Spotlight on therapeutic efficiency of mesenchymal stem cells in viral infections with a focus on COVID-19

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 17, 2022

Abstract The SARS-COV-2 virus has infected the world at a very high rate by causing COVID-19 disease. Nearly 507 million individuals have been with this virus, approximately 1.2% of these patients being dead, indicating that out control in many countries. While researchers are investigating how to develop efficient drugs and vaccines versus pandemic, new superseded treatments potential reduce mortality. recent application mesenchymal stem cells (MSCs) subgroup acute respiratory distress created benefits as supportive therapy for viral contagion conditions aged severe pneumonia. Consequently, within overview, we discuss role therapeutic MSCs challenges ahead using them treat infections, highlighting on infection. Graphical

Language: Английский

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Circulating microRNAs as emerging regulators of COVID-19

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 125 - 147

Published: Nov. 29, 2022

Coronavirus disease 2019 , an infectious caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that has high incidence rates, spreads rapidly, and more than 6.5 million deaths globally to date.Currently, several drugs have been used in clinical treatment of COVID-19, including antivirals (e.g., molnupiravir, baricitinib, remdesivir), monoclonal antibodies etesevimab tocilizumab), protease inhibitors paxlovid), glucocorticoids dexamethasone).Increasing evidence suggests circulating microRNAs (miRNAs) are important regulators viral infection antiviral immune responses, biological processes involved regulating COVID-19 subsequent complications.During infection, both genes host cytokines regulate transcriptional posttranscriptional steps affecting replication.Virus-encoded miRNAs component evasion repertoire function directly targeting functions.Moreover, can contribute escape play role not only promoting nonstructural protein (nsp) 10 expression SARS coronavirus, but among others inhibiting NOD-like receptor pyrin domain-containing (NLRP) 3 IL-1β transcription.Consequently, understanding mechanism action during SARS-CoV-2 will provide unexpected insights into miRNA-based studies.In this review, we examined recent progress regulation inflammatory response, dysfunction, thrombosis discussed mechanisms action, highlighted therapeutic challenges involving miRNA future research directions COVID-19.

Language: Английский

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Problems of Pathogenesis and Pathogenetic Therapy of COVID-19 from the Perspective of the General Theory of Pathological Systems (General Pathological Processes)

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(14), P. 7582 - 7582

Published: July 15, 2021

The COVID-19 pandemic examines not only the state of actual health care but also fundamental medicine in various countries. Pro-inflammatory processes extend far beyond classical concepts inflammation. They manifest themselves a variety ways, beginning with extreme physiology, then allostasis at low-grade inflammation, and finally shockogenic phenomenon “inflammatory systemic microcirculation”. pathogenetic core critical situations, including COVID-19, is this phenomenon. Microcirculatory abnormalities, on other hand, lie heart specific type general pathological process known as inflammation (SI). Systemic inflammatory response, cytokine release, storm, thrombo-inflammatory syndrome are all terms that refer to different aspects SI. As result, metabolic model does adequately reflect pathophysiology persistent (ChSLGI). Diseases associated ChSLGI, risk factors for severe course. review role hypoxia, dysfunction, scavenger receptors, pattern-recognition well hemophagocytic syndrome, alteration development SI COVID-19.

Language: Английский

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Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 2011 - 2011

Published: July 24, 2023

With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components cells, are natural nanoscale particles that transport variety biological molecules and facilitate cell-to-cell communication which been also widely used targeted drug delivery. These nanocarriers exhibit inherent advantages, such strong cell or tissue targeting low immunogenicity, synthetic lack. However, despite tremendous therapeutic EVs, further clinical application is still limited by yield lack standardized isolation purification protocols. In recent years, inspired concept biomimetics, new approach to biomimetic delivery has developed through combining nanotechnology bioengineering. This article reviews derived from EVs discusses advantages challenges order stimulate future research.

Language: Английский

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Regulatory role of miRNAs in the human immune and inflammatory response during the infection of SARS‐CoV‐2 and other respiratory viruses: A comprehensive review

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(2)

Published: March 1, 2024

miRNAs are single-stranded ncRNAs that act as regulators of different human body processes. Several have been noted to control the immune and inflammatory response during severe acute respiratory infection syndrome (SARS-CoV-2) infection. Similarly, many were upregulated downregulated virus infections. Here, an attempt has made capture regulatory role in SARS-CoV-2 other viruses. Firstly, depicted SARS-CoV-2. In this direction, several significant points discussed about infection, such innate response; its regulation granulocytes; macrophage activation polarisation; neutrophil extracellular trap formation; miRNA-related association adaptive immunity. Secondly, landscape infections coronavirus, syncytial virus, influenza rhinovirus, metapneumovirus. The article will provide more understanding miRNA-controlled mechanism COVID-19, which help therapeutics discoveries fight against future pandemic.

Language: Английский

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Mesenchymal Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 3, 2022

Microbial diseases are a global health threat, leading to tremendous casualties and economic losses. The strategy treat microbial falls into two broad categories: pathogen-directed therapy (PDT) host-directed (HDT). As the typical PDT, antibiotics or antiviral drugs directly attack bacteria viruses through discerning specific molecules. However, drug abuse could result in antimicrobial resistance increase infectious disease morbidity. Recently, exosome therapy, as HDT, has attracted extensive attentions for its potential limiting complications targeted delivery. Mesenchymal stem cell-derived exosomes (MSC-Exos) most broadly investigated. In this review, we mainly focus on development recent advances of application MSC-Exos diseases. review starts with difficulties current strategies treatments, followed by comprehensive overview aspect isolation, identification, contents, applications. Then, underlying mechanisms MSC-Exo discussed depth, including immunomodulation, repression excessive inflammation, promotion tissue regeneration. addition, highlight latest progress clinical translation summarizing related trials, routes administration, modifications. This will provide fundamental insights future perspectives from bench bedside.

Language: Английский

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Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Management of COVID19-Associated Lung Injury: A Review on Publications, Clinical Trials and Patent Landscape

Tissue Engineering and Regenerative Medicine, Journal Year: 2022, Volume and Issue: 19(4), P. 659 - 673

Published: April 6, 2022

Language: Английский

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microRNAs and Inflammatory Immune Response in SARS-CoV-2 Infection: A Narrative Review

Life, Journal Year: 2022, Volume and Issue: 12(2), P. 288 - 288

Published: Feb. 15, 2022

The current SARS-CoV-2 pandemic has emerged as an international challenge with strong medical and socioeconomic impact. spectrum of clinical manifestations is wide, covering asymptomatic or mild cases up to severe life-threatening complications. Critical courses infection are thought be driven by the so-called “cytokine storm”, derived from excessive immune response that induces release proinflammatory cytokines chemokines. In recent years, non-coding RNAs (ncRNAs) potential diagnostic therapeutic biomarkers in both inflammatory infectious diseases. Therefore, identification miRNAs host important research topic, investigating host–virus crosstalk COVID-19 infection, trying answer pressing question whether miRNA-based therapeutics can employed tackle this review, we aimed directly address ncRNA role SARS-CoV-2-immune system upon particularly focusing on pathways cytokine storm syndromes.

Language: Английский

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miRNAs: The Key Regulator of COVID-19 Disease

International Journal of Cell Biology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 19

Published: Oct. 29, 2022

As many parts of the world continue to fight innumerable waves COVID-19 infection, SARS-CoV-2 continues sculpt its antigenic determinants enhance virulence and evolvability. Several vaccines were developed used around world, oral antiviral medications are being against SARS-CoV-2. However, studies showed that virus is mutating in line with antibody's neutralization escape; thus, new therapeutic alternatives solicited. We hereby review key role miRNAs can play as epigenetic mediators cross-talk between host cells. The limitations resulting from "virus intelligence" escape antagonize well possible mechanisms could be viral evasion strategies discussed. Lastly, we suggest approaches based on miRNAs.

Language: Английский

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RETRACTED: Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significance

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 222, P. 1538 - 1550

Published: Sept. 22, 2022

Language: Английский

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