3 Biotech,
Journal Year:
2024,
Volume and Issue:
14(12)
Published: Nov. 28, 2024
Abstract
The
goal
of
the
research
was
to
develop
a
hydrophobic
octanoate
salt
chitosan
(CS–OA)
and
use
as
nanoparticle
platform
for
delivery
curcumin
(CUR)
into
prostate
cancer
cells.
nanoprecipitation
technique
used
prepare
nanoparticles,
which
were
measured
particle
size
encapsulation
efficacy
relative
CUR–CS
nanoparticles.
cytotoxicity
CUR–OA–CS
nanoparticles
evaluated
in
cancerous
cells
(PC3
DU145)
comparison
with
corresponding
blank
hydroalcoholic
CUR
solution.
PXRD,
SEM,
TEM
also
examine
CUR–CS–OA
average
diameters
268.90
±
3.77
nm
221.90
2.79
nm,
respectively,
efficiencies
61.37
1.70%
60.20
3.17%.
PXRD
SEM
suggested
amorphization
CS–OA
void
exhibited
concentration-dependent
antiproliferative
action,
attributed
cellular
uptake
CS.
loading
these
increased
their
even
more.
potential
special
system
additional
cytotoxic
drugs
different
malignant
can
be
further
explored.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 18, 2025
Clinically,
multimodal
therapies
are
adopted
worldwide
for
the
management
of
cancer,
which
continues
to
be
a
leading
cause
death.
In
recent
years,
immunotherapy
has
firmly
established
itself
as
new
paradigm
in
cancer
care
that
activates
body's
immune
defense
cope
with
cancer.
Immunotherapy
resulted
significant
breakthroughs
treatment
stubborn
tumors,
dramatically
improving
clinical
outcome
patients.
Multiple
forms
immunotherapy,
including
checkpoint
inhibitors
(ICIs),
adoptive
cell
therapy
and
vaccines,
have
become
widely
available.
However,
effectiveness
these
immunotherapies
is
not
much
satisfying.
Many
patients
do
respond
disease
recurrence
appears
unavoidable
because
rapidly
evolving
resistance.
Moreover,
can
give
rise
severe
off-target
immune-related
adverse
events.
Strategies
remove
hindrances
mainly
focus
on
development
combinatorial
or
exploitation
novel
immunotherapeutic
mediations.
Nanomaterials
carrying
anticancer
agents
target
site
considered
practical
approaches
treatment.
Nanomedicine
combined
offers
possibility
potentiate
systemic
antitumor
immunity
facilitate
selective
cytotoxicity
against
cells
an
effective
safe
manner.
A
myriad
nano-enabled
currently
under
investigation.
Owing
gaps
between
preclinical
studies,
nano-immunotherapy
faces
multiple
challenges,
biosafety
nanomaterials
trial
design.
this
review,
we
provide
overview
summarize
evidence
indicating
how
nanomedicine-based
increase
efficacy
immunotherapies.
We
also
discuss
key
challenges
emerged
era
nanotechnology-based
immunotherapy.
Taken
together,
combination
drawing
increasing
attention,
it
anticipated
will
achieve
desired
success
therapy.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Glioblastoma
(GBM)
remains
one
of
the
most
aggressive
and
treatment-resistant
brain
tumors,
necessitating
innovative
therapeutic
approaches.
Polymer-based
nanotechnology
has
emerged
as
a
promising
solution,
offering
precise
drug
delivery,
enhanced
blood-brain
barrier
(BBB)
penetration,
adaptability
to
tumor
microenvironment
(TME).
This
review
explores
diverse
applications
polymeric
nanoparticles
(NPs)
in
GBM
treatment,
including
delivery
chemotherapeutics,
targeted
therapeutics,
immunotherapeutics,
other
agents
for
radiosensitization
photodynamic
therapy.
Recent
advances
multifunctional
polymer
highlight
their
potential
overcome
challenges
that
brought,
such
heterogeneity
tumor,
BBB
limitation,
immunosuppressive
TME,
consideration
biocompatibility
safety.
Meanwhile,
future
directions
address
these
are
also
proposed.
By
addressing
obstacles,
polymer-based
represents
transformative
strategy
improving
treatment
outcomes,
paving
way
more
effective
patient-specific
therapies.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Magnetic
resonance
imaging
(MRI)
is
a
cornerstone
technology
in
clinical
diagnostics
and
vivo
research,
offering
unparalleled
visualization
capabilities.
Despite
significant
advancements
the
past
century,
traditional
1
H
MRI
still
faces
sensitivity
limitations
that
hinder
its
further
development.
To
overcome
this
challenge,
hyperpolarization
methods
have
been
introduced,
disrupting
thermal
equilibrium
of
nuclear
spins
leading
to
an
increased
proportion
hyperpolarized
spins,
thereby
enhancing
by
hundreds
tens
thousands
times.
Among
these
methods,
(HP)
129
Xe
MRI,
also
known
as
ultrasensitive
stands
out
for
achieving
highest
polarization
enhancement
has
recently
received
approval.
It
effectively
tackles
challenge
weak
signals
from
low
proton
density
lungs.
HP
valuable
assessing
structural
functional
changes
lung
physiology
during
pulmonary
disease
progression,
tracking
cells,
detecting
target
molecules
at
pico‐molar
concentrations.
This
review
summarizes
recent
developments
including
physical
principles,
manufacturing
characteristics,
diverse
applications
biomedical,
chemical,
material
sciences.
In
addition,
it
carefully
discusses
potential
technical
improvements
future
prospects
utility
fields,
establishing
MRI's
importance
advancing
medical
research.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 14, 2024
RNA
therapeutics,
such
as
mRNA,
siRNA,
and
CRISPR–Cas9,
present
exciting
avenues
for
treating
diverse
diseases.
However,
their
potential
is
commonly
hindered
by
vulnerability
to
degradation
poor
cellular
uptake,
requiring
effective
delivery
systems.
Lipid
nanoparticles
(LNPs)
have
emerged
a
leading
choice
in
vivo
delivery,
offering
protection
against
degradation,
enhanced
facilitation
of
endosomal
escape.
LNPs
encounter
numerous
challenges
targeted
vivo,
demanding
advanced
particle
engineering,
surface
functionalization
with
targeting
ligands,
profound
comprehension
the
biological
milieu
which
they
function.
This
review
explores
structural
physicochemical
characteristics
LNPs,
in-vivo
fate,
customization
therapeutics.
We
highlight
quality-by-design
(QbD)
approach
beyond
liver,
focusing
on
biodistribution,
immunogenicity,
toxicity.
In
addition,
we
explored
current
strategies
associated
ensuring
repeated-dose
efficacy,
safety,
tissue-specific
gene
delivery.
Furthermore,
provide
insights
into
clinical
applications
various
classes
diseases
finally
prospects
iScience,
Journal Year:
2024,
Volume and Issue:
27(5), P. 109823 - 109823
Published: April 26, 2024
Pulmonary
embolism
caused
by
deep
vein
thrombosis
(DVT)
is
a
major
contributor
to
maternal
morbidity
and
mortality.
There
still
an
unmet
need
for
safe
effective
treatment
options
DVT
during
pregnancy.
Recent
research
has
shown
that
neutrophil
extracellular
trap
(NET)
formation
plays
very
vital
role
in
thrombosis.
We
created
nanoparticles
surface-modified
elastase
(NE)-binding
peptide
can
target
activated
neutrophils
specifically
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Nanoparticles
capable
of
dynamically
reporting
their
structural
integrity
in
real-time
are
a
powerful
tool
to
guide
the
design
drug
delivery
technologies.
Molecular Therapy — Methods & Clinical Development,
Journal Year:
2025,
Volume and Issue:
33(1), P. 101436 - 101436
Published: Feb. 16, 2025
Lipid
nanoparticles
(LNPs)
are
now
highly
effective
transporters
of
nucleic
acids
to
the
liver.
This
liver-specificity
is
largely
due
their
association
with
certain
serum
proteins,
most
notably
apolipoprotein
E
(ApoE),
which
directs
them
liver
cells
by
binding
low-density
lipoprotein
(LDL)
receptors
on
hepatocytes.
The
liver's
distinct
anatomy,
its
various
specialized
cell
types,
also
influences
how
LNPs
taken
up
from
circulation,
cleared,
and
they
in
delivering
treatments.
In
this
review,
we
consider
factors
that
facilitate
LNP's
targeting
explore
latest
advances
liver-targeted
LNP
technologies.
Understanding
targeted
can
help
for
design
optimization
nanoparticle-based
therapies.
Comprehension
cellular
interaction
biodistribution
not
only
leads
better
treatments
diseases
but
delivers
insight
directing
other
tissues,
potentially
broadening
range
therapeutic
applications.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 1814 - 1814
Published: Feb. 20, 2025
Localization
in
the
central
nervous
system,
diffuse
growth,
presence
of
stem
cells,
and
numerous
resistance
mechanisms,
all
make
glioblastoma
(GBM)
an
incurable
tumor.
The
standard
treatment
GBM
consisting
surgery;
radio-
chemotherapy
with
temozolomide
provides
insufficient
therapeutic
benefit
needs
to
be
updated
effective
modern
solutions.
One
most
promising
intensively
explored
approaches
against
is
use
nanotherapy.
first,
so
far
only,
nanoparticle-based
therapy
approved
for
NanoThermTM.
It
based
on
iron
oxide
nanoparticles
thermal
ablation
tumor
a
magnetic
field.
Numerous
other
types
nanotherapies
are
being
evaluated,
including
polymer
lipid-based
nanoformulations,
nanodiscs,
dendrimers,
metallic,
silica,
or
bioderived
nanoparticles,
among
others.
advantages
these
nanoscale
drug
carriers
include
improved
penetration
across
blood-brain
barrier,
targeted
delivery,
biocompatibility,
lower
systemic
toxicity,
while
major
problems
their
implementation
involve
scaling
up
production
high
costs.
Nevertheless,
taking
impressive
benefits
into
consideration,
it
seems
obvious
that
combined
effort
scientific
world
will
need
taken
tackle
challenges
implement
novel
therapies
clinics,
giving
hope
battle
can
finally
won.
