Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations DOI Open Access

Lorena Ciumărnean,

Oliviu Florențiu Sârb, Nicu Cătălin Drăghici

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10909 - 10909

Published: Oct. 10, 2024

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, brain’s ability to adapt its structure function, plays a crucial role in mitigating MS’s impact. This paper explores potential benefits of lifestyle changes nutraceuticals on brain plasticity MS population. Lifestyle modifications, including physical activity dietary adjustments, can enhance upregulating neurotrophic factors, promoting synaptogenesis, reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, antioxidants like alpha lipoic acid, have shown promise supporting health through anti-inflammatory neuroprotective mechanisms. Regular has been linked increased levels brain-derived factor improved cognitive function. Dietary interventions, caloric restriction intake polyphenols, also positively influence plasticity. Integrating these into management provide complementary approach traditional therapies, potentially improving neurological outcomes enhancing quality life for

Language: Английский

Curcumin Solubility and Bioactivity Enhancement Through Amorphization with Tryptophan via Supercritical Fluid Technology DOI Open Access
Ewa Garbiec, Natalia Rosiak, Szymon Sip

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 855 - 855

Published: Jan. 20, 2025

Curcumin, a compound known for its antioxidant and neuroprotective properties, faces challenges due to low water solubility, which can limit effectiveness. One effective method address this issue is through amorphization. Incorporating curcumin into polymeric matrix form amorphous solid dispersions common approach. Another strategy involves co-amorphous systems, where low-molecular-weight components act as co-formers. A recent innovative approach combines these strategies. This study used tryptophan co-former prepared systems using supercritical fluid technology. The nature of two was confirmed X-ray powder diffraction: one with 10% polymer, another curcumin, tryptophan. Fourier-transform infrared analysis demonstrated molecular interactions among all in the systems. Scanning electron microscopy revealed that amorphization process significantly modified morphology particles. ternary system notably increased solubility by over 300-fold. both exhibited higher dissolution rates compared crystalline form. showed more than threefold improvement permeability according PAMPA test. enhanced led sixfold increase activity 25-fold inhibition enzyme butyrylcholinesterase.

Language: Английский

Citations

2
Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials DOI

Nasim Azari Torbat,

Iman Akbarzadeh,

Niloufar Rezaei

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 492, P. 215233 - 215233

Published: June 6, 2023

Language: Английский

Citations

22
Recent advances in curcumin-loaded biomimetic nanomedicines for targeted therapies DOI

Fenting Lei,

Pei Li, Tangting Chen

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 80, P. 104200 - 104200

Published: Jan. 23, 2023

Language: Английский

Citations

15
Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives DOI

Shamili Mariya Varghese,

Shashikant Patel,

Amritasree Nandan

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10398 - 10447

Published: May 10, 2024

Language: Английский

Citations

6
Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review DOI Creative Commons
Maoyuan Zhao, Wei Feng,

Guangwei Sun

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

Gastric cancer, a common malignant disease, seriously endangers human health and life. The high mortality rate due to gastric cancer can be attributed lack of effective therapeutic drugs. Cancer cells utilize the glycolytic pathway produce energy even under aerobic conditions, commonly referred as Warburg effect, which is characteristic cancer. identification new targets based on for treatment viable option, accumulating evidence has shown that phytochemicals have extensive anti-glycolytic properties. We reviewed effects mechanisms action glycolysis in cells. Phytochemicals effectively inhibit cells, suppress cell proliferation migration, promote apoptosis, via PI3K/Akt, c-Myc, p53, other signaling pathways. These pathways affect expressions HIF-1α, HK2, LDH, glycolysis-related proteins. This review further assesses potential using plant-derived compounds sheds insight into development

Language: Английский

Citations

18
Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications DOI

Fatemeh Askarizadeh,

Alexandra E. Butler, Prashant Kesharwani

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115369 - 115369

Published: March 1, 2025

Language: Английский

Citations

0
Nanoencapsulation of Turmeric Bioactive Compounds in Zein Nanoparticles: Optimization, Characterization, and Anticancer Potential DOI

Mariane de Souza Parra Agostinho,

Danielli Andrea Nardino,

Elisângela Düsman

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract Turmeric ( Curcuma longa ) is a rich source of bioactive compounds, particularly curcuminoids, known for their potent antioxidant, anti‐inflammatory, and anticancer properties. However, hydrophobic nature limits bioavailability. This study aimed to encapsulate turmeric extract in zein nanoparticles coated with sodium caseinate chitosan enhance stability bioactivity. The demonstrated high antioxidant activity: (DPPH (2,2‐diphenyl‐1‐picrylhydrazyl): 94.15%, ABTS: 82.46%, Fe(II) chelation: 57.05%) contained significant phenolic (1737.13 mg GAE (equivalent gallic acid)/100 g) flavonoid (5548.77 RUE (mg rutin 100 g−1 the sample)/100 content. Nanoparticles were optimized at 1:0.8 zein/sodium ratio (183.53 nm), 10% loading (229.32 nm) 0.050% coating (226.51 nm). Encapsulation efficiency reached 66%, capacity 6.6%. Cytotoxicity assays revealed activity against renal (786‐0) liver (HUH7.5) tumor cells, suggesting therapeutic potential, respectively. highlights efficacy nanoencapsulation improving delivery bioactives pharmaceutical applications.

Language: Английский

Citations

0
The effect of curcumin on postpartum depression and anxiety in primiparous women: a double-blind randomized placebo-controlled clinical trial DOI Creative Commons

Elham Pishevar Hamlbar,

Mojgan Mirghafourvand‬‬‬‬‬‬‬‬‬‬‬‬‬‬, Elnaz Shaseb

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 25, 2025

Postpartum depression and anxiety are common problems in primiparous women, which can negatively affect Maternal-infant bonding lead to sexual disorders. It's important prevent treat these issues, especially since medication options during breastfeeding may be limited. Our study aimed investigate the effect of curcumin, a natural substance known for its beneficial properties, on postpartum women. A randomized controlled clinical trial was conducted 96 women Tabriz City. Participants were randomly assigned either intervention group (n = 48) or control using random block method. The received curcumin capsules with dose 500 mg, while placebo same once daily eight weeks. Data collected Edinburgh Postnatal Depression Scale (EPDS) postpartum-specific Anxiety research short-form (PSAS-RSF) questionnaires. After intervention, mean score (mean difference: -2.5; 95% confidence interval: -3.3 -1.7; P < 0.001) (Mean -1.4; -2.1 -0.7; significantly lower than group. It seems that improve mental health quality life due efficacy reducing depression, easy accessibility, cost-effectiveness.

Language: Английский

Citations

0
Non-linear association between Mediterranean diet and depressive symptom in U.S. adults: A cross-sectional study DOI Creative Commons
Yaohua Fan,

Lijun Zhao,

Zhiyuan Deng

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: July 15, 2022

The Mediterranean diet (MED), a dietary pattern rich in fruits and vegetables, whole grains, legumes, nuts, fish, olive oil, has anti-oxidative anti-inflammatory effects. Although some data suggest that MED adherence is associated with decreased manifestation of depressive symptoms, it remains necessary to further analyze this apparent non-linear association as well the influence different factors on relationship between depression. Here, we investigated associations alternate (aMED) score symptom via multivariate logistic regression, weighted generalized additive (GAM) two-step linear regression models, analyzing from 2005-2018 National Health Nutrition Examination Survey (NHANES). most important factor relevant aMED contributed prevalence was assessed using random forest. Furthermore, examined whether differs by age, race, sex, socioeconomic variables, lifestyle- health-related chronic medical conditions, subgroup analyses. A total 19,477 participants (20-80 years age) were included cross-sectional study. In crude adjusted (1-5) increased noted associate non-depressive status, defined Patient Questionnaire-9 (P < 0.05). Data analyses GAM two-piecewise revealed symptom, which had an inflection point 3. Random forest results vegetable contributes greatest symptom. Subgroup significantly negatively related populations 0.05) exception high annual income, diabetes, borderline blood glucose level Parkinson's disease (PD) > conclusion, observed Further studies are needed validate our results.

Language: Английский

Citations

16
Mechanistic insights into the anti-depressant effect of curcumin based on network pharmacology and experimental validation DOI
Jing Guo, Meng Fang,

Zhe Xiong

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(1), P. 583 - 598

Published: July 25, 2023

Language: Английский

Citations

9