
1
region
(P
=
0.01).
In
mice
with
bilateral
carotid
artery
occlusion,
loss
was
~60%
relative
controls
<
0.001).
Pericyte
correlated
CA1
volumes
(r
0.54,
P
0.006)
but
not
any
other
sub-region.
However,
subjected
full-time
environmental
enrichment
(EE)
paradigm
showed
remarkable
attenuation
tandem
atrophy.
Our
results
suggest
common
dementias
explained
aetiology,
whilst
EE
offers
significant
protection.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(7), P. 2065 - 2065
Published: April 2, 2024
This
comprehensive
review
explores
the
dynamic
relationship
between
sports,
nutrition,
and
neurological
health.
Focusing
on
recent
clinical
advancements,
it
examines
how
physical
activity
dietary
practices
influence
prevention,
treatment,
rehabilitation
of
various
conditions.
The
highlights
role
neuroimaging
in
understanding
these
interactions,
discusses
emerging
technologies
neurotherapeutic
interventions,
evaluates
efficacy
sports
nutritional
strategies
enhancing
recovery.
synthesis
current
knowledge
aims
to
provide
a
deeper
lifestyle
factors
can
be
integrated
into
improve
outcomes.
Neuropharmacology,
Journal Year:
2023,
Volume and Issue:
240, P. 109718 - 109718
Published: Sept. 27, 2023
Increased
longevity
is
often
associated
with
age-related
conditions.
The
most
common
neurodegenerative
disorders
in
the
older
population
are
Alzheimer's
disease
(AD)
and
Parkinson's
(PD),
progressive
neuronal
loss
leading
to
functional
cognitive
impairments.
Although
symptomatic
treatments
available,
there
currently
no
cure
for
these
Gut
dysbiosis
has
been
involved
pathogenesis
of
AD
PD,
thus
interventions
targeting
"gut-brain
axis"
could
potentially
prevent
or
delay
pathologies.
Recent
evidence
suggests
that
skeletal
muscle
gut
microbiota
can
affect
each
other
via
"gut-muscle
axis".
Importantly,
functions
PD
patients
significantly
benefit
from
physical
activity.
In
this
review,
we
aim
provide
a
comprehensive
picture
crosstalk
between
brain,
microbiota,
introducing
concept
"gut-muscle-brain
Moreover,
discuss
human
animal
studies
exploring
modulatory
role
exercise
probiotics
on
cognition
PD.
Collectively,
findings
presented
here
support
potential
benefits
activity
probiotic
supplementation
Further
will
be
needed
develop
targeted
multimodal
strategies,
including
lifestyle
changes,
course
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: Aug. 1, 2024
Abstract
Posttranslational
modifications
play
a
crucial
role
in
governing
cellular
functions
and
protein
behavior.
Researchers
have
implicated
dysregulated
posttranslational
misfolding,
which
results
cytotoxicity,
particularly
neurodegenerative
diseases
such
as
Alzheimer
disease,
Parkinson
Huntington
disease.
These
aberrant
cause
proteins
to
gather
certain
parts
of
the
brain
that
are
linked
development
diseases.
This
leads
neuronal
dysfunction
start
disease
symptoms.
Cognitive
decline
neurological
impairments
commonly
manifest
patients,
underscoring
urgency
comprehending
modifications’
impact
on
function
for
targeted
therapeutic
interventions.
review
elucidates
critical
link
between
specific
modifications,
focusing
Tau,
APP,
α‐synuclein,
Huntingtin
protein,
Parkin,
DJ‐1,
Drp1.
By
delineating
prominent
within
underscores
significance
understanding
interplay
among
these
modifications.
Emphasizing
10
key
abnormal
this
study
aims
provide
comprehensive
framework
investigating
holistically.
The
insights
presented
herein
shed
light
potential
avenues
aimed
at
modulating
mitigate
aggregation
retard
progression.
