Polymers,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1123 - 1123
Published: Feb. 23, 2023
In
the
last
few
decades,
several
natural
bioactive
agents
have
been
widely
utilized
in
treatment
and
prevention
of
many
diseases
owing
to
their
unique
versatile
therapeutic
effects,
including
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective
action.
However,
poor
aqueous
solubility,
bioavailability,
low
GIT
stability,
extensive
metabolism
as
well
short
duration
action
are
most
shortfalls
hampering
biomedical/pharmaceutical
applications.
Different
drug
delivery
platforms
developed
this
regard,
a
captivating
tool
has
fabrication
nanocarriers.
particular,
polymeric
nanoparticles
were
reported
offer
proficient
various
with
good
entrapment
potential
an
efficiently
controlled
release,
improved
fascinating
efficacy.
addition,
surface
decoration
polymer
functionalization
opened
door
improving
characteristics
alleviating
toxicity.
Herein,
review
state
knowledge
on
loaded
is
presented.
The
focuses
frequently
used
materials
corresponding
methods
fabrication,
needs
such
systems
for
agents,
literature,
role
functionalization,
hybrid
systems,
stimuli-responsive
overcoming
system
drawbacks.
This
exploration
may
thorough
idea
viewing
candidate
challenges
combating
tools
overcome
any
hurdles.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(3)
Published: Sept. 6, 2021
Skin
penetration
of
active
molecules
for
treatment
diverse
diseases
is
a
major
field
research
owing
to
the
advantages
associated
with
skin
like
easy
accessibility,
reduced
systemic-derived
side
effects,
and
increased
therapeutic
efficacy.
Despite
these
advantages,
dermal
drug
delivery
generally
challenging
due
low
permeability
therapeutics.
Although
various
methods
have
been
developed
improve
permeation
therapeutics,
they
are
usually
aggressive
could
lead
irreversible
damage
stratum
corneum.
Nanosized
carrier
systems
represent
an
alternative
approach
current
technologies,
minimal
natural
barrier
function
skin.
In
this
Review,
use
nanoparticles
deliver
molecules,
genetic
material,
vaccines
into
discussed.
addition,
nanotoxicology
studies
recent
clinical
development
highlighted
shed
light
on
their
potential
undergo
market
translation.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Advances in Colloid and Interface Science,
Journal Year:
2023,
Volume and Issue:
314, P. 102871 - 102871
Published: March 9, 2023
Nanotechnological
drug
delivery
platforms
represent
a
new
paradigm
for
cancer
therapeutics
as
they
improve
the
pharmacokinetic
profile
and
distribution
of
chemotherapeutic
agents
over
conventional
formulations.
Among
nanoparticles,
lipid-based
nanoplatforms
possessing
lipid
core,
that
is,
lipid-core
nanoparticles
(LCNPs),
have
gained
increasing
interest
due
to
properties
such
high
solubilizing
potential,
versatility,
biocompatibility,
biodegradability.
However,
wide
spectrum
morphologies
types
LCNPs,
there
is
lack
consensus
regarding
their
terminology
classification.
According
current
state-of-the-art
in
this
critical
review,
LCNPs
are
defined
classified
based
on
state
lipidic
components
liquid
(LLNs).
These
include
nanoemulsions
(LNEs)
nanocapsules
(LNCs),
solid
(SLNs)
nanostructured
nanocarriers
(NLCs).
In
addition,
we
present
comprehensive
comparative
description
methods
employed
preparation,
routes
administration
fundamental
role
physicochemical
efficient
antitumoral
drug-delivery
application.
Market
available
clinical
trials
preclinical
vivo
studies
promising
potential
treatments
different
pathologies
summarized.
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 7, 2024
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
