Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19 DOI Creative Commons
David Kartchner, Kevin McCoy,

Janhvi Dubey

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(9), P. 1269 - 1269

Published: Sept. 21, 2023

Multiple studies have reported new or exacerbated persistent resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates Cross-domain text mining of 33+ million PubMed articles within a comprehensive knowledge graph was performed using SemNet 2.0. Unsupervised rank aggregation determined which concepts were most relevant utilizing the normalized HeteSim score. A series simulations identified directly related COVID-19 connected via one three renin–angiotensin–aldosterone system hub nodes (mineralocorticoid receptor, epithelial sodium channel, angiotensin I receptor). The top-ranking relating included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte prolactin, thyroid poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 COL1A1+COL1A2 QARS VPS54, TPM2, MPST, EXOSC2, ribosomal S10, TAP-144, gonadotropins, human gonadotropin hormone beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. Concepts mapped six physiological themes: altered endocrine function, 23.1%; inflammation cytokine storm, 21.3%; lipid metabolism atherosclerosis, 17.6%; sympathetic input blood pressure regulation, 16.7%; entry virus, 14.8%; unknown, 6.5%.

Language: Английский

Thyroid dysfunction in COVID-19 DOI
David Tak Wai Lui, Chi‐Ho Lee,

Yu Cho Woo

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(6), P. 336 - 348

Published: Feb. 12, 2024

Language: Английский

Citations

20
Thyroid function during COVID-19 and post-COVID complications in adults: a systematic review DOI Creative Commons

Anisha Panesar,

Palma Gharanei,

Natasha Khovanova

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 4, 2025

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) virus, has presented multifaceted health challenges. COVID-19 primarily targets system but also affects multiple organ systems, including endocrine system. Emerging evidence suggests interactions between thyroid function, phase of COVID-19, and prolonged symptoms known as post-COVID sequalae or long COVID. Several studies have reported that can induce dysfunction, leading to conditions such thyroiditis alterations in hormone levels. mechanisms through which SARS-CoV-2 include direct viral infection cells, thyroiditis, causes inflammation transient sustained well an excessive systemic immune response (cytokine storm). This is associated with elevated levels cytokines, IL-6, disrupt function lead nonthyroidal illness (NTIS). Medications administered during phase, corticosteroids antiviral drugs, impact actions. involvement gland COVID, postacute sequelae infection, area not defined, potential implications for understanding managing this condition. Persistent low-grade affecting over time ongoing exacerbate pre-existing conditions. Viral infections, SARS-CoV-2, trigger worsen autoimmune diseases, Hashimoto’s Graves’ disease. Long COVID may hypothalamic–pituitary–adrenal (HPA) axis, can, turn, affect hypothalamic-pituitary-thyroid (HPT) abnormal function. review was designed systematically capture recent literature on COVID-19-related dysfunction adult population, prognostic consequences effects patients A comprehensive search PubMed EMBASE databases conducted. systematic performed based Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement. Study quality assessed using Critical Appraisal Skills Programme (CASP). total 53 met inclusion criteria. summarises findings provides update current spectrum disorders, underscoring complex nature its far-reaching impacts human health.

Language: Английский

Citations

3
Post-COVID Syndrome in Adults—An Overview DOI Creative Commons
Rüdiger E. Scharf, Juan‐Manuel Anaya

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 675 - 675

Published: March 4, 2023

This article provides an overview of various aspects related to post-COVID syndrome. Apart from its prevalence, symptoms and sequelae, risk determinants, psychosocial implications, the pathogenesis condition is discussed in more detail. A focus on thrombo-inflammation SARS-CoV-2 infection, role neutrophil extracellular traps, prevalence venous thromboembolism made. Moreover, COVID-19 syndrome immunocompromising conditions, impact vaccination prevention treatment are reviewed. Autoimmunity a hallmark syndrome, and, therefore, another this article. Thus, misdirected cellular humoral immune responses can enhance latent autoimmunity Facing high cases worldwide, it be assumed that autoimmune disorders will increase globally over next few years. Recent advances identifying genetically determined variants may open avenue for better understanding susceptibility severity infection

Language: Английский

Citations

34
COVID-19 vaccination and thyroiditis DOI Open Access
Süleyman Nahit Şendur, Seda Hanife Oğuz, Uğur Ünlütürk

et al.

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101759 - 101759

Published: March 3, 2023

Language: Английский

Citations

19
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches DOI Creative Commons
Ali Attiq, Sheryar Afzal, Habibah A. Wahab

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4215 - 4240

Published: Sept. 1, 2024

Angiotensin-converting enzyme 2 receptors (ACE2R) are requisite to enter the host cells for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). ACE2R is constitutive and functions as a type I transmembrane metallo-carboxypeptidase in renin-angiotensin system (RAS). On thyroid follicular cells, allows SARS-CoV-2 invade gland, impose cytopathic effects produce endocrine abnormalities, including stiff back, neck pain, muscle ache, lethargy, enlarged, inflamed gland COVID-19 patients. Further damage perpetuated by sudden bursts of pro-inflammatory cytokines, which suggestive life-threatening known "cytokine storm". IL-1β, IL-6, IFN-γ, TNF-α identified key orchestrators cytokine storm. These inflammatory mediators upregulate transcriptional turnover nuclear factor-kappa B (NF-κB), Janus kinase/signal transducer activator transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), paving pathway storm-induced dysfunctions euthyroid sick syndrome, autoimmune diseases, thyrotoxicosis Targeted therapies with corticosteroids (dexamethasone), JAK inhibitor (baricitinib), nucleotide analogue (remdesivir) N-acetyl-cysteine have demonstrated effectiveness terms attenuating severity frequency dysfunctions, morbidity mortality Here, we review pathogenesis storms mechanisms pathways that establish connection between disorder COVID-19. Moreover, cross-talk interactions signalling therapeutic strategies address COVID-19-associated diseases also discussed herein.

Language: Английский

Citations

9
Review of organ damage from COVID and Long COVID: a disease with a spectrum of pathology DOI Creative Commons
Andrew G. Ewing, Špela Šalamon, Etheresia Pretorius

et al.

Medical Review, Journal Year: 2024, Volume and Issue: 5(1), P. 66 - 75

Published: July 1, 2024

Long COVID, as currently defined by the World Health Organization (WHO) and other authorities, is a symptomatic condition that has been shown to affect an estimated 10 %-30 % of non-hospitalized patients after one infection. However, COVID-19 can also cause organ damage in individuals without symptoms, who would not fall under current definition COVID. This damage, whether or not, lead various health impacts such heart attacks strokes. Given these observations, it necessary either expand COVID include recognize COVID-19-induced distinct affecting many asymptomatic infections. It important consider known adverse outcomes, including conditions cancers, be until harm thresholds are reached. Many more medical identified testing than those recognized through reported symptoms. therefore similarly while symptoms associated with there have displaying this characterization monitoring

Language: Английский

Citations

8
Growth hormone – releasing hormone in the immune system DOI Creative Commons
Agnieszka Siejka, Hanna Ławnicka,

Saikat Fakir

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract GHRH is a neuropeptide associated with diverse variety of activities in human physiology and immune responses. The present study reviews the latest information on involvement system inflammation, suggesting that antagonists may deliver new therapeutic possibility disorders related to dysfunction inflammation.

Language: Английский

Citations

8
Integrating single-cell sequencing and transcriptome analysis to unravel the mechanistic role of sialylation-related genes in sepsis-induced acute respiratory distress syndrome DOI Creative Commons
Xiaobing Liu, Yubi Huang, Hao Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Background Studies have shown that sialylation of C1 esterase inhibitors is crucial for their interaction with histones, and histone-C1 inhibitor complexes are detected in acute respiratory distress syndrome (ARDS), suggesting a potential role ARDS. However, the specific function ARDS remains unclear. Therefore, this study aimed to investigate mechanism sialylation-related genes (SRGs) sepsis-induced Methods The related datasets (GSE32707, GSE66890, GSE151263) were included study. Candidate identified by implementing differential expression analysis weighted gene co-expression network (WGCNA). Subsequently, further selection machine learning assessment confirmed key Following this, predictive ability as whole was evaluated creating nomogram model. Afterwards, enrichment analysis, construction regulatory networks, drug prediction implemented understand molecular mechanisms action genes. Furthermore, single-cell RNA sequencing (scRNA-seq) data conducted obtain cells. Additionally, cell communication pseudo-time analyses implemented. In end, levels assessed collecting clinical samples. Results CD19 GPR65 associated constructed model demonstrated exhibited robust capability Meanwhile, also found be significantly co-enriched apoptosis B-cell receptor signaling pathway. addition, some important regulators drugs targeting effects on predicted, such NEAT1, OIP5-AS1, alprostadil, tacrolimus. Further, scRNA-seq nine types, among which CD14 monocytes (CD14Mono) designated cell. Importantly, dynamic changes during differentiation CD14Mono. Also, we up-regulated group. Conclusion We ARDS, highlighting CD14Mono type implicated These findings offered theoretical support understanding

Language: Английский

Citations

1
SARS-CoV-2 infection and its effects on the endocrine system DOI Open Access
Charlotte Steenblock, Nicole Toepfner, Felix Beuschlein

et al.

Best Practice & Research Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 37(4), P. 101761 - 101761

Published: March 5, 2023

Language: Английский

Citations

17
COVID‐19‐induced autoimmune thyroiditis: Exploring molecular mechanisms DOI
Bita Mohammadi, Kamal Dua,

Mohammadreza Saghafi

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(8)

Published: July 29, 2023

Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) damages multiple organs, including the thyroid, by direct invasion and cell entry via angiotensin‐converting enzyme 2 or indirectly promoting excessive inflammation in body. The immune system is a critical factor antiviral immunity disease progression. In context of SARS‐CoV‐2 infection, may become overly activated, resulting shift from regulatory to effector responses, which subsequently promote development progression autoimmune diseases. incidence thyroid diseases, such as subacute thyroiditis, Graves' disease, Hashimoto's increases individuals with COVID‐19 infection. This phenomenon be attributed aberrant responses T‐cell subtypes, presence autoantibodies, impaired function, production inflammatory cytokines, namely interleukin (IL)‐6, IL‐1β, interferon‐γ, tumor necrosis factor‐α. Therefore, insights into involved according can help identify potential therapeutic approaches guide effective interventions alleviate patients' symptoms.

Language: Английский

Citations

15