Nanophotonics,
Journal Year:
2021,
Volume and Issue:
10(12), P. 3089 - 3134
Published: Sept. 2, 2021
Abstract
Cancer
is
the
second
leading
cause
of
death
worldwide
after
cardiovascular
disease.
Depending
on
type
and
location
tumor,
several
cancer
treatments
are
implemented.
Among
these,
three
most
conventional
therapies
surgery,
radiotherapy
chemotherapy.
However,
there
other
therapeutic
approaches
such
as
photodynamic
therapy
(PDT).
PDT
relies
combined
action
light,
a
photoactivable
molecule
called
photosensitizer
(PS)
molecular
oxygen.
Most
PSs
used
for
clinical
applications
not
cancer-cell
specific.
One
solutions
to
overcome
this
problem
use
nanoparticles
(NPs)
induce
passive
targeting.
It
also
possible
graft
vector
onto
NPs
specifically
target
membrane
receptors
overexpressed
in
tumor
cells
or
neovessels
surrounding
tumor.
In
review,
we
focus
loaded
with
coupled
peptides
targeted
PDT.
We
described
nanosystems
that
Neuropilin-1
(NRP-1),
α
v
β
3
integrins,
nucleolin
receptor,
epidermal
growth
factor
(EGF)
protein-glutamine-gamma-glutamyltransferase
(TGM2),
p32,
transferrin,
PD-1,
mitochondrial
membrane.
The
cell
absorbing-peptide
described.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
169, P. 115891 - 115891
Published: Nov. 16, 2023
Lung
cancer
accounts
for
a
relatively
high
proportion
of
malignant
tumors.
As
the
most
prevalent
type
lung
cancer,
non-small
cell
(NSCLC)
is
characterized
by
morbidity
and
mortality.
Presently,
arsenal
treatment
strategies
encompasses
surgical
resection,
chemotherapy,
targeted
therapy
radiotherapy.
However,
despite
these
options,
prognosis
remains
distressingly
poor
with
low
5-year
survival
rate.
Therefore,
it
urgent
to
pursue
paradigm
shift
in
methodologies.
In
recent
years,
advent
sophisticated
biotechnologies
interdisciplinary
integration
has
provided
innovative
approaches
cancer.
This
article
reviews
cutting-edge
developments
nano
drug
delivery
system,
molecular
photothermal
strategy,
immunotherapy
Overall,
systematically
summarizing
critically
analyzing
latest
progress
current
challenges
we
aim
provide
theoretical
basis
development
novel
drugs
treatment,
thus
improve
therapeutic
outcomes
patients.
Coordination Chemistry Reviews,
Journal Year:
2023,
Volume and Issue:
495, P. 215350 - 215350
Published: Aug. 19, 2023
Innovative
anticancer
therapies
based
on
the
activation
of
immune
system
offer
promise
in
battle
against
cancers
resistant
to
traditional
treatments.
Examples
such
therapeutic
approaches
include,
along
with
various
types
immunotherapies,
photodynamic
therapy
(PDT).
PDT
is
a
photochemistry-based
strategy
that
results
not
only
from
its
direct
effects
cancer
cells
but
also
disruption
tumor
vasculature
and
host
system.
However,
achieve
success
manifested
eradication
primary
distant
metastases,
it
necessary
design
suitable
photosensitizers
(PSs)
desired
optical
photophysical
properties
enable
efficient
generation
ROS
under
microenvironmental
(TME)
conditions,
especially
hypoxia.
Thus,
this
review
particular
attention
paid
photochemical
PSs,
notably
sufficiently
long-lived
triplet
states
mechanisms
energy/electron
transfer
reactions.
Photogenerated
initiate
inflammatory
reaction,
expression
heat-shock
proteins,
infiltration
long-term
memory.
These
unique
features
give
new
possibilities
combine
agents
stimulating
response
as
well
immunotherapy,
PD-1/PD-L1
blockade.
Most
systems
explored
aspect
so
far
are
either
derivatives
naturally
occurring
metal
complexes
(Heme,
Chlorophyll
a,
Bacteiochorophyll
-
inspired
PSs),
synthetic
(metallo)porphyrins,
(metallo)phthalocyanines
or
hybrid
materials
containing
nanoparticles.
This
work
summarizes
recent
reports
synthesis
antibody-PS
conjugates
spectroscopic
enhanced
selectivity
biological
activity.
Finally,
most
notable
drawbacks
presented,
scenario
outlined
for
development
alone,
combined
immunotherapy
overcome
these
challenges
future.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(7)
Published: Nov. 25, 2021
To
promote
the
clinical
theranostic
performances
of
platinum-based
anticancer
drugs,
imaging
capability
is
urgently
desired,
and
their
chemotherapeutic
efficacy
needs
to
be
upgraded.
Herein,
a
metallacycle
(M)
developed
for
imaging-guided
cancer
radio-chemotherapy
using
perylene
bisimide
fluorophore
(PPy)
tetraphenylethylene-based
di-Pt(II)
organometallic
precursor
(TPE-Pt)
as
building
blocks.
The
formation
this
discrete
supramolecular
coordination
complex
facilitates
encapsulation
M
by
glutathione
(GSH)-responsive
amphiphilic
block
copolymer
prepare
M-loaded
nanoparticles
(MNPs).
TPE-Pt
acts
drug
also
an
excellent
radiosensitizer,
thus
incorporating
radiotherapy
into
nanomedicine
accelerate
therapeutic
overcome
resistance.
NIR-emission
PPy
employed
detect
intracellular
delivery
tissue
distribution
MNPs
in
real
time.
In
vitro
vivo
investigations
demonstrate
combining
chemotherapy
radiotherapy;
administration
effectively
inhibits
tumor
growth
greatly
extends
survival
rate
cisplatin-resistant
A2780CIS-tumor-bearing
mice.
Guided
fluorescence
imaging,
precisely
carried
out,
which
boosting
outcomes
minimizing
undesired
side
effects.
success
system
brings
new
hope
nanomedicines
potential
translations.
ACS Omega,
Journal Year:
2022,
Volume and Issue:
7(50), P. 45882 - 45909
Published: Dec. 6, 2022
The
clinical
need
for
photodynamic
therapy
(PDT)
has
been
growing
several
decades.
Notably,
PDT
is
often
used
in
oncology
to
treat
a
variety
of
tumors
since
it
low-risk
with
excellent
selectivity,
does
not
conflict
other
therapies,
and
may
be
repeated
as
necessary.
mechanism
action
the
photoactivation
particular
photosensitizer
(PS)
tumor
microenvironment
presence
oxygen.
During
PDT,
cancer
cells
produce
singlet
oxygen
(1O2)
reactive
species
(ROS)
upon
activation
PSs
by
irradiation,
which
efficiently
kills
tumor.
However,
PDT's
effectiveness
curing
deep-seated
malignancy
constrained
three
key
reasons:
tumor's
inadequate
PS
accumulation
tissues,
hypoxic
core
low
content
solid
tumors,
limited
depth
light
penetration.
PDTs
are
therefore
restricted
management
thin
superficial
cancers.
With
development
nanotechnology,
ability
penetrate
deep
tissues
exert
desired
therapeutic
effects
become
reality.
further
advancement
this
field
research
necessary
address
challenges
ameliorate
outcome.
This
review
presents
an
overview
PSs,
loading
nanomedicine-based
solutions
enhancing
their
biological
applications
including
chemodynamic
therapy,
chemo-photodynamic
PDT-electroporation,
photodynamic-photothermal
(PDT-PTT)
PDT-immunotherapy.
Furthermore,
discusses
ROS
generation
advantages
PDT.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: July 1, 2022
Abstract
Cancer
is
one
of
the
significant
threats
to
human
life.
Although
various
latest
technologies
are
currently
available
treat
cancer,
it
still
accounts
for
millions
death
each
year
worldwide.
Thus,
creating
a
need
more
developed
and
novel
combat
this
deadly
condition.
Nanoparticles-based
cancer
therapeutics
have
offered
promising
approach
effectively
while
minimizing
adverse
events.
Among
nanoparticles,
nanogold
(AuNPs)
biocompatible
proved
their
efficiency
in
treating
because
they
can
reach
tumors
via
enhanced
permeability
retention
effect.
The
size
shape
AuNPs
responsible
diverse
therapeutic
behavior.
modulate
values,
be
synthesized
shapes,
such
as
spheres,
cages,
flowers,
shells,
prisms,
rods,
clusters,
etc.
Also,
attaching
with
single
or
multiple
targeting
agents
facilitate
active
tumor
tissue.
been
much
explored
photothermal
therapy
(PTT)
cancer.
In
addition
PTT,
AuNPs-based
nanoplatforms
investigated
combinational
multimodal
therapies
last
few
years,
including
photodynamic
therapy,
chemotherapy,
radiotherapy,
immunotherapy,
etc.,
ablate
cells.
present
review
focuses
on
recent
advancements
functionalization
nanoconstructs
imaging
using
combinatorial
approaches
cancers.
Graphical
Cancers,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3918 - 3918
Published: Aug. 1, 2023
Over
the
last
20
years,
gliomas
have
made
up
over
89%
of
malignant
CNS
tumor
cases
in
American
population
(NIH
SEER).
Within
this,
glioblastoma
is
most
common
subtype,
comprising
57%
all
glioma
cases.
Being
highly
aggressive,
this
deadly
disease
known
for
its
high
genetic
and
phenotypic
heterogeneity,
rendering
a
complicated
course.
The
current
standard
care
consists
maximally
safe
resection
concurrent
with
chemoradiotherapy.
However,
despite
advances
technology
therapeutic
modalities,
rates
recurrence
are
still
survivability
remains
low.
Given
delicate
nature
location,
remaining
margins
following
often
initiate
recurrence.
Photodynamic
therapy
(PDT)
modality
that,
administration
non-toxic
photosensitizer,
induces
tumor-specific
anti-cancer
effects
after
localized,
wavelength-specific
illumination.
Its
effect
against
has
been
studied
extensively
30
pre-clinical
clinical
trials.
Here,
we
provide
comprehensive
review
three
generations
photosensitizers
alongside
their
mechanisms
action,
limitations,
future
directions.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(11), P. 1972 - 1972
Published: Nov. 20, 2021
Lung
cancer
is
a
significant
health
problem
worldwide.
Unfortunately,
current
therapeutic
strategies
lack
sufficient
level
of
specificity
and
can
harm
adjacent
healthy
cells.
Consequently,
to
address
the
clinical
need,
novel
approaches
improve
treatment
efficiency
with
minimal
side
effects
are
required.
Nanotechnology
substantially
contribute
generation
differentiated
products
patient
outcomes.
Evidence
from
previous
research
suggests
that
nanotechnology-based
drug
delivery
systems
could
provide
promising
platform
for
targeted
traditional
chemotherapeutic
drugs
small
molecule
agents
treat
lung
cells
more
effectively.
This
has
also
been
found
index
reduce
required
dose.
Nanodrug
precise
control
over
release,
resulting
in
reduced
toxic
effects,
controlled
biodistribution,
accelerated
or
responses.
review
highlights
most
advanced
strategies,
including
nanodrug
systems,
stimuli-responsive
nanoparticles,
bio-nanocarriers,
which
have
recently
employed
preclinical
investigations
overcome
challenges
treatments.
