Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: March 29, 2024
Abstract
The
deployment
of
imaging
examinations
has
evolved
into
a
robust
approach
for
the
diagnosis
lymph
node
metastasis
(LNM).
advancement
technology,
coupled
with
introduction
innovative
drugs,
led
to
incorporation
an
increasingly
diverse
array
techniques
clinical
practice.
Nonetheless,
conventional
methods
administering
agents
persist
in
presenting
certain
drawbacks
and
side
effects.
employment
controlled
drug
delivery
systems
(DDSs)
as
conduit
transporting
offers
promising
solution
ameliorate
these
limitations
intrinsic
metastatic
(LN)
imaging,
thereby
augmenting
diagnostic
precision.
Within
scope
this
review,
we
elucidate
historical
context
LN
encapsulate
frequently
employed
DDSs
conjunction
variety
techniques,
specifically
imaging.
Moreover,
engage
discourse
on
conceptualization
practical
application
fusing
treatment
by
employing
DDSs.
Finally,
venture
prospective
applications
realm
LNM
share
our
perspective
potential
trajectory
DDS
development.
Graphical
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 9, 2023
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
Vaccines,
Journal Year:
2021,
Volume and Issue:
9(4), P. 359 - 359
Published: April 8, 2021
COVID-19
vaccines
have
been
developed
with
unprecedented
speed
which
would
not
possible
without
decades
of
fundamental
research
on
delivery
nanotechnology.
Lipid-based
nanoparticles
played
a
pivotal
role
in
the
successes
and
many
other
nanomedicines,
such
as
Doxil
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5977 - 6039
Published: Feb. 2, 2022
The
stimulator
of
interferon
genes
(STING)
cellular
signaling
pathway
is
a
promising
target
for
cancer
immunotherapy.
Activation
the
intracellular
STING
protein
triggers
production
multifaceted
array
immunostimulatory
molecules,
which,
in
proper
context,
can
drive
dendritic
cell
maturation,
antitumor
macrophage
polarization,
T
priming
and
activation,
natural
killer
vascular
reprogramming,
and/or
death,
resulting
immune-mediated
tumor
elimination
generation
immune
memory.
Accordingly,
there
significant
amount
ongoing
preclinical
clinical
research
toward
further
understanding
role
surveillance
as
well
development
modulators
strategy
to
stimulate
immunity.
Yet,
efficacy
agonists
limited
by
many
drug
delivery
pharmacological
challenges.
Depending
on
class
agonist
desired
administration
route,
these
may
include
poor
stability,
immunocellular
toxicity,
immune-related
adverse
events,
or
lymph
node
targeting
retention,
low
uptake
delivery,
complex
dependence
magnitude
kinetics
signaling.
This
review
provides
concise
summary
pathway,
highlighting
recent
biological
developments,
immunological
consequences,
implications
delivery.
also
offers
critical
analysis
an
expanding
arsenal
chemical
strategies
that
are
being
employed
enhance
efficacy,
safety,
utility
lastly
draws
attention
several
opportunities
therapeutic
advancements.
Small,
Journal Year:
2022,
Volume and Issue:
18(36)
Published: April 9, 2022
Abstract
Nanoparticles
(NPs)
have
attracted
tremendous
interest
in
drug
delivery
the
past
decades.
Microfluidics
offers
a
promising
strategy
for
making
NPs
due
to
its
capability
precisely
controlling
NP
properties.
The
recent
success
of
mRNA
vaccines
using
microfluidics
represents
big
milestone
microfluidic
pharmaceutical
applications,
and
rapid
scaling
up
demonstrates
feasibility
industrial‐scale
manufacturing.
This
article
provides
critical
review
progress
delivery.
First,
synthesis
organic
focusing
on
typical
methods
their
applications
popular
clinically
relevant
NPs,
such
as
liposomes,
lipid
polymer
well
mechanisms
are
summarized.
Then,
several
representative
inorganic
(e.g.,
silica,
metal,
metal
oxide,
quantum
dots),
hybrid
is
discussed.
Lastly,
various
presented.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(6)
Published: Dec. 25, 2022
Abstract
Nano‐immunotherapy
has
been
recognized
as
a
highly
promising
strategy
for
cancer
treatment
in
recent
decades,
which
combines
nanotechnology
and
immunotherapy
to
combat
against
tumors.
Hybrid
nanomaterials
consisting
of
at
least
two
constituents
with
distinct
compositions
properties,
usually
organic
inorganic,
have
engineered
integrated
functions
enormous
potential
boosting
immunotherapy.
This
review
provides
summary
hybrid
reported
immunotherapy,
including
nanoscale
metal–organic
frameworks,
metal–phenolic
networks,
mesoporous
organosilica
nanoparticles,
metallofullerene
nanomaterials,
polymer–lipid,
biomacromolecule‐based
nanomaterials.
The
combination
chemotherapy,
chemodynamic
therapy,
radiotherapy,
radiodynamic
photothermal
photodynamic
sonodynamic
therapy
based
on
is
also
discussed.
Finally,
the
current
challenges
prospects
designing
their
application
are
outlined.
Nano-Micro Letters,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: June 3, 2023
Abstract
Immunotherapy
has
become
a
promising
research
“hotspot”
in
cancer
treatment.
“Soldier”
immune
cells
are
not
uniform
throughout
the
body;
they
accumulate
mostly
organs
such
as
spleen
and
lymph
nodes
(LNs),
etc.
The
unique
structure
of
LNs
provides
microenvironment
suitable
for
survival,
activation,
proliferation
multiple
types
cells.
play
an
important
role
both
initiation
adaptive
immunity
generation
durable
anti-tumor
responses.
Antigens
taken
up
by
antigen-presenting
peripheral
tissues
need
to
migrate
with
lymphatic
fluid
activate
lymphocytes
therein.
Meanwhile,
accumulation
retaining
many
functional
compounds
enhance
their
efficacy
significantly.
Therefore,
have
key
target
tumor
immunotherapy.
Unfortunately,
nonspecific
distribution
drugs
vivo
greatly
limits
activation
cells,
which
leads
unsatisfactory
effects.
efficient
nano-delivery
system
is
effective
strategy
maximize
drugs.
Nano-delivery
systems
shown
beneficial
improving
biodistribution
enhancing
lymphoid
tissues,
exhibiting
powerful
prospects
achieving
delivery
LNs.
Herein,
physiological
barriers
were
summarized
factors
affecting
discussed
thoroughly.
Moreover,
developments
reviewed
transformation
targeting
nanocarriers
discussed.
