Association between periodontitis and severity of COVID‐19 infection: A case–control study

Journal Of Clinical Periodontology, Journal Year: 2021, Volume and Issue: 48(4), P. 483 - 491

Published: Feb. 3, 2021

COVID-19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation also a main characteristic of periodontitis. Therefore, we investigated the association periodontitis complications.A case-control study was performed using national electronic health records State Qatar between February and July 2020. Cases were defined as patients who suffered complications (death, ICU admissions or assisted ventilation), controls discharged without major complications. Periodontal conditions assessed dental radiographs from same database. Associations COVID 19 analysed logistic regression models adjusted for demographic, medical behaviour factors.In total, 568 included. After adjusting potential confounders, complication including death (OR = 8.81, 95% CI 1.00-77.7), admission 3.54, 1.39-9.05) need ventilation 4.57, 1.19-17.4). Similarly, blood levels white cells, D-dimer C Reactive Protein significantly higher periodontitis.Periodontitis risk admission, patients, increased biomarkers linked to worse disease

Language: Английский

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Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Antioxidants, Journal Year: 2020, Volume and Issue: 9(8), P. 742 - 742

Published: Aug. 13, 2020

Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some these could have an antiviral action or be important modulating immune system defending cells from oxidative stress associated infection. This short review draws attention components citrus fruits, especially orange (Citrus sinensis), well known for its vitamin flavonoid content. flavonoids, hesperidin recently attracted researchers, because it binds key proteins Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several computational methods, independently applied by different showed that low binding energy, both “spike” protein, main protease transforms early virus (pp1a ppa1b) into complex responsible viral replication. The energy is lower than lopinavir, ritonavir, indinavir, suggesting perform effective action. Furthermore, ascorbic acid counteract cell damaging effects oxygen free radicals triggered infection inflammation. There discussion about preventive efficacy C, at dose achievable diet, but recent reviews suggest this substance can useful case strong burden caused disease. Computational methods laboratory studies support need undertake apposite preclinical, epidemiological, experimental benefits fruit prevention infectious diseases, including COVID-19.

Language: Английский

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Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2

Journal of Dental Research, Journal Year: 2020, Volume and Issue: 100(2), P. 124 - 132

Published: Oct. 22, 2020

The oral cavity, an essential part of the upper aerodigestive tract, is believed to play important role in pathogenicity and transmission SARS-CoV-2. identification targeted antiviral mouth rinses reduce salivary viral load would contribute reducing COVID-19 pandemic. While awaiting results significant clinical studies, which date do not exist, commercial availability leads us search among them for reagents that have specific properties with respect challenges facing this target were examined 7 found commercially available listed on ClinicalTrials.gov website: povidone-iodine, chlorhexidine, hydrogen peroxide, cyclodextrin, Citrox, cetylpyridinium chloride, oils. Because SARS-CoV-2 enveloped virus, many outer lipid membrane. Moreover, some can act capsid by denaturing proteins. Until now, there has been no scientific evidence recommend anti–SARS-CoV-2 effect control cavity. This critical review indicates current knowledge these likely improve trends status. finding a strong sign encourage research quality protocols are already literature.

Language: Английский

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Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: June 23, 2021

The human oral microbiome (HOM) is the second largest microbial community after gut and can impact onset progression of several localized systemic diseases, including those viral origin, especially for viruses entering body via oropharynx. However, this important aspect has not been clarified new pandemic coronavirus SARS-CoV-2, causing COVID-19 disease, despite it being one many respiratory having oropharynx as primary site replication. In particular, no data are available about non-bacterial components HOM (fungi, viruses), which instead shown to be crucial other diseases. Consistent with this, study aimed define in patients, evidence any association between its profile clinical disease. Seventy-five rinse samples were analyzed by Whole Genome Sequencing (WGS) simultaneously identify bacteria, fungi, viruses. To correlate local virus replication, SARS-CoV-2 amount cavity was quantified digital droplet PCR. Moreover, inflammation secretory immune response also assessed, respectively measuring release pro-inflammatory cytokines (L-6, IL-17, TNFα, GM-CSF) production immunoglobulins A (sIgA). results showed presence dysbiosis patients compared matched controls, significantly decreased alpha-diversity value lower species richness subjects. Notably, correlated symptom severity ( p = 0.006), increased < 0.01). parallel, a mucosal sIgA observed more severely symptomatic 0.02), suggesting that early control infection correct development influenced profile. conclusion, presented here suggest may defining individual susceptibility infection, facilitating or rather, inducing protective IgA response. Although possible determine whether alteration cause effect these parameters considered markers personalized therapy vaccine development.

Language: Английский

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A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2

Clinical Oral Investigations, Journal Year: 2020, Volume and Issue: 24(10), P. 3707 - 3713

Published: Sept. 2, 2020

SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk nosocomial infections SARS-CoV-2. In this context, preprocedural mouthrinses hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim study was to investigate effects a 1% mouthrinse on reducing load.Twelve out 98 initially screened hospitalized SARS-CoV-2-positive patients were included in study. Intraoral viral load determined RT-PCR baseline, whereupon had gargle mouth throat 20 mL for 30 s. After min, second examination performed RT-PCR. Furthermore, virus culture specimens exhibiting least 103 RNA copies/mL baseline.Ten 12 completed The led no significant reduction load. Replicating could only be one baseline specimen.A does not reduce subjects. However, did yield any indication infectivity detected copies.The recommendation procedures questionable thus should supported longer, but strict infection prevention regimens are paramount importance.German Clinical Trials Register (ref. DRKS00022484).

Language: Английский

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Covid‐19 and oral diseases: Crosstalk, synergy or association?

Reviews in Medical Virology, Journal Year: 2021, Volume and Issue: 31(6)

Published: March 1, 2021

Summary The coronavirus disease 2019 (Covid‐19) is a viral infection caused by severe acute respiratory syndrome 2 (SARS‐CoV‐2) that clinically affects multiple organs of the human body. Cells in oral cavity express entry receptor angiotensin‐converting enzyme allows replication and may cause tissue inflammation destruction. Recent studies have reported Covid‐19 patients present manifestations with clinical aspects. In this review, we aim to summarise main signs symptoms cavity, its possible association diseases, plausible underlying mechanisms hyperinflammation reflecting crosstalk between diseases. Ulcers, blisters, necrotising gingivitis, opportunistic coinfections, salivary gland alterations, white erythematous plaques gustatory dysfunction were most Covid‐19. general, lesions appear concomitant loss smell taste. Multiple reports show evidences necrotic/ulcerative gingiva, blisters hypergrowth pathogens. SARS‐CoV‐2 exhibits tropism for endothelial cells Covid‐19‐mediated endotheliitis can not only promote tissues but also facilitate virus spread. addition, elevated levels proinflammatory mediators infectious impair homeostasis delayed resolution. This suggests potential immune‐mediated pathways pathogenesis. Interestingly, few suggest recurrent herpetic higher bacterial growth subjects, indicating virus/bacteria interaction. Larger cohort comparing negative positive subjects will reveal manifestation on health role exacerbating infection.

Language: Английский

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SARS-CoV-2 and Oral Manifestation: An Observational, Human Study

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(10), P. 3218 - 3218

Published: Oct. 7, 2020

The correlation between SARS-CoV-2 and oral manifestations is still controversial. aim of this observational study was to determine the manifestation hospitalized patients for COVID-19. A total 20 met inclusion criteria gave their signed informed consent. questionnaire 32 questions regarding systemic health condition administrated these during convalescence. descriptive statistic performed. Data were analysed through use χ2 test, assess statistical significance. statistically significant increase about 30% reporting xerostomia hospitalization observed (p = 0.02). Meanwhile, a decrease hygiene hospitalization, even if non-statistically difference shown two time points (before after hospitalization). During period, 25% reported impaired taste, 15% burning sensation, 20% difficulty in swallowing. An interesting result that among conditions, hypertension 39% mostly female (62.5%). Further studies are necessary better understand symptoms new virus order faster detect its presence humans. Probably, multidisciplinary team following COVID-19 could be key importance treating disease.

Language: Английский

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Oral Manifestations in Patients with COVID-19: A 6-Month Update

Journal of Dental Research, Journal Year: 2021, Volume and Issue: 100(12), P. 1321 - 1329

Published: July 29, 2021

This is the first update of previously published living systematic review that summarized evidence on prevalence oral signs and symptoms in patients with COVID-19. Hitherto, 183 studies were included, reporting data from 64,876 COVID-19 worldwide. The overall taste disorders was 38% (95% CI = 22% to 56%, I 2 98%). Hypogeusia, dysgeusia, ageusia also evaluated by a meta-analysis, pooled 34% for hypogeusia, 33% 26% ageusia. Taste associated positive test (odds ratio [OR] 7.54, 95% 5.24 10.86, 93%, P < 0.00001), showing high certainty evidence. However, association between mild/moderate severity (OR 1.63, 1.33 1.99, 69%, 0.0001) female 1.77, 1.26 2.48, 79%, 0.001) presented low Xerostomia new feature this update, demonstrated 43% 36% 50%, 71%) Regarding mucosal lesions, most common clinical pattern aphthous like, followed herpes-like candidiasis, glossitis/depapillation/geographic tongue, parotitis, angular cheilitis. Oral lesions more frequent lips, palate, presenting miscellaneous aspects are likely represent coinfections. Therefore, reanalysis current suggests triad xerostomia, dysfunction, as manifestations these outcomes under discussion, will be necessary confirm their direct SARS-CoV-2 infection cavity.

Language: Английский

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In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial

Journal of Evidence Based Dental Practice, Journal Year: 2021, Volume and Issue: 21(3), P. 101584 - 101584

Published: April 28, 2021

Language: Английский

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Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review

Dentistry Journal, Journal Year: 2021, Volume and Issue: 9(3), P. 32 - 32

Published: March 11, 2021

Since the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, management disease 2019 (COVID-19) has been challenging for healthcare providers. The oral cavity is referred to as a target SARS-CoV-2. aim this study was review symptoms specific COVID-19 patients from point view symptom prevalence and pathogenesis speculate pathogenic mechanisms underlying them. Scientific articles were retrieved by searching PubMed/MEDLINE, Google Scholar, medRxiv, bioRxiv 3 February 2020 31 December 2020, they reviewed title, abstract, text relevance. literature search indicated that frequently present with gustatory dysfunction, xerostomia, mucosal lesions, while their likely vary country, age, gender, severity. Gustatory dysfunction xerostomia appear at an early stage SARS-CoV-2 infection last relatively long. One possible both attributed expression viral cellular entry-relevant receptors in taste cells salivary glands. Dental professionals who can first become aware associated will play more active role make greater contribution diagnosis prevention COVID-19.

Language: Английский

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