Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(8), P. 3829 - 3842
Published: July 6, 2023
Small
extracellular
vesicles
(sEVs)
are
produced
by
most
cells
and
play
an
important
role
in
cell-to-cell
communication
maintaining
cellular
homeostasis.
Their
ability
to
transfer
biological
cargo
target
makes
them
a
promising
tool
for
cancer
drug
delivery.
Advances
sEV
engineering,
EV
mimetics,
ligand-directed
targeting
have
improved
the
efficacy
of
anticancer
delivery
functionality.
EV-based
RNA
interference
hybrid
miRNA
also
been
extensively
used
various
preclinical
models.
Despite
these
developments,
gaps
still
exist
our
understanding
using
sEVs
treat
solid
tumor
malignancies
effectively.
This
article
provides
overview
last
five
years
research
its
current
status
efficient
targeted
elimination
cells,
which
could
advance
bring
formulations
into
clinical
use.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(18), P. 6624 - 6624
Published: Sept. 14, 2023
Knowing
the
beneficial
aspects
of
nanomedicine,
scientists
are
trying
to
harness
applications
nanotechnology
in
diagnosis,
treatment,
and
prevention
diseases.
There
also
potential
uses
designing
medical
tools
processes
for
new
generation
scientists.
The
main
objective
conducting
this
research
review
is
gather
widespread
nanomedicine
under
one
heading
highlight
standard
practices
field.
Comprehensive
has
been
conducted
incorporate
latest
data
related
medicine
therapeutics
derived
from
acknowledged
scientific
platforms.
Nanotechnology
used
conduct
sensitive
procedures.
showing
successful
fields
diagnostics,
disease
regenerative
medicine,
gene
therapy,
dentistry,
oncology,
aesthetics
industry,
drug
delivery,
therapeutics.
A
thorough
association
cooperation
between
physicians,
clinicians,
researchers,
technologies
will
bring
forward
a
future
where
there
more
calculated,
outlined,
technically
programed
field
nanomedicine.
Advances
being
made
overcome
challenges
associated
with
application
due
pathophysiological
basis
This
highlights
multipronged
how
proving
health
industry.
need
minimize
health,
environmental,
ethical
concerns
linked
nanotechnology.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2345 - 2345
Published: Sept. 19, 2023
Many
active
pharmaceutical
ingredients
show
low
oral
bioavailability
due
to
factors
such
as
poor
solubility
and
physical
chemical
instability.
The
formation
of
inclusion
complexes
with
cyclodextrins,
well
cyclodextrin-based
polymers,
nanosponges,
nanofibers,
is
a
valuable
tool
improve
the
many
drugs.
microencapsulation
process
modifies
key
properties
included
drugs
including
volatility,
dissolution
rate,
bioavailability,
bioactivity.
In
this
context,
we
present
relevant
examples
stabilization
labile
through
encapsulation
in
cyclodextrins.
belonging
class
IV
biopharmaceutical
classification
system
an
effective
solution
increase
their
also
discussed.
improvement
nutraceuticals
used
food
supplements,
which
often
have
intestinal
absorption
solubility,
considered.
Cyclodextrin-based
are
polymer-free
can
be
generated
using
environmentally
friendly
technologies,
lead
dramatic
enhancements.
synthesis
chemically
modified
nanosponges
based
on
cyclodextrins
Analytical
techniques
that
allow
characterization
verification
true
considered,
taking
into
account
differences
procedures
for
solid
state.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 7, 2025
Nanocarriers
are
transport
and
encapsulation
systems
that
primarily
serve
to
protect
improve
the
dispersibility
of
predominantly
hydrophobic
active
ingredients
but
also
enable
their
targeted
delivery
controlled
release
at
site
action.
mainly
made
either
organic
or
inorganic
materials,
various
combinations
materials
in
complex
structures
under
development.
Most
nanocarriers
represent
entities
rationally
designed
meet
functional
requirements
a
specific
application.
They
can
therefore
be
understood
as
Advanced
Materials.
Nanocarrier
already
being
used
medicine,
cosmetics,
agriculture,
food,
household
products.
variety
products,
ideally
safe
sustainable,
may
need
registered
before
they
placed
on
market.
Inspired
by
medical
research,
increasingly
for
precision
farming
(nano-agrochemicals)
such
air
fresheners
lithium-ion
batteries,
could
thus
released
into
environment
large
quantities.
To
identification
critical
subsequent
investigations,
comprehensive
literature
review
broad
heterogeneous
research
field
is
provided,
well
an
approach
categorization
based
origin
chemical
composition
constituent
materials.
A
definition
size
(1–1000
nm)
function
proposed
risk
assessment.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(7)
Published: Oct. 31, 2023
Abstract
Nanosponges
are
unique
sponge‐like
carrier
systems
with
numerous
cavities
and
a
mesh‐like
network
throughout
their
surface.
They
categorized
into
three
types
based
on
the
material
of
construction,
i.e.,
polymer‐,
inorganic‐,
bio‐derived
material‐based
nanosponges.
Unlike
conventional
nanoparticles,
nanosponges
bear
countless
interconnected
voids
that
enables
maximum
drug,
imaging
probe,
or
photosensitizer
loading
via
absorption,
encapsulation,
conjugation,
complexion.
The
can
be
further
sealed
using
suitable
lipids
polymers
to
avoid
leakage
drugs
at
non‐target
site,
protect
therapeutics
from
biological
conditions,
control
release
for
prolonged
period.
Recently,
have
grasped
attention
researchers
in
area
cancer
by
overcoming
drawbacks
associated
delivery
immunotherapeutic,
targeted
therapeutic,
chemotherapeutic
agents.
Interestingly,
several
reports
also
witnessed
potential
theranostics.
Owing
this
supremacy,
could
an
apt
platform
therapy
diagnosis.
current
review
discusses
general
aspects,
types,
preparation
methods
In
addition,
ambit
treating
different
is
meticulously
discussed,
along
detailed
descriptions
corresponding
patents.
Furthermore,
role
phototherapy
theranostics
selectively
canvassed.
Heliyon,
Journal Year:
2023,
Volume and Issue:
10(1), P. e23303 - e23303
Published: Dec. 6, 2023
The
complicated
chemical
reactions
involved
in
the
production
of
newer
drug
delivery
systems
have
mainly
impeded
efforts
to
build
successful
targeted
for
a
prolonged
duration
time.
Nanosponges,
recently
created
colloidal
system,
potential
overcome
issues
with
medication
toxicity,
decreased
bioavailability,
and
release
over
wide
area
because
they
can
be
modified
work
both
hydrophilic
hydrophobic
types
drugs.
Nanosponges
are
small
sized
three-dimensional
network
having
porous
cavity.
They
prepared
easily
by
crosslinking
cyclodextrins
different
compounds.
Due
Cyclodextrin's
outstanding
biocompatibility,
stability,
safety,
number
Cyclodextrin-based
been
developed
promptly.
nanosponge
system
possesses
various
applications
ailments
such
as
cancer,
autoimmune
diseases,
theranostic
applications,
enhanced
etc.
This
review
elaborates
on
benefits
drawbacks,
preparation
techniques,
factors
affecting
their
preparation,
characterization
most
current
developments
nanosponges.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115512 - 115512
Published: Sept. 17, 2023
Sesamol
is
a
lignan
of
sesame
seeds
and
natural
phenolic
molecule
that
has
emerged
as
useful
medical
agent.
non-toxic
phytoconstituent,
which
exerts
certain
valuable
effects
in
the
management
cancer,
diabetes,
cardiovascular
diseases,
neurodegenerative
diseases
(NDs),
etc.
known
to
depict
its
neuroprotective
role
by
various
mechanisms,
such
metabolic
regulators,
action
on
oxidative
stress,
neuroinflammation,
However,
poor
oral
bioavailability,
rapid
excretion
(as
conjugates),
susceptibility
gastric
irritation/toxicity
(particularly
rats'
forestomach)
may
restrict
effectiveness.
To
overcome
associated
limitations,
novel
drug
delivery
system-based
formulations
sesamol
are
emerging
being
researched
extensively.
These
can
conjugate
with
enhance
bioavailability
solubility
free
sesamol,
along
at
target
site.
In
this
review,
we
have
summarized
research
works
highlighting
NDs,
including
Alzheimer's
disease,
Huntington's
Amyotrophic
lateral
sclerosis,
Parkinson's
disease.
Moreover,
formulation
strategies
sesamol-based
nano-formulations
also
been
discussed.
ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
6(9), P. 7123 - 7149
Published: April 25, 2023
Since
cancer
has
a
very
complex
pathophysiology,
existing
treatment
strategies
encounter
several
challenges
such
as
the
lack
of
specificity/selectivity,
induction
multidrug
resistance,
and
possible
side
effects/toxicity.
A
wide
variety
organic,
inorganic,
hybrid
nanosystems
have
been
designed
with
unique
magnetic,
thermal,
mechanical,
electrical,
optical
properties
for
targeted
therapy.
These
advanced
enhanced
bioavailability,
biocompatibility,
drug
loading
capacity
developed
therapy
to
reduce
toxicity
improve
targeting
properties.
In
this
context,
persist
their
clinical
translational
studies
enhancement
therapeutic
efficiency
well
optimization
synthesis
conditions
large-scale
production.
addition,
despite
promising
preclinical
results,
number
available
patients
is
still
low,
partly
due
understanding
differences
among
animal
model
species
humans
that
influence
behavior
functionality
these
nanosystems.
Regarding
this,
organ-on-a-chip
platforms
can
significantly
help
in
screening
delivery
aspects
cancer/tumor
cells
modeling
research;
organs-on-chip
approach
also
be
helpful
analyze
cancer–immune
interactions.
Future
should
focus
on
exploration
multifunctional
synergistic
chemo-photothermal,
photothermal/photodynamic,
immunotherapeutic
potentials
smart
theranostic
capabilities.
Herein,
recent
advancements
pertaining
applications
therapeutics
are
deliberated.
Current
obstacles
limitations
hindering
application
from
research
uses
discussed
while
providing
recommendations
more
efficient
adoption
nanomaterials
cancers.
Discover Nano,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: April 20, 2023
Abstract
Malaria
is
a
life-threatening,
blood-borne
disease
with
over
two
hundred
million
cases
throughout
the
world
and
more
prevalent
in
Sub-Saharan
Africa
than
anywhere
else
world.
Over
years,
several
treatment
agents
have
been
developed
for
malaria;
however,
most
of
these
active
pharmaceutical
ingredients
exhibit
poor
aqueous
solubility
low
bioavailability
may
result
drug-resistant
parasites,
thus
increasing
malaria
eventually,
deaths.
Factors
such
as
therapeutics
led
to
better
appreciation
nanomaterials.
The
ability
nanomaterials
function
drug
carriers
high
loading
capacity
targeted
delivery,
good
biocompatibility,
toxicity
renders
them
an
appealing
alternative
conventional
therapy.
Nanomaterials
dendrimers
liposomes
demonstrated
be
capable
enhancing
efficacy
antimalarial
drugs.
This
review
discusses
recent
development
their
benefits
delivery
potential
malaria.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1480 - 1480
Published: May 12, 2023
Fisetin
(FS)
is
considered
a
safer
phytomedicine
alternative
to
conventional
chemotherapeutics
for
breast
cancer
treatment.
Despite
its
surpassing
therapeutic
potential,
clinical
utility
hampered
by
low
systemic
bioavailability.
Accordingly,
as
far
we
are
aware,
this
the
first
study
develop
lactoferrin-coated
FS-loaded
β-cyclodextrin
nanosponges
(LF-FS-NS)
targeted
FS
delivery
cancer.
NS
formation
through
cross-linking
of
diphenyl
carbonate
was
confirmed
FTIR
and
XRD.
The
selected
LF-FS-NS
showed
good
colloidal
properties
(size
52.7
±
7.2
nm,
PDI
<
0.3,
ζ-potential
24
mV),
high
loading
efficiency
(96
0.3%),
sustained
drug
release
26
%
after
h.
Morphological
examination
using
SEM
revealed
mesoporous
spherical
structure
prepared
with
pore
diameter
~30
which
further
surface
area
measurement.
Additionally,
enhanced
oral
IP
bioavailability
(2.5-
3.2-fold,
respectively)
compared
suspension
in
rats.
Antitumor
efficacy
evaluation
vitro
on
MDA-MB-231
cells
vivo
an
Ehrlich
ascites
mouse
model
demonstrated
significantly
higher
activity
targetability
(30
mg/kg)
free
uncoated
formulation.
Consequently,
could
be
addressed
promising
formulation
effective
management
