A Novel Finding of an HLA Allele’s and a Haplotype’s Relationship with SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis DOI Creative Commons
Melisa Şahin Tekin, Göknur Yorulmaz, Emel Yantır

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(12), P. 1986 - 1986

Published: Nov. 23, 2022

Subacute thyroiditis (SAT) is a thyroid disease associated with viral infections. Its relationship major histocompatibility complex (MHC) antigens was shown before. SAT cases triggered by different types of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been reported. In this study, human leukocyte antigen (HLA) genotypes 27 patients (13 vaccine-associated (V-SAT) and 14 non-SARS-CoV-2-infection non-vaccine-associated (non-V-SAT)) were compared those 362 healthy donors. HLA analyses performed low-resolution DNA-based sequence-specific oligonucleotide or primer methods. Statistical using IBM SPSS Statistics 25 Stata/MP 14.1 the hapipf function. Allele haplotype frequencies estimated PyPop gene[RATE] tool programs. The allele HLA-A*11, HLA-B*35, HLA-C*04 higher in patient groups. Both frequency HLA-A*11 A*11-B*35-C*04 V-SAT group. haplotype, including all three loci MHC class I genes, to be for first time, especially This finding will contribute better understanding etiopathogenesis role functioning mechanisms SARS-CoV-2 vaccines.

Language: Английский

Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis DOI

Wilmar M. Wiersinga,

Kris Poppe, Grigoris Effraimidis

et al.

The Lancet Diabetes & Endocrinology, Journal Year: 2023, Volume and Issue: 11(4), P. 282 - 298

Published: Feb. 24, 2023

Language: Английский

Citations

115
Current concepts regarding Graves’ orbitopathy DOI Creative Commons
Luigi Bartalena, Maria Laura Tanda

Journal of Internal Medicine, Journal Year: 2022, Volume and Issue: 292(5), P. 692 - 716

Published: May 23, 2022

Graves' orbitopathy (GO) is an orbital autoimmune disorder and the main extrathyroidal manifestation of disease, most common cause hyperthyroidism. GO affects about 30% patients, although fewer than 10% have severe forms requiring immunosuppressive treatments. Management requires a multidisciplinary approach. Medical therapies for active moderate-to-severe (traditionally, high-dose glucocorticoids) often provide unsatisfactory results, subsequently surgeries are needed to cure residual manifestations. The aim this review updated overview current concepts regarding epidemiology, pathogenesis, assessment, treatment GO, present emerging targeted therapeutic perspectives. Original articles, clinical trials, systematic reviews, meta-analyses from 1980 2021 were searched using following terms: orbitopathy, thyroid eye glucocorticoids, radiotherapy, rituximab, cyclosporine, azathioprine, teprotumumab, TSH-receptor antibody, smoking, hyperthyroidism, hypothyroidism, thyroidectomy, radioactive iodine, antithyroid drugs. Recent studies suggest secular trend toward milder phenotype GO. Standardized assessment at clinic allows better general management plan. Treatment still relies in cases on systemic-mainly intravenous-glucocorticoids as monotherapy or combination with other therapies-such mycophenolate, radiotherapy-but novel biological agents-including tocilizumab-have achieved encouraging results.

Language: Английский

Citations

107
Thyroid dysfunction in COVID-19 DOI
David Tak Wai Lui, Chi‐Ho Lee,

Yu Cho Woo

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(6), P. 336 - 348

Published: Feb. 12, 2024

Language: Английский

Citations

20
COVID-19 and thyroid function: What do we know so far? DOI Creative Commons
Camila Lüdke Rossetti, Juliana Cazarin, Fábio Hecht

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 19, 2022

Coronavirus disease 2019 (COVID-19) was characterized as a pandemic in March, 2020 by the World Health Organization. COVID-19 is respiratory syndrome that can progress to acute distress syndrome, multiorgan dysfunction, and eventually death. Despite being considered disease, it known other organs systems be affected COVID-19, including thyroid gland. Thyroid gland, well hypothalamus pituitary, which regulate functioning of most endocrine glands, express angiotensin-converting enzyme 2 (ACE2), main protein functions receptor SARS-CoV-2 binds enter host cells. In addition, gland extremely sensitive changes body homeostasis metabolism. Immune system cells are targets for hormones T3 T4 modulate specific immune responses, cell-mediated immunity, natural killer cell activity, antiviral action interferon (IFN) proliferation T- B-lymphocytes. However, studies show patients with controlled hypothyroidism hyperthyroidism do not have higher prevalence nor they worse prognosis when infected virus. On hand, retrospective observational studies, prospective case reports published last two years reported abnormal function related infection or even several weeks after its resolution. Indeed, variety disorders been documented patients, non-thyroidal illness (NTIS), subacute thyroiditis thyrotoxicosis. has already consequence administration vaccines against SARS-CoV-2. Overall, data revealed may occur during convalescence post-COVID condition phase. Although cellular molecular mechanisms completely understood, evidence suggests “cytokine storm” an important mediator this context. Thus, future needed better investigate pathophysiology dysfunction induced at both clinical levels.

Language: Английский

Citations

59
Subacute thyroiditis – Is it really linked to viral infection? Retrospective hospital patient registry study DOI Creative Commons
Hans Martin Orth, Alexander Killer,

Smaranda Gliga

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Abstract Objective Subacute thyroiditis (SAT) is a painful inflammatory disorder of the thyroid gland, which – after phase thyrotoxicosis leads to transient, or less frequently permanent hypothyroidism. Apart from strong association with specific HLA alleles, causes are uncertain. Viral disease has been hypothesised as trigger, Enteroviruses, namely Echoviruses and Coxsackieviruses, showing seasonal distribution that coincides incidence SAT. In first year COVID-19 pandemic, strict hygiene measures led sharp decline in infections thus offered opportunity test this hypothesis. Methods We analysed national registry data hospitalised patients Germany during years 2015 2022 (Federal statistical Office (Destatis), Wiesbaden, Germany) surveillance on infectious diseases same (clinical-virology.net RKI). Statistical analysis includes modelling seasonality by month, polynomial autoregression Granger causality assess dependency future SAT frequencies past ones, virus frequency, respectively. Results Our study confirms previously described epidemiological findings higher females peak late summer coinciding enteroviruses until 2019. 2020, pattern remained unchanged, except for marked reduction other pathogens (except SARS-CoV-2) due hygienic measures. Moreover, 2021 was apparently unaltered through pandemic. Conclusions provides evidence despite their pattern, Coxsackieviruses not cause no (including Influenza A B, Parainfluenza, Rhinovirus, Human Coronaviruses including showed any association.

Language: Английский

Citations

1
SARS-CoV-2 vaccine may trigger thyroid autoimmunity: real-life experience and review of the literature DOI Open Access
Rosaria Maddalena Ruggeri,

L. Giovanellla,

Alfredo Campennì

et al.

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(12), P. 2283 - 2289

Published: July 12, 2022

Language: Английский

Citations

36
COVID-19 vaccination and thyroiditis DOI Open Access
Süleyman Nahit Şendur, Seda Hanife Oğuz, Uğur Ünlütürk

et al.

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101759 - 101759

Published: March 3, 2023

Language: Английский

Citations

18
Increased prevalence of autoimmune thyroid disease after COVID-19: A single-center, prospective study DOI Creative Commons
Alessandro Rossini,

Sara Cassibba,

F. Perticone

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 8, 2023

Thyroid dysfunctions associated with SARS-CoV-2 acute infection have been extensively described since the beginning of COVID-19 pandemics. Conversely, few data are available on occurrence thyroid autoimmunity after resolution. We assessed prevalence autoimmune disease (ATD) and in survivors three months hospital admission.Single-center, prospective, observational, cohort study performed at ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. 599 were prospectively evaluated for function thyroperoxidase antibodies (TPOAb), thyroglobulin (TgAb). When a positive antibody concentration was detected, ultrasound performed. Multiple logistic regression model used to estimate association between demographic characteristics, respiratory support, comorbidities. Autoimmunity results compared 498 controls referred our Institution non-thyroid diseases before pandemic onset. A sensitivity analysis comparing 330 patients age sex-matched performed.Univariate multivariate found that female sex positively (OR 2.01, SE 0.48, p = 0.003), type 2 diabetes (T2DM) negatively 0.36, 0.16, 0.025) autoimmunity; hospitalization, ICU admission, or treatment not (p > 0.05). TPOAb greater than controls: 15.7% vs 7.7%, 0.002. Ultrasonographic features thyroiditis present 94.9% antibodies. TSH within normal range 95% patients.Autoimmune doubled as controls, suggesting role eliciting autoimmunity.

Language: Английский

Citations

17
Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study DOI Open Access
Adnan Batman, Dilek Yazıcı, Oğuz Dikbaş

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 108(10), P. e1013 - e1026

Published: April 25, 2023

Abstract Context The aims of the study are to compare characteristics subacute thyroiditis (SAT) related different etiologies, and identify predictors recurrence SAT incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort included 53 endocrinology centers in Turkey. participants were divided into either COVID-19–related (Cov-SAT), SARS-CoV-2 vaccine–related (Vac-SAT), or control (Cont-SAT) groups. Results Of 811 patients, 258 (31.8%) Vac-SAT group, 98 (12.1%) Cov-SAT 455 (56.1%) Cont-SAT group. No difference was found between groups with regard laboratory imaging findings. etiology not an independent predictor In entire cohort, steroid therapy requirement younger age statistically significant for recurrence. C-reactive protein measured during onset, female sex, absence antithyroid peroxidase (TPO) positivity, (early) hypothyroidism, irrespective etiology. On other hand, probable established hypothyroidism differed from that Conclusion Since there is no terms follow-up parameters outcomes, COVID-19– can be treated followed up like classic SATs. Recurrence determined by requirement. Steroid independently predicts may sometimes transient overall also associated a lower risk

Language: Английский

Citations

14
Menstrual disturbances following COVID-19 vaccination: A probable puzzle about the role of endocrine and immune pathways DOI Open Access
Farima Rahimi Mansour, Amirreza Keyvanfar, Hanieh Najafiarab

et al.

Journal of Reproductive Immunology, Journal Year: 2023, Volume and Issue: 158, P. 103952 - 103952

Published: May 12, 2023

Language: Английский

Citations

14