A review of Ganoderma lucidum polysaccharides: Health benefit, structure–activity relationship, modification, and nanoparticle encapsulation

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 243, P. 125199 - 125199

Published: June 6, 2023

Language: Английский

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The major roles of intestinal microbiota and TRAF6/NF-κB signaling pathway in acute intestinal inflammation in mice, and the improvement effect by Hippophae rhamnoides polysaccharide

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139710 - 139710

Published: Jan. 9, 2025

Language: Английский

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Marine algal polysaccharides for drug delivery applications: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139551 - 139551

Published: Jan. 7, 2025

Language: Английский

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Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(31), P. 5853 - 5872

Published: Jan. 1, 2022

As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation.

Language: Английский

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Prebiotic potential of apple pomace and pectins from different apple varieties: Modulatory effects on key target commensal microbial populations

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 133, P. 107958 - 107958

Published: July 9, 2022

Pectin is a group of structurally diverse dietary fibers, very abundant in agri-food waste and by-products such as those generated during apple cider manufacturing. In recent years, pectin pectinoligosaccharides have demonstrated good fermentation properties prominent health promoting traits, particularly ameliorating certain inflammatory conditions. previous investigations pomace derived from production monovarietal Asturian ciders was to represent source with varied structural characteristics. this work we investigated vitro the modulatory effect fractions selected on human microbiota healthy subjects bowel disease (IBD) patients through fecal batch fermentations 16S rRNA gene sequencing. Overall, these promoted growth Akkermansia, Lachnospiraceae UCG-010, Prevotella, Sucinivibrio Turicibacter samples donors, while Blautia, CAG-56, Dialister, Eubacterium eligens Intestinimonas were stimulated IBD patients. The E. group, Succinivibrio only occurred tested by-products, not other non-pectic prebiotics/substrates. Galactose content (Arabinose + Galactose)/Rhamnose ratio pomace, galactose rhamnose pectin, positively associated promotion most genera. This comprehensively characterize gut modulation demonstrating capacity distinct fractions. diversifies opportunities achieve valorization formulation novel prebiotics for particular population groups.

Language: Английский

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Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Advanced Science, Journal Year: 2023, Volume and Issue: 10(31)

Published: Sept. 22, 2023

Modulating the inflammatory microenvironment can inhibit process of diseases (IDs). A tri-cross-linked microenvironment-responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery regulates microenvironment. Here, this study develops an (OD-PP@SeNPs) composed phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), selenium nanoparticles (SeNPs). The introduction SeNPs as initiators nano-fillers into results in extra cross-linking polymer network through hydrogen bonding. Based on Schiff base bonds, Phenylboronate ester a reactive oxygen species (ROS)/pH dual responsive triple-network is achieved. has injectable, self-healing, adhesion, outstanding flexibility, suitable swelling capacity, optimal biodegradability, excellent stimuli-responsive active substance release performance, prominent biocompatibility. Most importantly, ROS scavenging pH-regulating ability protects cells from oxidative stress induces macrophages M2 polarization to reduce cytokines PI3K/AKT/NF-κB MAPK pathways, exerting anti-inflammatory effects reshaping microenvironment, thereby effectively treating typical IDs, including S. aureus infected wound rheumatoid arthritis rats. In conclusion, dynamically injectable structure provides effective strategy treat holding great promise clinical application.

Language: Английский

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Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 18, 2023

Due to oral nano-delivery systems for the treatment of inflammatory bowel disease (IBD) are often failed accumulated colonic site and could not achieve controlled drug release, it's urgent develop a microenvironment responsive delivery improve therapy efficacy. Inflammation at IBD is mainly mediated by macrophages, which key effector cells. Excessive inflammation leads oxidative stress intestinal mucosal damage. The use curcumin (CUR) emodin (EMO) together promising due their respective anti-inflammatory repair effects. In view pH gradient environment gastrointestinal tract, here we prepared pH-responsive sodium alginate (SA) hydrogel-coated nanoemulsions co-deliver CUR EMO (CUR/EMO NE@SA) release specifically target macrophages colon.In this study, CUR/EMO NE@SA was successfully developed, in NE loaded chitosan further crosslinked with alginate. had property colon. preparation significantly alleviate colon decreasing TNF-α IL-6 expression, increasing IL-10 scavenging reactive oxygen species ameliorating restoration tight junction protein expression. Furthermore, revealed molecular mechanism treatment, might synergic inhibition NF-κB pro-inflammatory microenvironment. Our study provides new strategy via synergically inhibiting inflammatory, repairing clearing ROS pH-sensitive hydrogel-encapsulated nanoemulsion system, be developed other chronic treatment.It's suggested that nanoemulsion-based codelivery combinatorial platform IBD.

Language: Английский

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Oral delivery of porous starch-loaded bilayer microgels for controlled drug delivery and treatment of ulcerative colitis

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 314, P. 120887 - 120887

Published: April 11, 2023

Language: Английский

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Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(19)

Published: March 16, 2023

Abstract Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with variety of painful clinical manifestations an increased risk cancerization or death, has become emerging challenge to global healthcare due its rapidly increasing incidence. At present, there is no efficient cure against IBD because the elusive etiology pathogenesis IBD. Therefore, development alternative therapeutic strategies positive efficacy reduced side effects urgently needed. In recent years, great prosperity nanomedicine promoted by advanced nanomaterials redefining more attractive promising for owing their advantages in physiological stability, bioavailability, targeting sites. this review, firstly basic characteristics healthy intestinal microenvironments are presented. Then, different administration routes nanotherapeutics treatment reviewed. Subsequently, specific focus placed on introduction nanotherapeutic treatments based pathogenesis. Finally, some future challenges perspectives currently developed nanomedicines provided. It believed that above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry pharmaceutics.

Language: Английский

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Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 316, P. 121025 - 121025

Published: May 23, 2023

Language: Английский

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