Beneficial microbiomes for bioremediation of diverse contaminated environments for environmental sustainability: present status and future challenges

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 28(20), P. 24917 - 24939

Published: March 25, 2021

Language: Английский

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Biodiversity, and biotechnological contribution of beneficial soil microbiomes for nutrient cycling, plant growth improvement and nutrient uptake

Biocatalysis and Agricultural Biotechnology, Journal Year: 2021, Volume and Issue: 33, P. 102009 - 102009

Published: April 24, 2021

Language: Английский

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The hidden power of secondary metabolites in plant-fungi interactions and sustainable phytoremediation

Frontiers in Plant Science, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 12, 2022

The global environment is dominated by various small exotic substances, known as secondary metabolites, produced plants and microorganisms. Plants fungi are particularly plentiful sources of these molecules, whose physiological functions, in many cases, remain a mystery. Fungal metabolites (SM) diverse group substances that exhibit wide range chemical properties generally fall into one four main family groups: Terpenoids, polyketides, non-ribosomal peptides, or combination the latter two. They incredibly varied their functions often related to increased fitness respective fungus its environment, competing with other microbes interacting plant species. Several have essential roles biological control diseases beneficial microorganisms used for crop protection biofertilization worldwide. Besides direct toxic effects against phytopathogens, natural can promote root shoot development and/or disease resistance activating host systemic defenses. ability synthesize store biologically active potent source novel compounds agriculture becoming top priority SM research. In this review, we will discuss fungal-plant antifungal role signaling molecules induced acquired activities. Additionally, fungal mimic promotion such auxins, gibberellins, abscisic acid, which modulate growth under biotic stress. Moreover, present new trend regarding phytoremediation applications using achieve sustainable food production microbial diversity an eco-friendly environment.

Language: Английский

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Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(2), P. 93 - 93

Published: Jan. 24, 2025

Metabolomics has emerged as a transformative tool in the study of microbes, including pathogenic fungi, facilitating identification unique metabolic profiles that elucidate their mechanisms, host interactions, and treatment resistance. This review highlights key applications metabolomics understanding fungal metabolites essential for human virulence, such mycotoxins produced by various species, Aspergillus fumigatus (gliotoxin, fumagillins) Candida species (phenylethyl alcohol, TCA cycle metabolites), secondary contribute to pathogenicity. It also explores adaptations fungi relation drug resistance biofilm formation, revealing alterations pathways during infection, seen C. albicans auris. Furthermore, aids deciphering host–pathogen showcasing how like Cryptococcus neoformans modify metabolism promote survival evade immune responses. The antifungal mechanisms benefited from metabolomic approaches, identifying specific metabolite patterns signify resistance, Candidozyma (Candida) auris, informing new therapeutic strategies. integration with other omics technologies is paving way comprehensive biology pathogenesis. Such multi-omics approaches are crucial discovering targets developing innovative treatments. Thus, purpose this provide an overview revolutionizing our pathogenesis, highlight its potential improving

Language: Английский

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Bacteria and fungi as major bio-sources to fabricate silver nanoparticles with antibacterial activities

Expert Review of Anti-infective Therapy, Journal Year: 2022, Volume and Issue: 20(6), P. 897 - 906

Published: Feb. 19, 2022

Mitigation of infectious diseases resulted from antibiotic-resistant bacteria is difficult by current antibiotics. Metal and metal oxide nanoparticles specifically Ag can be efficient antibacterial agents considering their biocompatibility. In this way, biosynthesis living organisms or metabolites has obtained more attention compared to chemical physical methods.Bacteria fungi in extracellular intracellular pathways related primary secondary synthesize with synergistic activity against bacterial pathogens.Bacteriostatic bactericidal effects these lead production reactive oxygen species inactivation biological macromolecules such as proteins nucleic acids. The present review tried discuss recent progress challenges about mechanisms bio-inspired archaebacteria, actinomycetes, cyanobacteria, fungi.

Language: Английский

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Millets: sustainable treasure house of bioactive components

International Journal of Food Properties, Journal Year: 2023, Volume and Issue: 26(1), P. 1822 - 1840

Published: July 19, 2023

Food security has become a major issue around the globe. Even today food is not accessible to every person of this world. United Nations set target for everyone by 2030, but still, we are very far away from target. Millets four season crop, which cultivated globally post-green revolution era, their cultivation significantly declined due more accentuation on rice, wheat and maize. The primary suppliers carbohydrates humanity dependent lack essential amino acids minerals cardinal proper nutrition. This nutrients in diet lifestyles welcomes numerous diseases like cardiovascular diseases, obesity diabetes. unique richness dietary fibers, antioxidants, protein, fats. present global spectacle climate alternate forced us sustain our natural resources. In case, millets ones that poor soils. review article reviews beneficiaries millet contrast human health as certain polyphenols catechin, sinapic acid, found have many sustaining benefits prevention against arthritis, cancer, inflammation, environment compared staple grains minimum water requirement, less fertile soils, usage pesticides fertilizers provides nurturing ecosystem. incorporation into daily an individual might help curing complications.

Language: Английский

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Unveiling novel features and phylogenomic assessment of indigenous Priestia megaterium AB-S79 using comparative genomics

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

ABSTRACT Priestia megaterium strain AB-S79 isolated from active gold mine soil previously expressed in vitro heavy metal resistance and has a 5.7 Mb genome useful for biotechnological exploitation. This study used web-based bioinformatic resources to analyze P. genomic relatedness, decipher its secondary metabolite biosynthetic gene clusters (BGCs), better comprehend taxa. Genes were highly conserved across the 14 P . genomes examined here. The pangenome reflected total of 61,397 protein-coding genes, 59,745 homolog protein family hits, 1,652 singleton hits. There also 7,735 families, including 1,653 families 6,082 families. OrthoVenn3 comparison sequences with 13 other strains, 7 spp., 6 Bacillus spp. highlighted AB-S79’s unique evolutionary trait. antiSMASH identified two key transcription factor binding site regulators genome: zinc-responsive repressor (Zur) antibiotic production activator (AbrC3), plus putative enzymes biosynthesis terpenes ranthipeptides. harbors BGCs siderophores (synechobactins schizokinens), phosphonate, dienelactone hydrolase protein, phenazine (phzF), which is significant this study. Phosphonate particularly showed specificity sp. validating effect expansion contraction. looks be viable source value-added compounds. Thus, contributes theoretical framework systematic metabolic genetic exploitation sp., value-yielding strains. IMPORTANCE explores microbial natural product discovery using mining, focusing on Key findings highlight potential , AB-S79, applications. research shows limited output Africa, emphasizing importance native AB-S79. Additionally, underlines strain’s diverse capabilities, reinforcing suitability as model cell factories foundational role future

Language: Английский

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Current Trends in Microbial Biotechnology for Agricultural Sustainability: Conclusion and Future Challenges

Environmental and microbial biotechnology, Journal Year: 2020, Volume and Issue: unknown, P. 555 - 572

Published: Nov. 10, 2020

Language: Английский

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Endophytic fungal communities and their biotechnological implications for agro-environmental sustainability

Folia Microbiologica, Journal Year: 2022, Volume and Issue: 67(2), P. 203 - 232

Published: Feb. 4, 2022

Language: Английский

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Towards further understanding the applications of endophytes: enriched source of bioactive compounds and bio factories for nanoparticles

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: July 10, 2023

The most significant issues that humans face today include a growing population, an altering climate, reliance on pesticides, the appearance of novel infectious agents, and accumulation industrial waste. production agricultural goods has also been subject to great number shifts, often known as revolutions, which have influenced by progression civilization, technology, general human advancement. Sustainable measures can be applied in agriculture, environment, medicine, industry are needed lessen harmful effects aforementioned problems. Endophytes, might bacterial or fungal, could successful solution. They protect plants promote growth producing phytohormones providing biotic abiotic stress tolerance. Endophytes produce diverse type bioactive compounds such alkaloids, saponins, flavonoids, tannins, terpenoids, quinones, chinones, phenolic acids etc. for various therapeutic advantages anticancer, antitumor, antidiabetic, antifungal, antiviral, antimicrobial, antimalarial, antioxidant activity. Proteases, pectinases, amylases, cellulases, xylanases, laccases, lipases, other types enzymes vital many different industries produced endophytes. Due presence all these endophytes, they preferred sources green synthesis nanoparticles. This review aims comprehend contributions uses endophytes medicinal, sectors bio-nanotechnology with their mechanism action.

Language: Английский

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