Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine DOI Creative Commons
Shihab Uddin, Rafiqul Islam, Rahman Md Moshikur

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 2969 - 2969

Published: March 27, 2023

Transcutaneous vaccination is one of the successful, affordable, and patient-friendly advanced immunization approaches because presence multiple immune-responsive cell types in skin. However, absence a preferable facilitator, skin's outer layer strong impediment to delivering biologically active foreign particles. Lipid-based biocompatible ionic-liquid-mediated nanodrug carriers represent an expedient distinct strategy permit transdermal drug delivery; with acceptable surfactants, performance formulations might be further enhanced. For this purpose, we formulated lipid-based nanovaccine using conventional (cationic/anionic/nonionic) surfactant loaded antigenic protein immunomodulator its core promote delivery by penetrating skin boosting immunogenic activity. In follow-up investigation, freeze-dry emulsification process was used prepare nanovaccine, delivery, pharmacokinetic parameters, ability activate autoimmune cells tumor microenvironment were studied tumor-budding C57BL/6N mouse model. These analyses performed ELISA, nuclei HE staining, flow cytometry, other biological techniques. The immunomodulator-containing significantly (p < 0.001) increased anticancer immune responses (IgG, IgG1, IgG2, CD8+, CD207+, CD103+ expression) without causing cellular or toxicity. Using nanovaccination approach, it possible create more targeted efficient system for cancer antigens, thereby stimulating stronger response compared aqueous formulations. This lead effective therapeutic preventative outcomes patients cancer.

Language: Английский

Targeting strategies for mRNA delivery DOI Creative Commons

Randall A. Meyer,

Sarah Y. Neshat, Jordan J. Green

et al.

Materials Today Advances, Journal Year: 2022, Volume and Issue: 14, P. 100240 - 100240

Published: April 12, 2022

mRNA gene therapy has recently emerged as a candidate to enable multiple therapeutic applications including protein replacement therapy, vaccine immunology, and regenerative medicine. Despite the extensive potential, successful clinical translation of therapies been very limited in practice due inadequate understanding how target various organs or cell type for expression. Multiple studies past decade have demonstrated carrier material properties routes administration significant parameters influencing expression profile therapeutics. However, disparate nature these reports prevented critical global factors contribute organ targeting delivery. Elucidation trends commonalities materials achieving tissue specific delivery may realization medical commercial promise medicines. The purpose this review is provide thorough robust meta-analysis that successfully used different article summarizes distinct well evaluates therapeutics can be achieved. This will therefore serve useful guide community development future full potential nucleic acid modality therapy.

Language: Английский

Citations

38
Principles for optimization and validation of mRNA lipid nanoparticle vaccines against COVID-19 using 3D bioprinting DOI
Massimiliano Papi, Daniela Pozzi, Valentina Palmieri

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 43, P. 101403 - 101403

Published: Jan. 20, 2022

Language: Английский

Citations

37
Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage DOI
Qilin Li,

Rengui Xu,

Huiling Fan

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7512 - 7524

Published: April 22, 2022

The key to controlling the spread of coronavirus disease 2019 (COVID-19) and reducing mortality is highly dependent on safe effective use vaccines for general population. Current COVID-19 vaccination practices (intramuscular injection solution-based vaccines) are limited by heavy reliance medical professionals, poor compliance, laborious recording procedures, resulting in a waste health resources low coverage, etc. In this study, we developed smart mushroom-inspired imprintable lightly detachable (MILD) microneedle platform convenient delivery multidose decentralized vaccine information storage. mushroom-like structure allows MILD system be easily pressed into skin detached from patch base, acting as "tattoo" record counts situ without any storage equipment, offering quick accessibility effortless readout, saving great deal valuable time energy both patients professionals. After loading inactivated SARS-CoV-2 virus-based vaccines, induced high level antibodies against receptor-binding domain (RBD) vivo eliciting systemic toxicity local damage. Collectively, serves promising carrier improve efficacy through its dual capabilities data storage, thus exhibiting potential helping contain pandemic or resurgence.

Language: Английский

Citations

36
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective DOI Open Access
Hagar I. Labouta, Róbert Langer, Pieter R. Cullis

et al.

Drug Delivery and Translational Research, Journal Year: 2022, Volume and Issue: 12(11), P. 2581 - 2588

Published: March 15, 2022

Language: Английский

Citations

34
Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models DOI Creative Commons
Patrícia Zoio, Abel Oliva

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(3), P. 682 - 682

Published: March 21, 2022

The increased demand for physiologically relevant in vitro human skin models testing pharmaceutical drugs has led to significant advancements engineering. One of the most promising approaches is use microfluidic systems generate advanced models, commonly known as skin-on-a-chip (SoC) devices. These devices allow simulation key mechanical, functional and structural features skin, better mimicking native microenvironment. Importantly, contrary conventional cell culture techniques, SoC can perfuse tissue, either by inclusion perfusable lumens or channels acting engineered vasculature. Moreover, integrating sensors on device allows real-time, non-destructive monitoring function effect topically systemically applied drugs. In this Review, major challenges prerequisites creation drug are considered. Technical (e.g., fabrication sensor integration) biological sourcing scaffold materials) aspects discussed. Recent here presented, their main achievements drawbacks compared Finally, review highlights current that need be overcome clinical translation

Language: Английский

Citations

31
Microneedle-Based Vaccine Delivery: Review of an Emerging Technology DOI Open Access
Ihab Mansoor, Heba A. Eassa,

Kamilia H. A. Mohammed

et al.

AAPS PharmSciTech, Journal Year: 2022, Volume and Issue: 23(4)

Published: April 5, 2022

Language: Английский

Citations

30
Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses DOI

Yanting Zheng,

Zhiming Li, Shaohua Li

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 203 - 214

Published: July 23, 2024

Language: Английский

Citations

8
Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic? DOI Creative Commons
Alberto Migliore, Gianfranco Gigliucci,

Raffaele Di Marzo

et al.

Risk Management and Healthcare Policy, Journal Year: 2021, Volume and Issue: Volume 14, P. 2079 - 2087

Published: May 1, 2021

Abstract: This narrative review is the final output of an initiative SIM (Italian Society Mesotherapy). A scientific literature on efficacy fractional intradermal vaccination in comparison with full doses has been conducted for following pathogens: influenza virus, rabies poliovirus (PV), hepatitis B virus (HBV), (HAV), diphtheria-tetanus-pertussis bacterias (DTP), human papillomavirus (HPV), Japanese encephalitis (JE), meningococcus, varicella zoster (VZV) and yellow fever virus. The findings suggest that use route represents a valid strategy terms efficiency influenza, HBV vaccines. Some systematic reviews vaccines absence substantial difference between immunogenicity induced by ID dose up to 20% IM healthy adults, elderly, immunocompromised patients children. Clinical studies remaining against other pathogens (HAV, DTP bacterias, JE, meningococcal disease, VZV, virus) are scarce, but promising. In context COVID-19 vaccine shortage, countries should investigate if dosing scheme may help save achieve herd immunity quickly. urges community health authorities potentiality fractionate administration anti-COVID-19 vaccination. Keywords: vaccination, intradermal, COVID-19, sparing

Language: Английский

Citations

41
Advanced Materials for SARS‐CoV‐2 Vaccines DOI
Moustafa T. Mabrouk,

Wei‐Chiao Huang,

Luis Martínez‐Sobrido

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(12)

Published: Dec. 11, 2021

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory 2 (SARS-CoV-2), has killed untold millions worldwide and hurtled vaccines into the spotlight as a go-to approach to mitigate it. Advances in virology, genomics, structural biology, vaccine technologies have enabled rapid unprecedented rollout of COVID-19 vaccines, although much developing world remains unvaccinated. Several new platforms been developed or deployed against SARS-CoV-2, with most targeting large viral Spike immunogen. Those that safely induce strong durable antibody responses at low dosages are advantageous, well those can be rapidly produced scale. Virtually all adjuvants possess nanoscale microscale dimensions represent diverse unique biomaterials. Viral vector platforms, lipid nanoparticle mRNA multimeric display for subunit received attention. Nanoscale also used combination other vaccines. To deal ready potential future ones, advanced will continue near future. Herein, recent use materials is summarized.

Language: Английский

Citations

37
3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery DOI Creative Commons
Merima Sirbubalo, Amina Tucak, Kenan Muhamedagić

et al.

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(7), P. 924 - 924

Published: June 22, 2021

Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices micron-sized dimensions that penetrate skin painlessly and thus facilitate transdermal administration a wide range active substances. MNs have been manufactured by variety production technologies, from materials, but most these manufacturing methods are time-consuming expensive for screening new designs making any modifications. Additive (AM) has become one revolutionary tools in pharmaceutical field, with its unique ability to manufacture personalized dosage forms patient-specific medical such as MNs. This review aims summarize various 3D printing technologies can produce digital models single step, including survey on their benefits drawbacks. In addition, this paper highlights current research field printed MN-assisted drug delivery systems analyzes parameters affecting mechanical properties The regulatory framework associated well different analysis evaluation MN outlined.

Language: Английский

Citations

36