Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

Bioactive Materials, Journal Year: 2021, Volume and Issue: 8, P. 220 - 240

Published: July 6, 2021

The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering "all-in-one" functional platform features. However, the native defects limit delivery release behavior throughout in vivo journey, which significantly compromise therapeutic efficacy hinder further cancer treatment. In this review, we summarized discussed recent strategies enhance drug for improved therapy, including optimizing intrinsic physicochemical properties external modification. Finally, corresponding challenges that faced are future perspectives its application presented. We hope review will provide constructive information rational design more effective advance

Language: Английский

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Versatile polyphenolic platforms in regulating cell biology

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(10), P. 4175 - 4198

Published: Jan. 1, 2022

Polyphenolic materials are a class of fascinating and versatile bioinspired for biointerfacial engineering. In particular, due to the presence active chemical groups, series unique physicochemical properties become accessible tunable as-prepared polyphenolic platforms, which could delicately regulate cell activities via cell-material contact-dependent interactions. More interestingly, polyphenols also affect behaviors contact-independent manner, arise their intrinsically functional characteristics (e.g., antioxidant photothermal behaviors). As such, comprehensive understanding on relationship between material desired biomedical applications, as well underlying mechanism at cellular molecular level would provide design principles accelerate lab-to-clinic translation platforms. this review, we firstly give brief overview hallmarks governed by surrounding cues, followed introduction engineering strategies. Subsequently, detailed discussion cell-polyphenols interfacial interaction was carefully provided. Lastly, applications were elaborated. We believe that review guidances rational multifunctional extend application window.

Language: Английский

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White Blood Cell Membrane‐Coated Nanoparticles: Recent Development and Medical Applications

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 11(7)

Published: Aug. 31, 2021

White blood cells (WBCs) are immune that play essential roles in critical diseases including cancers, infections, and inflammatory disorders. Their dynamic diverse functions have inspired the development of WBC membrane-coated nanoparticles (denoted "WBC-NPs"), which formed by fusing plasma membranes WBCs, such as macrophages, neutrophils, T cells, natural killer onto synthetic nanoparticle cores. Inheriting entire source cell antigens, WBC-NPs act decoys simulate their broad biointerfacing properties with intriguing therapeutic potentials. Herein, recent medical applications focusing on four areas, carriers for drug delivery, countermeasures biological neutralization, nanovaccines modulation, tools isolation circulating tumor fundamental research is reviewed. Overall, studies established platform versatile nanotherapeutics application

Language: Английский

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Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 341, P. 227 - 246

Published: Nov. 22, 2021

Language: Английский

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A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

Science Advances, Journal Year: 2021, Volume and Issue: 7(6)

Published: Feb. 5, 2021

Nanoparticle-based drug delivery faces challenges from the imprecise targeted and low bioavailability of drugs due to complex biological barriers. Here, we designed cascade-targeting, dual drug-loaded, core-shell nanoparticles (DLTPT) consisting CD44-targeting hyaluronic acid shells decorated with doxorubicin (HA-DOX) mitochondria-targeting triphenylphosphonium derivative nanoparticle cores loaded lonidamine (LND) dimers (LTPT). DLTPT displayed prolonged blood circulation time efficiently accumulated at tumor site tumor-homing effect negatively charged acid. Subsequently, HA-DOX shell was degraded by extracellular hyaluronidase, resulting in decreased particle size negative-to-positive charge reversal, which would increase penetration internalization. The degradation further accelerated release DOX exposed positively LTPT core for rapid endosomal escape mitochondria-targeted LND. Notably, when used combination anti-PD-L1, growth inhibited, induced immune response against metastasis.

Language: Английский

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Nanoparticle-based medicines in clinical cancer therapy

Nano Today, Journal Year: 2022, Volume and Issue: 45, P. 101512 - 101512

Published: June 4, 2022

Language: Английский

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Towards principled design of cancer nanomedicine to accelerate clinical translation

Materials Today Bio, Journal Year: 2022, Volume and Issue: 13, P. 100208 - 100208

Published: Jan. 1, 2022

Nanotechnology in medical applications, especially oncology as drug delivery systems, has recently shown promising results. However, although these advances have been the pre-clinical stages, clinical translation of this technology is challenging. To create systems with increased treatment efficacy for translation, physicochemical characteristics nanoparticles such size, shape, elasticity (flexibility/rigidity), surface chemistry, and charge can be specified to optimize efficiency a given application. Consequently, interdisciplinary researchers focused on producing biocompatible materials, production technologies, or new formulations efficient loading, high stability. The effects design parameters studied

Language: Английский

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Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies

Theranostics, Journal Year: 2022, Volume and Issue: 12(3), P. 1030 - 1060

Published: Jan. 1, 2022

Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery distribution of drugs within pancreatic compromised due to intrinsic physical biochemical stresses that lead increased interstitial fluid pressure, vascular compression, hypoxia. Immunotherapy-based approaches, including therapeutic vaccines, immune checkpoint inhibition, CAR-T cell therapy, adoptive T therapies, challenged by an immunosuppressive tumor microenvironment. Together, extensive fibrosis immunosuppression present major challenges developing treatments for cancer. In this context, nanoparticles have been extensively studied as delivery platforms adjuvants cancer other disease therapies. Recent advances in nanotechnology led the development multiple nanocarrier-based formulations not only improve drug but also enhance immunotherapy-based approaches This review discusses critically analyzes novel nanoscale strategies used immunomodulation treatment efficacy, newly emerging approaches. presents important perspectives on future research directions will guide rational design robust treat tumors, particularly with respect targeted therapies immunotherapies. These insights inform next generation clinical help patients manage debilitating survival rates.

Language: Английский

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Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 5, 2023

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.

Language: Английский

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Smart stimuli-responsive injectable gels and hydrogels for drug delivery and tissue engineering applications: A review

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 22, 2023

Hydrogels are widely used biomaterials in the delivery of therapeutic agents, including drugs, genes, proteins, etc., as well tissue engineering, due to obvious properties such biocompatibility and their similarity natural body tissues. Some these substances have feature injectability, which means that substance is injected into desired place solution state then turns gel, makes it possible administer them from a way with minimal amount invasion eliminate need for surgery implant pre-formed materials. Gelation can be caused by stimulus and/or spontaneously. Suppose this induces effect one or many stimuli. In case, material question called stimuli-responsive because responds surrounding conditions. context, we introduce different stimuli cause gelation investigate mechanisms transformation gel them. Also, study special structures, nano gels nanocomposite gels.

Language: Английский

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