Endocrine disruptors: Unravelling the link between chemical exposure and Women's reproductive health

Environmental Research, Journal Year: 2023, Volume and Issue: 241, P. 117385 - 117385

Published: Oct. 12, 2023

Language: Английский

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Adverse effects of triclosan exposure on health and potential molecular mechanisms

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 879, P. 163068 - 163068

Published: March 23, 2023

Language: Английский

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After effects of Pharmaceuticals and Personal Care Products (PPCPs) on the biosphere and their counteractive ways

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 342, P. 126921 - 126921

Published: Feb. 27, 2024

Language: Английский

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Triclosan: A Small Molecule with Controversial Roles

Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 735 - 735

Published: May 30, 2022

Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective controlling biofilm formation maintaining gingival health. Given its broad usage, TCS present ubiquitously the environment. strong lipophilicity accumulation ability organisms, it potentially harmful to biohealth. Several reports suggest toxicity of this compound, which inserted class endocrine disrupting chemicals (EDCs). In September 2016, was banned by U.S. Food Drug Administration (FDA) European Union soap products. Despite these problems, application products within certain limits still allowed. Today, unclear whether truly toxic mammals adverse effects continuous, long-term, low concentration exposure remain unknown. Indeed, some recent use as repositioned drug for cancer treatment cutaneous leishmaniasis. scenario necessary investigate advantages disadvantages understand advisable or not. This review intends highlight pros cons that are associated with humans.

Language: Английский

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Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Feb. 22, 2023

Abstract Background Triclosan [5-chloro-2-(2,4-dichlorophenoxy) phenol, TCS], a common antimicrobial additive in many personal care and health products, is frequently detected human blood urine. Therefore, it has been considered an emerging potentially toxic pollutant recent years. Long-term exposure to TCS suggested exert endocrine disruption effects, promote liver fibrogenesis tumorigenesis. This study was aimed at clarifying the underlying cellular molecular mechanisms of hepatotoxicity effect initiation stage. Methods C57BL/6 mice were exposed different dosages for 2 weeks organ toxicity evaluated by various measurements including complete count, histological analysis quantification. Single cell RNA sequencing (scRNA-seq) then carried out on TCS- or mock-treated mouse livers delineate TCS-induced hepatotoxicity. The acquired single-cell transcriptomic data analyzed from aspects differential gene expression, transcription factor (TF) regulatory network, pseudotime trajectory, communication, systematically dissect events after exposure. To verify fibrosis, expression levels key fibrogenic proteins examined Western blotting, immunofluorescence, Masson’s trichrome Sirius red staining. In addition, normal hepatocyte MIHA hepatic stellate LX-2 used as vitro models experimentally validate effects immunological, proteomic metabolomic technologies. Results We established relatively short term murine model found mainly accumulated liver. scRNA-seq performed TCS-treated control group profiled expressions > 76,000 cells belonging 13 major types. Among these types, hepatocytes (HSCs) significantly increased group. that promoted fibrosis-associated proliferation hepatocytes, which Gata2 Mef2c are driving TFs. Our also induced activation HSCs, verified both tissue model. other changes dysfunction capillarization endothelial cells, increase fibrotic characteristics B plasma M2 phenotype-skewing macrophage deduced analysis, likely contribute progression fibrosis. Lastly, ligand-receptor pairs involved communications identified we confirmed role GAS6_AXL interaction-mediated communication promoting Conclusions modulates activities fates several specific types (including Kupffer capsular macrophages) liver, regulates interactions between thereby leading Overall, provide first comprehensive atlas response processes

Language: Английский

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Triclosan and related compounds in the environment: Recent updates on sources, fates, distribution, analytical extraction, analysis, and removal techniques

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 870, P. 161885 - 161885

Published: Jan. 31, 2023

Language: Английский

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Efficient removal of triclosan from water through activated carbon adsorption and photodegradation processes

Environmental Research, Journal Year: 2024, Volume and Issue: 246, P. 118162 - 118162

Published: Jan. 11, 2024

Language: Английский

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Critical review on the environmental behaviors and toxicity of triclosan and its removal technologies

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 173013 - 173013

Published: May 7, 2024

Language: Английский

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Pulsed-Bed Column Adsorption for Triclosan Removal Using Macadamia Nut Shell Activated Carbon

Civil Engineering Journal, Journal Year: 2024, Volume and Issue: 10(5), P. 1645 - 1661

Published: May 1, 2024

Triclosan (TCS), a common antibacterial agent found in numerous personal care products, has been detected wastewater and surface water is now of significant environmental concern due to its health impacts. To mitigate this issue, various treatment methods have explored. This study investigated the efficacy Macadamia nut shell activated carbon (MAC) as an economical adsorbent for triclosan removal. A pulsed-bed column adsorption technique was applied enhance capacity prolong operational lifespan column. Batch experiments were conducted explore parameters capacity. Column carried out investigate breakthrough curves associated parameters. In batch experiments, MAC exhibited high TCS 119.05 mg/g, optimal conditions determined. Adsorption kinetics followed pseudo-second-order model, equilibrium data well-fitted by both Langmuir Freundlich isotherm models. showed superior performance compared fixed-bed under specific (flow rate: 10 mL/min, initial concentration: 60 mg/L, bed height: cm) removal height only 6 cm, successfully enhancing 53.40 mg/g extending 5,280 minutes. Adapting columns from product industry led extension life with increased minimized use adsorbents practical environmentally friendly method. Doi: 10.28991/CEJ-2024-010-05-019 Full Text: PDF

Language: Английский

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Multiresidue determination and predicted risk assessment of emerging contaminants in sediments from Kongsfjorden, Svalbard

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171156 - 171156

Published: Feb. 26, 2024

Language: Английский

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