An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo DOI Creative Commons
Huimin Kong, Chunxiong Zheng, Ke Yi

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 20, 2024

Abstract The membrane-fusion-based internalization without lysosomal entrapment is advantageous for intracellular delivery over endocytosis. However, protein corona formed on the membrane-fusogenic liposome surface converts its membrane-fusion performance to lysosome-dependent endocytosis, causing poorer efficiency in biological conditions. Herein, we develop an antifouling effective vivo. Leveraging specific lipid composition at optimized ratio, such facilitates fusion capacity even protein-rich conditions, attributed copious zwitterionic phosphorylcholine groups protein-adsorption resistance. Consequently, demonstrates robust membrane-fusion-mediated medium with up 38% fetal bovine serum, outclassing two traditional liposomes 4% and 6% concentrations. When injected into mice, can keep their membrane-fusion-transportation behaviors, thereby achieving efficient luciferase transfection enhancing gene-editing-mediated viral inhibition. This study provides a promising tool under complex physiological environments, enlightening future nanomedicine design.

Language: Английский

Multifunctional nanoparticle-mediated combining therapy for human diseases DOI Creative Commons
Xiaotong Li,

Xiuju Peng,

Makhloufi Zoulikha

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

Citations

125
Stealth and pseudo-stealth nanocarriers DOI Creative Commons

Panyue Wen,

Wendong Ke,

Anjaneyulu Dirisala

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 198, P. 114895 - 114895

Published: May 19, 2023

Language: Английский

Citations

111
Current research trends of nanomedicines DOI Creative Commons
Qiuyue Liu, Jiahui Zou, Zhongjian Chen

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4391 - 4416

Published: May 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Language: Английский

Citations

82
Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials DOI Creative Commons
Manman Xu, Xinpu Han, Hongtai Xiong

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5145 - 5145

Published: June 30, 2023

Cancer continues to pose a severe threat global health, making pursuing effective treatments more critical than ever. Traditional therapies, although pivotal in managing cancer, encounter considerable challenges, including drug resistance, poor solubility, and difficulties targeting tumors, specifically limiting their overall efficacy. Nanomedicine's application cancer therapy signals new epoch, distinguished by the improvement of specificity, efficacy, tolerability treatments. This review explores mechanisms advantages nanoparticle-mediated delivery, highlighting passive active strategies. Furthermore, it transformative potential nanomedicine tumor therapeutics, delving into its applications across various treatment modalities, surgery, chemotherapy, immunotherapy, radiotherapy, photodynamic photothermal therapy, gene as well diagnosis imaging. Meanwhile, outlook therapeutics is discussed, emphasizing need for addressing toxicity concerns, improving delivery strategies, enhancing carrier stability controlled release, simplifying nano-design, exploring novel manufacturing technologies. Overall, integrating holds immense revolutionizing patient outcomes.

Language: Английский

Citations

80
Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona DOI
Huan Tang, Ying Zhang, Tong Yang

et al.

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(9), P. 1067 - 1077

Published: Aug. 3, 2023

Language: Английский

Citations

78
Cancer signaling, cell/gene therapy, diagnosis and role of nanobiomaterials DOI Open Access
Gvozden Rosić

Advances in Biology & Earth Sciences, Journal Year: 2024, Volume and Issue: 9(Special Issue), P. 11 - 34

Published: April 11, 2024

An important characteristic of cancer is aberrant metabolism. Drug resistance, stem cells, metastasis and tumorigenesis are all significantly impacted by abnormal metabolism, which includes enhanced anabolic pathways aerobic glycolysis. The Hippo pathway, Myc PI3K/AKT recognized oncogenic signaling networks that control the expression metabolic genes increase level activity enzymes. On other hand, result in disruptions to internal signal transduction providing energy, building blocks redox capabilities necessary for uncontrolled cell proliferation. Studies clinical trials being carried out investigate impact minute substances or dietary modifications, such as calorie restriction, fasting intermittent fasting, on inhibition phenotypes malignancies remarkably diverse, much like genetic variability. Genetic abnormalities a variety signals found tumor microenvironment contribute this Therefore, one main objectives contemporary therapies overcome plasticity. This overview explains relationships between biochemical emphasizes recent research properties cancer. We also present fresh justifications upcoming class medications target an our latest studies progress nanomedicine disease detection at tiny nano-bio interactions biological systems nanoparticles. Significant field has been accomplished last 20 years. However, absence thorough knowledge situation makes it difficult improve overall patient survival with nanomedicine.

Language: Английский

Citations

73
Emerging ultrasmall luminescent nanoprobes for in vivo bioimaging DOI Creative Commons
Shihua Li, Jing Wei, Qiaofeng Yao

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(5), P. 1672 - 1696

Published: Jan. 1, 2023

Ultrasmall luminescent nanoprobes have shown some unique imaging advantages and application scenarios. In this review, we present a comprehensive summary discussion of ultrasmall towards in vivo PL bioimaging.

Language: Английский

Citations

64
Approved Nanomedicine against Diseases DOI Creative Commons

Yuanchao Jia,

Yuxin Jiang,

Yonglong He

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 774 - 774

Published: Feb. 26, 2023

Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one the most effective approaches in elevating drug‘s treatment efficacy reducing toxicity by improving drug solubility, altering biodistribution, controlling release. The development materials has brought profound revolution medicine, significantly affecting various major diseases such as cancer, injection, cardiovascular experienced explosive growth past few years. Although clinical transition nanomedicine not very satisfactory, traditional drugs still occupy dominant position formulation development, but increasingly active have adopted nanoscale forms limit side effects improve efficacy. review summarized approved nanomedicine, its indications, properties commonly used nanocarriers nanotechnology.

Language: Английский

Citations

59
Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent DOI Creative Commons

Revadee Liam‐Or,

Farid N. Faruqu,

Adam A. Walters

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(6), P. 846 - 855

Published: Feb. 16, 2024

Abstract Extracellular vesicles (EVs) derived from mesenchymal stem cells are promising nanotherapeutics in liver diseases due to their regenerative and immunomodulatory properties. Nevertheless, a concern has been raised regarding the rapid clearance of exogenous EVs by phagocytic cells. Here we explore impact protein corona on two culturing conditions which specific proteins acquired media were simultaneously adsorbed EV surface. Additionally, incubating with serum, simulating formation upon systemic delivery, further resolved corona–EV complex patterns investigated. Our findings reveal potential influences composition under vitro vivo kinetics. data suggest that bound albumin creates an signature can retarget hepatic macrophages. This results markedly improved cellular uptake hepatocytes, sinusoidal endothelial stellate phenomenon be applied as camouflage strategy precoating fabricate albumin-enriched complex, enhancing non-phagocytic liver. work addresses critical challenge facing intravenously administered for therapy tailoring cell targeting immune evasion.

Language: Английский

Citations

57
Mechanistic Understanding of Protein Corona Formation around Nanoparticles: Old Puzzles and New Insights DOI Creative Commons
Karin Nienhaus, G. Ulrich Nienhaus

Small, Journal Year: 2023, Volume and Issue: 19(28)

Published: April 3, 2023

Abstract Although a wide variety of nanoparticles (NPs) have been engineered for use as disease markers or drug delivery agents, the number nanomedicines in clinical has hitherto remained small. A key obstacle nanomedicine development is lack deep mechanistic understanding NP interactions bio‐environment. Here, focus on biomolecular adsorption layer (protein corona), which quickly enshrouds pristine exposed to biofluid and modifies way interacts with After brief introduction NPs nanomedicine, proteins, their mutual interactions, research aimed at addressing fundamental properties protein corona, specifically its mono‐/multilayer structure, reversibility irreversibility, time dependence, well role agglomeration, critically reviewed. It becomes quite evident that knowledge corona still fragmented, conflicting results issues call further studies. The article concludes discussion future directions should be taken advance around NPs. This will provide developers predictive power account these design efficacious nanomedicines.

Language: Английский

Citations

43