Nutritional psychiatry: Towards improving mental health by what you eat

European Neuropsychopharmacology, Journal Year: 2019, Volume and Issue: 29(12), P. 1321 - 1332

Published: Nov. 14, 2019

Does it matter what we eat for our mental health? Accumulating data suggests that this may indeed be the case and diet nutrition are not only critical human physiology body composition, but also have significant effects on mood wellbeing. While determining factors of health complex, increasing evidence indicates a strong association between poor exacerbation disorders, including anxiety depression, as well other neuropsychiatric conditions. There common beliefs about certain foods supported by solid scientific demonstrating unequivocal link is beginning to emerge. Current epidemiological do provide information causality or underlying mechanisms. Future studies should focus elucidating mechanism. Randomized controlled trials high quality, adequately powered geared towards advancement knowledge from population-based observations personalized nutrition. Here, an overview emerging field nutritional psychiatry, exploring exemplifying importance well-balanced health. We conclude experimental medicine approach mechanistic understanding required which future policies can based.

Language: Английский

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Periodontal Inflammation and Systemic Diseases: An Overview

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 27, 2021

Periodontitis is a common inflammatory disease of infectious origins that often evolves into chronic condition. Aside from its importance as stomatologic ailment, periodontitis has gained relevance since it been shown can develop systemic condition characterized by unresolved hyper-inflammation, disruption the innate and adaptive immune system, dysbiosis oral, gut other location's microbiota system-wide alterations may cause, coexist or aggravate health issues associated to elevated morbi-mortality. The relationships between infectious, immune, inflammatory, features many related diseases are far being fully understood indeed still debated. However, date, large body evidence on different biological, clinical, policy-enabling sources information, available. aim present work summarize these information contextualize them under inflammation framework set basis an integral vision, useful for basic, therapeutic goals.

Language: Английский

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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Molecular Neurodegeneration, Journal Year: 2022, Volume and Issue: 17(1)

Published: Sept. 24, 2022

Abstract ApoE is the major lipid and cholesterol carrier in CNS. There are three human polymorphisms, apoE2, apoE3, apoE4, genetic expression of APOE4 one most influential risk factors for development late-onset Alzheimer's disease (AD). Neuroinflammation has become third hallmark AD, together with Amyloid-β plaques neurofibrillary tangles hyperphosphorylated aggregated tau protein. This review aims to broadly extensively describe differential aspects concerning apoE. Starting from evolution apoE how APOE's single-nucleotide polymorphisms affect its structure, function, involvement during health disease. reflects on impact critical AD pathology, such as neuroinflammatory response, particularly effect APOE astrocytic microglial function dynamics, synaptic amyloid-β load, autophagy, cell–cell communication. We discuss affecting pathology combined genotype, sex, age, diet, physical exercise, current therapies clinical trials field. The genotype other neurodegenerative diseases characterized by overt inflammation, e.g., alpha- synucleinopathies Parkinson's disease, traumatic brain injury, stroke, amyotrophic lateral sclerosis, multiple also addressed. Therefore, this gathers relevant findings related up date implications CNS pathologies provide a deeper understanding knowledge

Language: Английский

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Promoting Successful Cognitive Aging: A Ten-Year Update

Journal of Alzheimer s Disease, Journal Year: 2021, Volume and Issue: 81(3), P. 871 - 920

Published: April 27, 2021

A decade has passed since we published a comprehensive review in this journal addressing the topic of promoting successful cognitive aging, making good time to take stock field. Because there have been limited large-scale, randomized controlled trials, especially following individuals from middle age late life, some experts questioned whether recommendations can be legitimately offered about reducing risk decline and dementia. Despite uncertainties, clinicians often need at least make provisional patients based on highest quality data available. Converging lines evidence epidemiological/cohort studies, animal/basic science human proof-of-concept intervention studies provide guidance, highlighting strategies for enhancing reserve preventing loss capacity. Many suggestions made 2010 supported by additional research. Importantly, is growing consensus among major health organizations mitigate promote healthy aging. Regular physical activity treatment cardiovascular factors all these organizations. Most also embraced cognitively stimulating activities, heart-healthy diet, smoking cessation, countering metabolic syndrome. Other behaviors like regular social engagement, limiting alcohol use, stress management, getting adequate sleep, avoiding anticholinergic medications, sensory deficits, protecting brain against toxic damage endorsed, although less consistently. In update, each offer practical advice behavior-change techniques help adopt brain-healthy behaviors.

Language: Английский

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Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10572 - 10572

Published: Sept. 12, 2022

Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it the most common cause of dementia and has no treatment. It characterized by two pathological hallmarks, extracellular deposits amyloid beta (Aβ) intraneuronal Neurofibrillary tangles (NFTs). Yet, those hallmarks do not explain full pathology seen with AD, suggesting involvement other mechanisms. Neuroinflammation could offer another explanation for progression disease. This review provides an overview recent advances on role immune cells' microglia astrocytes in neuroinflammation. In become reactive several mechanisms leading to release proinflammatory cytokines that further neuronal damage. We then provide updates neuroinflammation diagnostic markers investigational therapeutics currently clinical trials target

Language: Английский

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Diet in the Prevention of Alzheimer’s Disease: Current Knowledge and Future Research Requirements

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4564 - 4564

Published: Oct. 30, 2022

Alzheimer’s disease is a progressive brain that becoming major health problem in today’s world due to the aging population. Despite it being widely known diet has significant impact on prevention and progression of disease, literature data are still scarce controversial. The application principles rational nutrition for elderly suggested disease. should be rich neuroprotective nutrients, i.e., antioxidants, B vitamins, polyunsaturated fatty acids. Some studies suggest diets such as Mediterranean diet, DASH (Dietary Approaches Stop Hypertension) MIND (Mediterranean-DASH Intervention Neurodegenerative Delay) have beneficial effect risk developing

Language: Английский

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The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1436 - 1436

Published: March 16, 2023

Neurological diseases are recognized as major causes of disability and mortality worldwide. Due to the dynamic progress such Alzheimer’s disease (AD), Parkinson’s Disease (PD), Schizophrenia, Depression, Multiple Sclerosis (MD), scientists mobilized look for new more effective methods interventions. A growing body evidence suggests that inflammatory processes an imbalance in composition function gut microbiome, which play a critical role pathogenesis various neurological dietary interventions, Mediterranean diet DASH diet, or ketogenic can have beneficial effects on their course. The aim this review was take closer at its ingredients modulating inflammation associated with development and/or progression central nervous system diseases. Presented data shows consuming abundant fruits, vegetables, nuts, herbs, spices, legumes sources anti-inflammatory elements omega-3 fatty acids, polyphenols, vitamins, essential minerals, probiotics while avoiding foods promote inflammation, create positive brain environment is reduced risk Personalized nutritional interventions may constitute non-invasive strategy combating disorders.

Language: Английский

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Mediterranean Diet and Quality of Life in Adults: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 577 - 577

Published: Feb. 5, 2025

Background/Objectives: With the increasing life expectancy and, as a result, aging of global population, there has been rise in prevalence chronic conditions, which can significantly impact individuals’ health-related quality life, multidimensional concept that comprises an individual’s physical, mental, and social wellbeing. While balanced, nutrient-dense diet, such Mediterranean is widely recognized for its role disease prevention, particularly reducing risk cardiovascular diseases certain cancers, potential benefits extend beyond these well-known effects, showing promise improving physical mental wellbeing, promoting life. Methods: A systematic search scientific literature electronic databases (Pubmed/Medline) was performed to identify potentially eligible studies reporting on relation between adherence diet published up December 2024. Results: total 28 were included this review, comprising 13 conducted among general population 15 involving various types patients. Overall, most showed significant association HRQoL, with results retrieved domains suggesting seems play relevant both people affected by conditions inflammatory basis. Conclusions: Adherence provides preventing managing commonly associated populations. Furthermore, it enhances overall health individuals, ultimately supporting more effective less invasive treatment approaches diseases.

Language: Английский

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Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease

Frontiers in Aging Neuroscience, Journal Year: 2020, Volume and Issue: 11

Published: Jan. 10, 2020

Alzheimer's disease (AD) is one of the incurable neurodegenerative diseases characterised by accumulation amyloid-beta (plaques) and tau hyperphosphorylation (neurofibrillary tangles) in brain followed neuronal death, cognitive decline memory loss. The high prevalence AD developed world has become a major public health challenge associated with social economic burden on individuals society. Due to limited options early diagnosis exact pathophysiology AD, finding effective therapeutic strategies great challenge. Several possible risk factors pathology have been identified; however their conclusive role still unknown. Recent clinical trials drugs targeting are failing any cure for pathology. Therefore preventive should be reduce exponential increase dementia, especially AD. Although search new targets scientific community, lifestyle interventions nutraceuticals prevention many metabolic highly appreciated literature. In this article, we summarised molecular mechanisms involved ameliorative action nutritional including diet, exercise, calorie restrictions, various bioactive compounds dementia. This article will provide insights into non-pharmacologic modulation pathology, which may offer benefit improving quality life reducing incident

Language: Английский

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Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 232, P. 108013 - 108013

Published: Oct. 6, 2021

Language: Английский

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