The independent and interactive effects of heavy metal pollution and vitamin D deficiency on early kidney injury indicators: analysis of the National Health and Nutrition Examination Survey 2001–2004 DOI Creative Commons
Suoshi Jing,

Yuan Ge,

Jingju Pan

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Heavy metals (e.g., cadmium, lead, mercury, etc.) can infiltrate the human body via diverse routes, with a propensity to accumulate in kidney cortex, thereby precipitating dysfunction. Vitamin D has been implicated mitigating oxidative stress and inflammatory reactions triggered by heavy metal exposure. However, interplay between toxicity vitamin deficiency context of incipient injury remains an underexplored area research. Utilizing data from National Health Nutrition Examination Survey spanning 2001 2004, Our methodology leveraged spline smoothing within framework generalized additive models more vividly elucidate impact exposure serum levels on trajectory early biomarkers (including albumin-to-creatinine ratio, β-2 microglobulin (B2M), cystatin C (CYST), estimated glomerular filtration rate (eGFR) (serum creatinine(SCr)-based(eGFR), CYST-based eGFR, SCr-CYST-based eGFR). Furthermore, we conducted interaction analysis assess combined effects injury. The cohort comprised 2,422 adults. results indicated that cadmium were positively correlated B2M, CYST, negatively eGFRc, eGFRs. Similarly, lead showed positive correlation ACR, negative eGFRc&s. In contrast, mercury CYST eGFRc. addition, there was indicators (P for interaction: B2M: 0.028, CYST: 0.038, eGFRc&s: 0.011). This study suggests increased risk It highlights potential importance targeted supplementation reduction these findings warrant validation through further prospective

Language: Английский

Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies DOI Creative Commons

Jiayi Li,

Changming Guo,

Yan Liu

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution liver-microbiota-gut axis in chronic inorganic exposure-triggered biotoxicity chickens based on multi-omics technologies. Forty Hy-Line W-80 laying hens were chronically exposed sodium arsenite with dose-dependent manner (administered drinking water containing 10, 20, or 30 mg/L arsenic, respectively) 42 d, followed transcriptomics, serum non-targeted metabolome, 16S ribosomal RNA gene sequencing accordingly. intervention induced serious chicken liver dysfunction, especially severe fibrosis, simultaneously altered ileal microbiota populations, impaired intestinal barrier, further drove enterogenous lipopolysaccharides translocation via portal vein circulation aggravating damage. Furtherly, injured disturbed bile acids (BAs) homoeostasis through strongly up-regulating BAs synthesis key rate-limiting enzyme CYP7A1, inducing excessive total accumulation, accompanied massive primary BA—chenodeoxycholic acid. Moreover, concentrations secondary BAs—ursodeoxycholic acid lithocholic markedly repressed, which might involve repressed dehydroxylation Ruminococcaceae Lachnospiraceae families. Abnormal metabolism turn promoted injury, ultimately perpetuating pernicious circle chickens. Notably, obvious depletion abundance four profitable microbiota, Christensenellaceae, Ruminococcaceae, Muribaculaceae, Faecalibacterium, correlated tightly this hepato-intestinal process Our demonstrates that exposure evokes disruption establishes scientific basis evaluating risk environmental pollutant

Language: Английский

Citations

19
The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis DOI
Xue Yang,

Yi Fang,

Jianbo Hou

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 300, P. 134479 - 134479

Published: March 31, 2022

Language: Английский

Citations

63
Self-assembling fluorescent hydrogel for highly efficient water purification and photothermal conversion DOI
Meng Li, Mengqing Yang, Bowen Liu

et al.

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 431, P. 134245 - 134245

Published: Dec. 20, 2021

Language: Английский

Citations

58
Luteolin Protects Chondrocytes from H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating AMPK-Nrf2 Signaling DOI Creative Commons
Zhiqiang Zhou, Linlin Zhang, Liu Yang

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 20

Published: Feb. 1, 2022

Osteoarthritis (OA) is a chronic degenerative disease featured by cartilage erosion and inflammation. Luteolin, member of the flavonoid family, has been shown to exert anti-inflammatory antioxidative activities. However, potential biological effects underlying mechanism luteolin on chondrocytes OA progression remain largely elusive. In this study, effect were investigated in vitro vivo. Our data revealed that inhibited H2O2-induced cell death, apoptosis, oxidative stress, programmed necrosis, inflammatory mediator production primary murine chondrocytes. addition, could activate AMPK Nrf2 pathways, serves as positive upstream regulator Nrf2. vivo results demonstrated therapeutic DMM mouse model. Collectively, our findings showed might serve novel effective treatment for provided new research direction clinical therapies.

Language: Английский

Citations

42
Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails DOI
Biqi Han, Jiayi Li, Siyu Li

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 442, P. 130082 - 130082

Published: Sept. 30, 2022

Language: Английский

Citations

39
Recent advances in fluorescent materials for mercury(ii) ion detection DOI Creative Commons
Qiuping Li, You Zhou

RSC Advances, Journal Year: 2023, Volume and Issue: 13(28), P. 19429 - 19446

Published: Jan. 1, 2023

Based on the sensing mechanism, Hg 2+ ion materials developed in recent years were systematically discussed, classified into seven types, and their corresponding fluorescence mechanisms briefly introduced.

Language: Английский

Citations

37
Pollutants in aquatic system: a frontier perspective of emerging threat and strategies to solve the crisis for safe drinking water DOI

Saima Jan,

Awdhesh Kumar Mishra, Mujtaba Aamir Bhat

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(53), P. 113242 - 113279

Published: Oct. 21, 2023

Language: Английский

Citations

35
Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers DOI
Lu Yu,

Zhanjun Lv,

Siyu Li

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 890, P. 164172 - 164172

Published: May 16, 2023

Language: Английский

Citations

32
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway DOI Creative Commons

Jun Xu,

Luying Zhao,

Xiangting Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115331 - 115331

Published: Aug. 7, 2023

Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced liver injury. Ferroptosis is type programmed cell death mediated by iron-dependent lipid peroxidation. Endoplasmic reticulum (ER) stress systemic response triggered the accumulation unfolded or misfolded proteins in ER. and ER have proven to contribute progression APAP-induced acute injury (ALI). It was reported that salidroside protects against ALI, but potential mechanism remain unknown. In this study, male C57BL/6 J mice were intraperitoneally (i.p.) injected APAP (500 mg/kg) induce an ALI model. Salidroside i.p. at dose 100 mg/kg 2 h prior administration. Mice sacrificed 12 after injection serum obtained for histological biochemistry analysis. AML12 cells used vitro assays. The results indicated mitigated glutathione degradation via inhibiting cation transport regulator homolog 1 (CHAC1) attenuate ferroptosis, simultaneously suppressing PERK-eIF2α-ATF4 axis-mediated stress, thus alleviating ALI. However, PERK activator CCT020312 overexpression ATF4 inhibited protective function on CHAC1-mediated ferroptosis. Besides this, activation AMPK/SIRT1 signaling pathway demonstrated effect Interestingly, selective inhibition SIRT1 ameliorated effects Overall, plays significant part mitigation activating inhibit stress-mediated ferroptosis ATF4-CHAC1 axis.

Language: Английский

Citations

25
Mercury(II)-Triggered Targeted and NIR-II Fluorescence/Photoacoustic Imaging Probe for High-Sensitivity Early Diagnosis and Evaluating Drug against Acute Liver and Kidney Injury DOI
Xinyue Li, Zhongxia Duan, Zhi‐Wen Zhao

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Mercury ions (Hg2+) have been found to disrupt the body's antioxidant defense mechanisms, leading oxidative stress and physiological dysfunction. Early diagnosis real-time monitoring of Hg2+ fluctuations in organ damage are crucial but limited due lack noninvasive deep tissue imaging probes. Herein, a Hg2+-triggered targeted NIR-II fluorescence/photoacoustic (PA) dual-mode molecular probe (NHG-2) was developed for Hg2+-induced acute liver kidney injury mice. NHG-2 designed through rational adjustment conjugated ring structure further screening processes, enabling it sensitively recognize subsequently open mitochondrial targeting, producing fluorescence/PA signals. This allowed injury, demonstrating excellent detection sensitivity. Furthermore, can be utilized evaluate efficacy N-acetylcysteine (NAC) dual signal indication. Mechanism studies suggested that NAC activated Akt/Nrf2 signaling pathway, reversed changes related biomarkers, restored membrane potential. Thus, this study not only presents first specific also provides potential tool early treatment evaluation pathogenesis study.

Language: Английский

Citations

1