Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 75, P. 103631 - 103631
Published: July 31, 2022
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 25, 2023
Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.
Language: Английский
Citations
598
Ultrasonics Sonochemistry, Journal Year: 2021, Volume and Issue: 78, P. 105686 - 105686
Published: July 27, 2021
Quercetin (QUR) have got the attention of scientific society frequently due to their wide range potential applications. QUR has been focal point for research in various fields, especially food development. But, is highly unstable and can be interrupted by using conventional assessment methods. Therefore, researchers are focusing on novel extraction non-invasive tools non-destructive QUR. The current review elaborates different (ultrasound-assisted extraction, microwave-assisted supercritical fluid enzyme-assisted extraction) techniques (fluorescence spectroscopy, terahertz near-infrared hyperspectral imaging, Raman surface-enhanced spectroscopy) identification agricultural products. approaches facilitate shorter time, involve less organic solvent, environmentally friendly. While non-interruptive, label-free, reliable, accurate, environmental spectroscopic imaging methods suitable sensitive detection bioactive compounds than techniques. therapeutic properties such as anti-obesity, anti-diabetes, antiallergic, antineoplastic agent, neuroprotector, antimicrobial, antioxidant activities. Besides, low bioavailability innovative drug delivery strategies (QUR loaded gel, polymeric micelle, nanoparticles, glucan-QUR conjugate, mucoadhesive nanoemulsions) proposed improve its providing approaches.
Language: Английский
Citations
112
RSC Advances, Journal Year: 2023, Volume and Issue: 13(13), P. 8606 - 8629
Published: Jan. 1, 2023
Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.
Language: Английский
Citations
105
Science Advances, Journal Year: 2022, Volume and Issue: 8(25)
Published: June 22, 2022
Interleukin-11 (IL-11) is a profibrotic cytokine essential for the differentiation of fibroblasts into collagen-secreting, actin alpha 2, smooth muscle-positive (ACTA2+) myofibroblasts, driving processes underlying pathogenesis idiopathic pulmonary fibrosis (IPF). Here, we developed an inhalable and mucus-penetrative nanoparticle (NP) system incorporating siRNA against IL11 (siIL11@PPGC NPs) investigated therapeutic potential treatment IPF. NPs are formulated through self-assembly biodegradable PLGA-PEG diblock copolymer self-created cationic lipid-like molecule G0-C14 to enable efficient transmucosal delivery siIL11. Noninvasive aerosol inhalation hindered fibroblast reduced ECM deposition via inhibition ERK SMAD2. Furthermore, siIL11@PPGC significantly diminished development improved function in mouse model bleomycin-induced without inducing systemic toxicity. This work presents versatile NP platform locally inhaled therapeutics exhibits promising clinical numerous respiratory diseases, including
Language: Английский
Citations
101
International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 632, P. 122570 - 122570
Published: Dec. 29, 2022
Language: Английский
Citations
94
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 207 - 207
Published: Jan. 6, 2023
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol phospholipids. Recently, liposomes have been widely administered intranasally for systemic brain delivery. From the nasal cavity, liposome-encapsulated drugs genes enter circulation primarily via absorption in respiratory region, whereas they can be directly transported to olfactory pathway. protect enzymatic degradation, increase drug across epithelium, prolong residence time cavity. Intranasal also a potential approach vaccine used as platform load antigens adjuvants induce robust immune response. With recent interest intranasal liposome formulations, this review discusses various aspects of that make them suitable administration. We summarized latest advancements applications evaluated their performance delivery intranasally. reviewed advances development proposed perspectives on future liposomes.
Language: Английский
Citations
58
Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1023 - 1023
Published: Feb. 6, 2023
As the world's most prevalent cancer, breast cancer imposes a significant societal health burden and is among leading causes of death in women worldwide. Despite notable improvements survival countries with early detection programs, combined different modes treatment to eradicate invasive disease, current chemotherapy regimen faces challenges associated chemotherapy-induced side effects development drug resistance. Therefore, serious concerns regarding chemotherapeutics are pressuring researchers develop alternative therapeutics better efficacy safety. Due their extremely biocompatible nature efficient destruction cells via numerous mechanisms, phytochemicals have emerged as one attractive therapies for treat cancer. Additionally, phytofabricated nanocarriers, whether used alone or conjunction other loaded phytotherapeutics chemotherapeutics, showed promising results treating In review, we emphasize anticancer activity phytochemical-instigated nanocarriers phytochemical-loaded against both vitro vivo. Since diverse mechanisms implicated phytochemicals, strong emphasis placed on pathways underlying action. Furthermore, discuss selective targeted delivery consider research gaps, recent developments, druggability phytoceuticals. Combining phytochemical chemotherapeutic agents nanotechnology might far-reaching impacts future.
Language: Английский
Citations
57
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15764 - 15764
Published: Oct. 30, 2023
Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability encapsulated compounds but also provide efficient targeting reduce risk toxicity. Over last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, herbs have received more attention due their remarkable biological pharmacological health medical benefits. However, poor aqueous solubility, compromised stability, insufficient absorption, accelerated elimination impede research in nutraceutical sector. Owing possibilities offered by various LNPs, ability accommodate both hydrophilic hydrophobic molecules availability preparation methods suitable for sensitive molecules, loading natural fragile into LNPs offers a promising solution. The primary objective this work is explore synergy between nature nanotechnology, encompassing wide range aimed at encapsulating therapeutic within LNPs.
Language: Английский
Citations
47
Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122616 - 122616
Published: April 8, 2024
Language: Английский
Citations
22
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 864 - 878
Published: Jan. 27, 2024
Language: Английский
Citations
19