Stealth and pseudo-stealth nanocarriers

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 198, P. 114895 - 114895

Published: May 19, 2023

Language: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

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Targeting endothelial permeability in the EPR effect

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 212 - 235

Published: Aug. 8, 2023

Language: Английский

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Recent advances of plant-mediated metal nanoparticles: Synthesis, properties, and emerging applications for wastewater treatment

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112345 - 112345

Published: Feb. 28, 2024

Language: Английский

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mRNA nanodelivery systems: targeting strategies and administration routes

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for prevention and treatment various refractory diseases. To function efficiently in vivo overcome clinical limitations, demands safe stable vectors a reasonable administration route, bypassing multiple biological barriers achieving organ-specific targeted delivery mRNA. Nanoparticle (NP)-based systems representing leading vector approaches ensure successful intracellular to target organ. In this review, chemical modifications types advanced NPs, including lipid NPs polymers are summarized. The importance passive targeting, especially endogenous active targeting nano-delivery is emphasized, different cellular endocytic mechanisms discussed. Most importantly, based on above content physiological structure characteristics organs vivo, design strategies cells classified Furthermore, influence routes highlighted. Finally, an outlook remaining challenges future development toward therapies precision medicine provided.

Language: Английский

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Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Jan. 28, 2024

Abstract Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or solid tumors has entered the era precision medicine that requires systematic knowledge nano‐biological interactions from multidisciplinary perspectives. To this end, review first provides an overview membrane‐disruption methods such as electroporation, sonoporation, photoporation, microfluidic delivery, and microinjection with merits high‐throughput enhanced efficiency for in vitro NDC delivery. The impact characteristics including particle size, shape, charge, hydrophobicity, elasticity on cellular uptake are elaborated several types systems aiming hierarchical targeting vivo reviewed. Emerging ex human/animal‐derived pathophysiological models further explored highly recommended use studies since they might mimic features fill translational gaps animals humans. exploration modern microscopy techniques precise nanoparticle (NP) tracking at cellular, organ, organismal levels informs tailored development NDCs application clinical translation. Overall, integrates latest insights into smart nanosystem engineering, physiological models, imaging‐based validation tools, all directed towards enhancing efficient intracellular NDCs.

Language: Английский

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Lipid Nanoparticle-Based Delivery System─A Competing Place for mRNA Vaccines

ACS Omega, Journal Year: 2024, Volume and Issue: 9(6), P. 6219 - 6234

Published: Jan. 30, 2024

mRNA, as one of the foci biomedical research in past decade, has become a candidate vaccine solution for various infectious diseases and tumors regenerative medicine immunotherapy due to its high efficiency, safety, effectiveness. A stable effective delivery system is needed protect mRNAs from nuclease degradation while also enhancing immunogenicity. The success mRNA lipid nanoparticles treating COVID-19, certain extent, marks milestone vaccines promotes further on systems. Here, we explore systems, especially (LNPs), considering current status, prospects, challenges nanoparticles, other

Language: Английский

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PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 282 - 296

Published: Jan. 4, 2024

Language: Английский

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Zinc oxide nanoparticles promote migrasomes formation

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137792 - 137792

Published: Feb. 28, 2025

Language: Английский

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Oxygen/sulfate radicals-generating CaS2O8 nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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